Myosins VIII and XI Play Distinct Roles in Reproduction and Transport of Tobacco Mosaic Virus
PLoS Pathogens, 2014 Viruses are obligatory parasites that depend on host cellular factors for their replication as well as for their local and systemic movement to establish infection.
Khalid Amari +2 more
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Unraveling the fastest myosin: Discovery history and structure-function relationships of algae Chara myosin XI [PDF]
Biophysics and PhysicobiologyPlant myosins have higher velocities than animal myosins. Among them, myosins in freshwater algae of the genus Chara have extremely high velocities. We have biochemically studied myosins that perform high-speed movements in the alga Chara.
Kohji Ito, Takeshi Haraguchi
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Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins [PDF]
PLoS ONE, 2013 Despite their near sequence identity, actin isoforms cannot completely replace each other in vivo and show marked differences in their tissue-specific and subcellular localization.
Peter Claus +2 more
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Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells [PDF]
Nature CommunicationsStereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration.
Takushi Miyoshi +9 more
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Long-tailed class I myosins rely on tail-mediated phosphoinositide recognition for specific membrane recruitment [PDF]
Cell Communication and SignalingBackground Class I myosins are essential mediators of membrane–cytoskeleton interactions that support key cellular processes such as endocytosis, secretion, intracellular trafficking, and mitosis.
Girish Rajendraprasad +8 more
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Switch-2 determines Mg2+ADP-release kinetics and fine-tunes the duty ratio of Dictyostelium class-1 myosins [PDF]
Frontiers in PhysiologyThough myosins share a structurally conserved motor domain, single amino acid variations of active site elements, including the P-loop, switch-1 and switch-2, which act as nucleotide sensors, can substantially determine the kinetic signature of a myosin,
Ralph P. Diensthuber +4 more
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The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression [PDF]
The Journal of Clinical InvestigationLoss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes
Jayashree Thatte +17 more
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Gliding motility of the diatom Craspedostauros australis coincides with the intracellular movement of raphid-specific myosins [PDF]
Communications BiologyRaphid diatoms are one of the few eukaryotes capable of gliding motility, which is remarkably fast and allows for quasi-instantaneous directional reversals.
Metin G. Davutoglu +9 more
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Class I Myosins, molecular motors involved in cell migration and cancer
Cell Adhesion & Migration, 2022 Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins.
Juan D. Diaz-Valencia +4 more
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Functional Role of Class III Myosins in Hair Cells
Frontiers in Cell and Developmental Biology, 2021 Cytoskeletal motors produce force and motion using the energy from ATP hydrolysis and function in a variety of mechanical roles in cells including muscle contraction, cargo transport, and cell division.
Joseph A. Cirilo +2 more
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