Results 1 to 10 of about 7,078 (114)
Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
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Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function
Cells, 2021 Unconventional myosins, linked to deafness, are also proposed to play a role in retinal cell physiology. However, their direct role in photoreceptor function remains unclear.
Ashish K. Solanki +11 more
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KLC4 shapes axon arbors during development and mediates adult behavior
eLife, 2022 Development of elaborate and polarized neuronal morphology requires precisely regulated transport of cellular cargos by motor proteins such as kinesin-1. Kinesin-1 has numerous cellular cargos which must be delivered to unique neuronal compartments.
Elizabeth M Haynes +7 more
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Cold Spring Harbor Perspectives in Biology, 2018 Myosin motors power movements on actin filaments, whereas dynein and kinesin motors power movements on microtubules. The mechanisms of these motor proteins differ, but, in all cases, ATP hydrolysis and subsequent release of the hydrolysis products drives a cycle of interactions with the track (either an actin filament or a microtubule), resulting in ...
H Lee, Sweeney, Erika L F, Holzbaur
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Biology Open, 2021 One of the main functions of physiological color change is thermoregulation. This change occurs much more rapidly than morphological color change, but the underlying mechanism remains poorly understood.
Kun Guo +5 more
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Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues
Biomolecules, 2022 Unconventional myosins are a superfamily of actin-based motor proteins that perform a number of roles in fundamental cellular processes, including (but not limited to) intracellular trafficking, cell motility, endocytosis, exocytosis and cytokinesis.
Chloe A Johnson +2 more
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Myosin V executes steps of variable length via structurally constrained diffusion
eLife, 2020 The molecular motor myosin V transports cargo by stepping on actin filaments, executing a random diffusive search for actin binding sites at each step.
David Hathcock +3 more
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Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy
Journal of Biomechanical Science and Engineering, 2021 The high sensitivity of mammalian hearing is achieved by cochlear amplification. The basis of this amplification is the motility of outer hair cells (OHCs), which are sensory cells in the inner ear.
Michio MURAKOSHI, Hiroshi WADA
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A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
Royal Society Open Science, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
L. Trott +2 more
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eLife, 2020 Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament.
Tatyana Bodrug +17 more
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