Results 51 to 60 of about 224,088 (260)

Modeling a Microtubule Filaments Mesh Structure from Confocal Microscopy Imaging

Micromachines, 2020
This study introduces a modeling method for a supermolecular structure of microtubules for the development of a force generation material using motor proteins.
Yutaka Ueno, Kento Matsuda, Kaoru Katoh, Akinori Kuzuya, Akira Kakugo, Akihiko Konagaya   +5 more
doaj   +1 more source

Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment

Frontiers in Human Neuroscience, 2022
By age 85, most adults manifest some degree of motor impairment. However, in most individuals a specific etiology for motor decline and treatment to modify its inexorable progression cannot be identified.
Aron S. Buchman, Aron S. Buchman, David A. Bennett, David A. Bennett   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural and molecular changes in the epicenter of injury and distant segments of the rat spinal cord in response to rehabilitative motor training

Acta Biomedica Scientifica
Background. Spinal cord injury (SCI) leads to partial or complete loss of sensory and/or  motor functions below the injury site due to neuron and glial cell death, axonal degeneration, and disruption of the blood-spinal cord barrier (BSCB).
D. Kh. Sabirov, T. V. Ageeva, A. V. Timofeeva, E. A. Plotnikova, S. S. Arkhipova, E. F. Davletshin, Ya. O. Mukhamedshina   +6 more
doaj   +1 more source

Molecular Highways—Navigating Collisions of DNA Motor Proteins

Journal of Molecular Biology, 2018
Fundamental biological processes require concurrent sharing of DNA by numerous motor proteins and complexes. Thus, collision, congestion, and roadblocks are inescapable on these busy "molecular highways." The consequences of these traffic problems are diverse, resulting in complex cellular mechanisms to resolve threats to genome stability and ensure ...
Tung T, Le, Michelle D, Wang
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Proteomic analysis illustrates the potential involvement of motor proteins in cleft palate development

Scientific Reports
Cleft palate (CP) is a congenital condition characterized by a complex etiology and limited diagnostic and therapeutic options. In this study, we delved into the molecular mechanisms associated with retinoic acid (RA)-induced CP in Kun Ming mice ...
Zijian Huang, Chuzhao Zhang, Meng Sun, Aiwei Ma, Liyun Chen, Wenshi Jiang, Mengjing Xu, Xujue Bai, Jianda Zhou, Wancong Zhang, Shijie Tang   +10 more
doaj   +1 more source

Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Neurobiology of Disease, 2011
Expression of mutant SOD1 typical of familial amyotrophic lateral sclerosis (ALS) induces the expression of Bcl2-A1, a member of the Bcl2 family of proteins, specifically in motor neurons of transgenic mice.In this work, we have used immortalized motor ...
Ciro Iaccarino, Maria Elena Mura, Sonia Esposito, Franco Carta, Giovanna Sanna, Franco Turrini, Maria Teresa Carrì, Claudia Crosio   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source