Results 1 to 10 of about 8,367,716 (316)
Cold Spring Harb Perspect Biol, 2018 Myosin motors power movements on actin filaments, whereas dynein and kinesin motors power movements on microtubules. The mechanisms of these motor proteins differ, but, in all cases, ATP hydrolysis and subsequent release of the hydrolysis products drives a cycle of interactions with the track (either an actin filament or a microtubule), resulting in ...
Sweeney HL, Holzbaur ELF.
europepmc +5 more sources
Subangstrom single-molecule measurements of motor proteins using a nanopore. [PDF]
Nat Biotechnol, 2015 Techniques for measuring the motion of single motor proteins, such as FRET and optical tweezers, are limited to a resolution of ∼300 pm. We use ion current modulation through the protein nanopore MspA to observe translocation of helicase Hel308 on DNA ...
Derrington IM +12 more
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Engineered kinesin motor proteins amenable to small-molecule inhibition [PDF]
Nature Communications, 2016 The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable ...
Martin F. Engelke +10 more
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Role of motor proteins in human cancers. [PDF]
Saudi J Biol Sci, 2022 Motor proteins include several protein families (Kinesin, Dynein and Myosin) responsible for intracellular transport, intercellular communication, among other functions.
Hassan Ibrahim I +3 more
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Motor proteins at the mitochondria-cytoskeleton interface.
J Cell Sci, 2021 Mitochondria are multifunctional organelles that not only produce energy for the cell, but are also important for cell signalling, apoptosis and many biosynthetic pathways.
Kruppa AJ, Buss F.
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Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins. [PDF]
Proc Natl Acad Sci U S A, 2019 Two mechanisms have been proposed for the function of motor proteins: The power stroke and the Brownian ratchet. The former refers to generation of a large downhill free energy gradient over which the motor protein moves nearly irreversibly in making a ...
Hwang W, Karplus M.
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Simulated actin reorganization mediated by motor proteins. [PDF]
PLoS Computational Biology, 2022 Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization in many different contexts, including during directed cell migration and over ...
Maria-Veronica Ciocanel +5 more
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Flagellar brake protein YcgR interacts with motor proteins MotA and FliG to regulate the flagellar rotation speed and direction [PDF]
Frontiers in Microbiology, 2023 In E. coli and related species, flagellar brake protein YcgR responds to the elevated intracellular c-di-GMP, decreases the flagellar rotation speed, causes a CCW rotation bias, and regulates bacterial swimming. Boehm et al.
Qun Han +11 more
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A Unified Walking Model for Dimeric Motor Proteins. [PDF]
Biophys J, 2018 Dimeric motor proteins, kinesin-1, cytoplasmic dynein-1, and myosin-V, move stepwise along microtubules and actin filaments with a regular step size. The motors take backward as well as forward steps.
Sasaki K, Kaya M, Higuchi H.
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Connecting two arrays: The emerging role of actin-microtubule cross-linking motor proteins
Frontiers in Plant Science, 2015 The cytoskeleton of plant cells, consisting of actin filaments (AFs) and microtubules (MTs), is a central structure for various intracellular processes, such as cell division, isotropic and polar growth, vesicle transport, cell shape and morphogenesis ...
René eSchneider, Staffan ePersson
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