Engineered kinesin motor proteins amenable to small-molecule inhibition [PDF]
Nature Communications, 2016 The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable ...
Martin F. Engelke +10 more
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Simulated actin reorganization mediated by motor proteins. [PDF]
PLoS Computational Biology, 2022 Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization in many different contexts, including during directed cell migration and over ...
Maria-Veronica Ciocanel +5 more
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Flagellar brake protein YcgR interacts with motor proteins MotA and FliG to regulate the flagellar rotation speed and direction [PDF]
Frontiers in Microbiology, 2023 In E. coli and related species, flagellar brake protein YcgR responds to the elevated intracellular c-di-GMP, decreases the flagellar rotation speed, causes a CCW rotation bias, and regulates bacterial swimming. Boehm et al.
Qun Han +11 more
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Non-transport functions of motor proteins in corticogenesis [PDF]
Frontiers in Cell and Developmental BiologyCerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina +5 more
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Navigation Strategies of Motor Proteins on Decorated Tracks. [PDF]
PLoS ONE, 2015 Motor proteins display widely different stepping patterns as they move on microtubule tracks, from the deterministic linear or helical motion performed by the protein kinesin to the uncoordinated random steps made by dynein.
Zsolt Bertalan +3 more
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Japan-US symposium on cytoskeletal motor proteins and their associated proteins [PDF]
Biophysics and Physicobiology, 2021 Kumiko Hayashi, Shinsuke Niwa
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Critical assessment of coiled-coil predictions based on protein structure data
Scientific Reports, 2021 Coiled-coil regions were among the first protein motifs described structurally and theoretically. The simplicity of the motif promises that coiled-coil regions can be detected with reasonable accuracy and precision in any protein sequence.
Dominic Simm +3 more
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What is axoplasmic transport? Considering the role of exercise training: A mini review [PDF]
Journal of Exercise & Organ Cross Talk, 2022 Like other cells in the body, nerve cells need many proteins and substances to maintain homeostasis. As we know, the transcription and translation of proteins and necessary cellular substances occurs in the cell nucleus.
Hasti Sherizadeh
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Molecular Motors–Nature’s Efficiency at Work
Reports in Advances of Physical Sciences, 2022 Nature has generated sophisticated and very efficient molecular motors, employed for nanoscale transport at the intracellular level. As a complementary tool to nanofluidics, these motors have been envisioned for nanotechnological devices.
Winfried Teizer
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Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
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