Results 1 to 10 of about 5,860,920 (296)

Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation

open access: yesCell Reports, 2021
Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar   +12 more
doaj   +3 more sources

Non-transport functions of motor proteins in corticogenesis [PDF]

open access: yesFrontiers in Cell and Developmental Biology
Cerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina   +5 more
doaj   +2 more sources

A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation [PDF]

open access: yesKidney Research and Clinical Practice, 2023
Background Despite current matching efforts to identify optimal donor-recipient pairs for kidney transplantation, alloimmunity remains a major source of late transplant failure. Additional genetic parameters in donor-recipient matching could help improve
Felix Poppelaars   +5 more
doaj   +1 more source

Molecular Motors–Nature’s Efficiency at Work

open access: yesReports in Advances of Physical Sciences, 2022
Nature has generated sophisticated and very efficient molecular motors, employed for nanoscale transport at the intracellular level. As a complementary tool to nanofluidics, these motors have been envisioned for nanotechnological devices.
Winfried Teizer
doaj   +1 more source

Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior

open access: yesFrontiers in Cell and Developmental Biology, 2021
Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
doaj   +1 more source

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

open access: yesActa Pharmaceutica Sinica B, 2021
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian   +9 more
doaj   +1 more source

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

open access: yeseLife, 2022
Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef   +10 more
doaj   +1 more source

A role for myosin VI in the localization of axonal proteins. [PDF]

open access: yesPLoS Biology, 2011
In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites.
Tommy L Lewis, Tianyi Mao, Don B Arnold
doaj   +1 more source

Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics

open access: yesMarine Drugs, 2016
Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally located ...
Joseph A. White   +2 more
doaj   +1 more source

Life without double-headed non-muscle myosin II motor proteins

open access: yesFrontiers in Chemistry, 2014
Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has
Venkaiah eBetapudi
doaj   +1 more source

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