Results 51 to 60 of about 5,860,920 (296)

Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry

Bioscience Reports, 2014
While the long-term physiological adaptation of the neuromuscular system to changed functional demands is usually reflected by unilateral skeletal muscle transitions, the progressive degeneration of distinct motor neuron populations is often associated ...
Ashling Holland, Thomas Schmitt‑John, Paul Dowling, Paula Meleady, Michael Henry, Martin Clynes, Kay Ohlendieck   +6 more
doaj   +1 more source

The Central Role of the F-Actin Surface in Myosin Force Generation

Biology, 2021
Actin is one of the most abundant and versatile proteins in eukaryotic cells. As discussed in many contributions to this Special Issue, its transition from a monomeric G-actin to a filamentous F-actin form plays a critical role in a variety of cellular ...
Matthew H. Doran, William Lehman
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular Highways—Navigating Collisions of DNA Motor Proteins

Journal of Molecular Biology, 2018
Fundamental biological processes require concurrent sharing of DNA by numerous motor proteins and complexes. Thus, collision, congestion, and roadblocks are inescapable on these busy "molecular highways." The consequences of these traffic problems are diverse, resulting in complex cellular mechanisms to resolve threats to genome stability and ensure ...
Tung T, Le, Michelle D, Wang
openaire   +3 more sources

Direct and random routing of a molecular motor protein at a DNA junction [PDF]

Nucleic Acids Research, 2006
With the aim of investigating how motor proteins negotiate DNA nanostructures, we produced test circuits based on recombination intermediates in which 1D translocation across a Holliday junction (HJ) could be assessed by subsequent triplex displacement signals on each DNA arm.
Stanley, Louise K., Szczelkun, Mark D.
openaire   +3 more sources

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar, George A. C. Murrell, Millar, N.L., Murrell, G.A.C.   +3 more
core   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Herrmann, Johannes M., Stuart, Rosemary A., Neupert, Walter, Craig, Elisabeth A.   +3 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends [PDF]

, 2012
Archaeal chromatin proteins share molecular and functional similarities with both bacterial and eukaryotic chromatin proteins. These proteins play an important role in functionally organizing the genomic DNA into a compact nucleoid.
White, Malcolm F., Meng, He, van Noort, John, Noort, S.J.T. van, Schiessel, Helmut, Shahapure, Rajesh, Lanzani, G., Meng, H., Dame, Remus Th, Driessen, R.P.C., Shahapure, R., Suresh, G., Driessen, Rosalie P. C., Lanzani, Giovanni, Suresh, Gorle, Schiessel, H., Dame, R.T., Priyakumar, U. Deva, Priyakumar, U.D., White, M.F., White, Malcolm F.; id_orcid   +20 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source