Results 1 to 10 of about 392,762 (297)
Molecular motor proteins and amyotrophic lateral sclerosis. [PDF]
Int J Mol Sci, 2011 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration ...
Soo KY, Farg M, Atkin JD.
europepmc +4 more sources
Cytoskeletal Dynamics and Molecular Motor Dysfunction in Psychiatric Disorders: Insights from Schizophrenia and Autism Spectrum Disorder [PDF]
BiologyElucidating the pathophysiological mechanisms of mental disorders remains a critical challenge in psychiatric research. Recent studies have highlighted the potential involvement of cytoskeletal and molecular motor abnormalities in the development of ...
Kenyu Nakamura +5 more
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A metal switch for controlling the activity of molecular motor proteins. [PDF]
Nat Struct Mol Biol, 2011 Kinesins are molecular motors that require a divalent metal ion (for example, Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP and report on a serine-to-cysteine substitution in the switch 1 motif of ...
Cochran JC, Zhao YC, Wilcox DE, Kull FJ.
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A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation [PDF]
Kidney Research and Clinical Practice, 2023 Background Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help improve
Felix Poppelaars +5 more
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Molecular Motors–Nature’s Efficiency at Work
Reports in Advances of Physical Sciences, 2022 Nature has generated sophisticated and very efficient molecular motors, employed for nanoscale transport at the intracellular level. As a complementary tool to nanofluidics, these motors have been envisioned for nanotechnological devices.
Winfried Teizer
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Cell Reports, 2021 Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar +12 more
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Frontiers in Cell and Developmental Biology, 2021 Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
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Synthetic, Protein-Based Molecular Motors [PDF]
Biophysical Journal, 2009 We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J. +7 more
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Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer
Acta Pharmaceutica Sinica B, 2021 Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian +9 more
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Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
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