Results 41 to 50 of about 230,773 (293)

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death ...
Rita F Marques, Kent E Duncan
doaj   +1 more source

An autonomous molecular transport system using DNAs and motor proteins in molecular communication [PDF]

2007 2nd Bio-Inspired Models of Network, Information and Computing Systems, 2007
This paper describes a molecular transport system in molecular communication that uses the machinery in living cells. The molecular transport system requires: 1) loading of the specified cargo molecules at a loading site (at a sender); 2) transport of the loaded cargoes to an unloading site (to a receiver); and 3) unloading of the transported cargoes ...
S. Hiyama, Y. Moritani, T. Suda, T. Shima, K. Sutoh   +4 more
openaire   +1 more source

Electrostatically biased binding of kinesin to microtubules [PDF]

, 2011
The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Zheng Wenjun, Zheng, Wenjun, Grant, Barry J, McCammon, J. Andrew, Grant, Barry J., Cross, Robert A., Gary Huber, McCammon, J Andrew, Dlugosz, Maciej, Maria Alonso, Huber, Gary, McCammon J. Andrew, Maciej Dlugosz, Barry J. Grant, J Andrew McCammon, Robert A. Cross, Gheorghe, Dana M, Cross, R. A., M. Gheorghe Dana, Wenjun Zheng, Barry J Grant, Alonso, M. (Maria), Alonso Maria, Robert A Cross, J. Andrew McCammon, Dana M Gheorghe, Dana M. Gheorghe, Cross Robert A., Alonso, Maria, Grant Barry J., Huber Gary, Cross, Robert A, Gheorghe, Dana M., Dlugosz Maciej   +33 more
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Intrinsic structural disorder in cytoskeletal proteins. [PDF]

, 2013
Cytoskeleton, the internal scaffold of the cell, displays an exceptional combination of stability and dynamics. It is composed of three major filamentous networks, microfilaments (actin filaments), intermediate filaments (neurofilaments), and ...
Szabó, Beáta, Guharoy, Majnak, Martos, Sara Contreras, Tompa, Péter   +3 more
core   +1 more source

Golgi fragmentation in ALS motor neurons. New mechanisms targeting microtubules, tethers and transport vesicles.

Frontiers in Neuroscience, 2015
Pathological alterations of the Golgi apparatus, such as its fragmentation represent an early pre-clinical feature of many neurodegenerative diseases and have been widely studied in the motor neuron disease amyotrophic lateral sclerosis (ALS).
Georg eHaase, Catherine eRabouille
doaj   +1 more source

Molecular motors in nanobiotechnology: Protein and DNA based molecular motors: A review

Results in Chemistry
Molecular motor can be defined as the collection of a separate number of molecular features (that is, a supramolecular structure) which has been developed to carry out a function through the mechanical movements of its components, which occurs when it is appropriately stimulated externally. Therefore, molecular motors include a part with a motor, which
Yathrib Ajaj, Zaid H. Mahmoud, Ameer Najy Obeed, Moatasem Al-Salih, Batool Ali Ahmed, Ekhlas Abdallah Hassan, Marwa Sabbar Falih, Mahdiyeh Nosratabadi, Ehsan Kianfar   +8 more
openaire   +2 more sources

Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa

BMC Research Notes, 2009
Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne, Peters Nick T, Kropf Darryl L   +2 more
doaj   +1 more source

Gene profiling of identified neurons to dissect molecular mechanisms involved in spinal reflex assembly [PDF]

, 2010
The central question during my PhD studies was to understand the molecular mechanisms and genetic cascades controlling the sequential specification of distinct classes of dorsal root ganglia (DRG) sensory neurons, with a particular focus on genes ...
Friese, Andreas
core   +1 more source

Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution

Communications Biology
An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators.
Martin Kollmar, Tobias Welz, Aishwarya Ravi, Thomas Kaufmann, Noura Alzahofi, Klas Hatje, Asmahan Alghamdi, Jiyu Kim, Deborah A. Briggs, Annette Samol-Wolf, Olena Pylypenko, Alistair N. Hume, Pawel Burkhardt, Jan Faix, Eugen Kerkhoff   +14 more
doaj   +1 more source

Dynamics of molecular motors in reversible burnt-bridge models

Condensed Matter Physics, 2010
Dynamic properties of molecular motors whose motion is powered by interactions with specific lattice bonds are studied theoretically with the help of discrete-state stochastic "burnt-bridge" models.
M.N. Artyomov, A.Yu. Morozov, A.B. Kolomeisky   +2 more
doaj   +1 more source