Human dynein–dynactin is a fast processive motor in living cells [PDF]
eLifeMinus-end directed transport along microtubules in eukaryotes is primarily mediated by cytoplasmic dynein and its cofactor dynactin. Significant advances have been made in recent years characterizing human dynein–dynactin structure and function using in ...
Vikash Verma +2 more
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NuMA and Ninein: Dynein Cargo-Adaptors Without a Classical Cargo [PDF]
CellsDynein is a minus-end-directed microtubule motor that transports a variety of cargoes. Cargo specificity is mediated by a class of adaptor proteins that bind to the interface between dynein and dynactin, along the length of the Arp1 filament of dynactin,
Keying Guo, Andreas Merdes
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Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1 [PDF]
Frontiers in Molecular BiosciencesCytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
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Perry Disease: Concept of a New Disease and Clinical Diagnostic Criteria [PDF]
Journal of Movement Disorders, 2021 Perry disease is a hereditary neurodegenerative disease with autosomal dominant inheritance. It is characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (
Yoshio Tsuboi +2 more
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Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. [PDF]
PLoS ONE, 2017 Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein-dynactin-Bicaudal D2 is essential for highly processive movement.
Takuya Kobayashi +3 more
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Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein
Nature Communications, 2023 Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the ...
Kyoko Okada +6 more
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Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid. [PDF]
PLoS ONE, 2011 The mitotic checkpoint functions to ensure accurate chromosome segregation by regulating the progression from metaphase to anaphase. Once the checkpoint has been satisfied, it is inactivated in order to allow the cell to proceed into anaphase and ...
Jakub K Famulski +3 more
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dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. [PDF]
PLoS ONE, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly ...
Kensuke Ikenaka +11 more
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TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. [PDF]
PLoS ONE, 2012 The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent on microtubules. p150(Glued), a subunit of dynactin, has been implicated in the transport
Min Zong +7 more
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Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. [PDF]
PLoS ONE, 2008 BACKGROUND:Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained.
Jacob Shun-Jen Yang +2 more
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