Results 31 to 40 of about 224,088 (260)

Golgi fragmentation in ALS motor neurons. New mechanisms targeting microtubules, tethers and transport vesicles.

Frontiers in Neuroscience, 2015
Pathological alterations of the Golgi apparatus, such as its fragmentation represent an early pre-clinical feature of many neurodegenerative diseases and have been widely studied in the motor neuron disease amyotrophic lateral sclerosis (ALS).
Georg eHaase, Catherine eRabouille
doaj   +1 more source

Molecular motors in nanobiotechnology: Protein and DNA based molecular motors: A review

Results in Chemistry
Molecular motor can be defined as the collection of a separate number of molecular features (that is, a supramolecular structure) which has been developed to carry out a function through the mechanical movements of its components, which occurs when it is appropriately stimulated externally. Therefore, molecular motors include a part with a motor, which
Yathrib Ajaj, Zaid H. Mahmoud, Ameer Najy Obeed, Moatasem Al-Salih, Batool Ali Ahmed, Ekhlas Abdallah Hassan, Marwa Sabbar Falih, Mahdiyeh Nosratabadi, Ehsan Kianfar   +8 more
openaire   +2 more sources

Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa

BMC Research Notes, 2009
Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne, Peters Nick T, Kropf Darryl L   +2 more
doaj   +1 more source

Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution

Communications Biology
An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators.
Martin Kollmar, Tobias Welz, Aishwarya Ravi, Thomas Kaufmann, Noura Alzahofi, Klas Hatje, Asmahan Alghamdi, Jiyu Kim, Deborah A. Briggs, Annette Samol-Wolf, Olena Pylypenko, Alistair N. Hume, Pawel Burkhardt, Jan Faix, Eugen Kerkhoff   +14 more
doaj   +1 more source

Dynamics of molecular motors in reversible burnt-bridge models

Condensed Matter Physics, 2010
Dynamic properties of molecular motors whose motion is powered by interactions with specific lattice bonds are studied theoretically with the help of discrete-state stochastic "burnt-bridge" models.
M.N. Artyomov, A.Yu. Morozov, A.B. Kolomeisky   +2 more
doaj   +1 more source

Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae

Bio-Protocol, 2017
Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai   +2 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Salivary gland proteome analysis of developing adult female Haemaphysalis longicornis ticks: molecular motor and TCA cycle-related proteins play an important role throughout development

Parasites & Vectors, 2019
Background Ticks are notorious blood-feeding arthropods that can spread a variety of deadly diseases. The salivary gland is an important organ for ticks to feed on blood, and this organ begins to develop rapidly when ixodid ticks suck blood.
Shuguang Ren, Baowen Zhang, Xiaomin Xue, Xiaoshuang Wang, Huaqu Zhao, Xiaoli Zhang, Minjing Wang, Qi Xiao, Hui Wang, Jingze Liu   +9 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Surface Passivation for Molecular Motor Protein Assays [PDF]

Biophysical Journal, 2010
In kinesin motiliy assays, it has been shown that the surfaces with which kinesin interacts must be passivated in order to prevent kinesin from denaturing on them. The most popular surface blocker is the casein family of milk proteins. Casein is usually purified to various degrees from bovine milk and has many unknowns associated with it when ...
Maloney, Andy, Black, Brigette D., Herskowitz, Lawrence J., Salvagno, Anthony L., Le, Linh N., Josey, Brian P., Koch, Steven J.   +6 more
openaire   +1 more source