Results 1 to 10 of about 224,088 (260)
Molecular motor proteins and amyotrophic lateral sclerosis. [PDF]
Int J Mol Sci, 2011 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration ...
Soo KY, Farg M, Atkin JD.
europepmc +4 more sources
A metal switch for controlling the activity of molecular motor proteins. [PDF]
Nat Struct Mol Biol, 2011 Kinesins are molecular motors that require a divalent metal ion (for example, Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP and report on a serine-to-cysteine substitution in the switch 1 motif of ...
Cochran JC, Zhao YC, Wilcox DE, Kull FJ.
europepmc +5 more sources
Molecular switch-like regulation in motor proteins [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors that enhance or suppress their NTPase activity.
Sara Tafoya, Carlos Bustamante
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Motor proteins and molecular motors: how to operate machines at the nanoscale [PDF]
Journal of Physics Condensed Matter, 2013 Several classes of biological molecules that transform chemical energy into mechanical work are known as motor proteins or molecular motors. These nanometer-sized machines operate in noisy stochastic isothermal environments, strongly supporting fundamental cellular processes such as the transfer of genetic information, transport, organization and ...
Anatoly B Kolomeisky
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Cytoskeletal Dynamics and Molecular Motor Dysfunction in Psychiatric Disorders: Insights from Schizophrenia and Autism Spectrum Disorder [PDF]
BiologyElucidating the pathophysiological mechanisms of mental disorders remains a critical challenge in psychiatric research. Recent studies have highlighted the potential involvement of cytoskeletal and molecular motor abnormalities in the development of ...
Kenyu Nakamura +5 more
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Life without double-headed non-muscle myosin II motor proteins
Frontiers in Chemistry, 2014 Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has
Venkaiah eBetapudi
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Correlation Imaging Reveals Specific Crowding Dynamics of Kinesin Motor Proteins
Physical Review X, 2017 Molecular motor proteins fulfill the critical function of transporting organelles and other building blocks along the biopolymer network of the cell’s cytoskeleton, but crowding effects are believed to crucially affect this motor-driven transport due to ...
Daniël M. Miedema +6 more
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A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation [PDF]
Kidney Research and Clinical Practice, 2023 Background Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help improve
Felix Poppelaars +5 more
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Molecular Motors–Nature’s Efficiency at Work
Reports in Advances of Physical Sciences, 2022 Nature has generated sophisticated and very efficient molecular motors, employed for nanoscale transport at the intracellular level. As a complementary tool to nanofluidics, these motors have been envisioned for nanotechnological devices.
Winfried Teizer
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Cell Reports, 2021 Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar +12 more
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