Non-transport functions of motor proteins in corticogenesis [PDF]
Frontiers in Cell and Developmental BiologyCerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina +5 more
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Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment [PDF]
Cell Communication and SignalingBackground Class I myosins are essential mediators of membrane–cytoskeleton interactions that support key cellular processes such as endocytosis, secretion, intracellular trafficking, and mitosis.
Girish Rajendraprasad +8 more
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Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells [PDF]
Nature CommunicationsStereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration.
Takushi Miyoshi +9 more
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The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression [PDF]
The Journal of Clinical InvestigationLoss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes
Jayashree Thatte +17 more
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Class I Myosins, molecular motors involved in cell migration and cancer
Cell Adhesion & Migration, 2022 Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins.
Juan D. Diaz-Valencia +4 more
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Functional Role of Class III Myosins in Hair Cells
Frontiers in Cell and Developmental Biology, 2021 Cytoskeletal motors produce force and motion using the energy from ATP hydrolysis and function in a variety of mechanical roles in cells including muscle contraction, cargo transport, and cell division.
Joseph A. Cirilo +2 more
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Non-muscle myosins control the integrity of cortical radial glial endfeet
PLoS Biology, 2023 Radial glial cells, the stem cells of the cerebral cortex, extend a long basal fiber that ends in basal endfeet. A new study in PLOS Biology found that non-muscle myosins control basal endfoot integrity to regulate interneuron organization.
Li Wang, Arnold R. Kriegstein
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Myosin V and iNOS expression is enhanced in J774 murine macrophages treated with IFN-gamma [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Actin-based motor protein requirements and nitric oxide (NO) production are important features of macrophage activity during phagocytosis or microbicidal processes.
D.S. Reis +3 more
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The loop2 insertion of type IX myosin acts as an electrostatic actin tether that permits processive movement. [PDF]
PLoS ONE, 2014 Although class IX myosins are single-headed, they demonstrate characteristics of processive movement along actin filaments. Double-headed myosins that move processively along actin filaments achieve this by successive binding of the two heads in a hand ...
Kerstin Elfrink +4 more
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Myosin 1g and 1f: A Prospective Analysis in NK Cell Functions
Frontiers in Immunology, 2021 NK cells are contained in the ILC1 group; they are recognized for their antiviral and antitumor cytotoxic capacity; NK cells also participate in other immune response processes through cytokines secretion.
David Cruz-Zárate +6 more
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