Myosins VIII and XI Play Distinct Roles in Reproduction and Transport of Tobacco Mosaic Virus
PLoS Pathogens, 2014 Viruses are obligatory parasites that depend on host cellular factors for their replication as well as for their local and systemic movement to establish infection.
Khalid Amari +2 more
exaly +3 more sources
Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins [PDF]
PLoS ONE, 2013 Despite their near sequence identity, actin isoforms cannot completely replace each other in vivo and show marked differences in their tissue-specific and subcellular localization.
Manuel H Taft +2 more
exaly +2 more sources
Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment [PDF]
Cell Communication and SignalingBackground Class I myosins are essential mediators of membrane–cytoskeleton interactions that support key cellular processes such as endocytosis, secretion, intracellular trafficking, and mitosis.
Girish Rajendraprasad +8 more
doaj +2 more sources
Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells [PDF]
Nature CommunicationsStereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration.
Takushi Miyoshi +9 more
doaj +2 more sources
Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins?
Frontiers in PhysiologyInitially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Peter J Hanley
exaly +3 more sources
The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression [PDF]
The Journal of Clinical InvestigationLoss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes
Jayashree Thatte +17 more
doaj +2 more sources
Gliding motility of the diatom Craspedostauros australis coincides with the intracellular movement of raphid-specific myosins [PDF]
Communications BiologyRaphid diatoms are one of the few eukaryotes capable of gliding motility, which is remarkably fast and allows for quasi-instantaneous directional reversals.
Metin G. Davutoglu +9 more
doaj +2 more sources
Class I Myosins, molecular motors involved in cell migration and cancer
Cell Adhesion & Migration, 2022 Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins.
Juan D. Diaz-Valencia +4 more
doaj +1 more source
Functional Role of Class III Myosins in Hair Cells
Frontiers in Cell and Developmental Biology, 2021 Cytoskeletal motors produce force and motion using the energy from ATP hydrolysis and function in a variety of mechanical roles in cells including muscle contraction, cargo transport, and cell division.
Joseph A. Cirilo +2 more
doaj +1 more source
Myosin V and iNOS expression is enhanced in J774 murine macrophages treated with IFN-gamma [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Actin-based motor protein requirements and nitric oxide (NO) production are important features of macrophage activity during phagocytosis or microbicidal processes.
D.S. Reis +3 more
doaj +1 more source