Results 1 to 10 of about 38,190 (209)

Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal

mSphere, 2019
Mitotic spindles assume a bipolar architecture through the concerted actions of microtubules, motors, and cross-linking proteins. In most eukaryotes, kinesin-5 motors are essential to this process, and cells will fail to form a bipolar spindle without ...
Irsa Shoukat, Corey Frazer, John S. Allingham   +2 more
doaj   +1 more source

Competition between kinesin-1 and myosin-V defines Drosophila posterior determination

eLife, 2020
Local accumulation of oskar (osk) mRNA in the Drosophila oocyte determines the posterior pole of the future embryo. Two major cytoskeletal components, microtubules and actin filaments, together with a microtubule motor, kinesin-1, and an actin motor ...
Wen Lu, Margot Lakonishok, Rong Liu, Neil Billington, Ashley Rich, Michael Glotzer, James R Sellers, Vladimir I Gelfand   +7 more
doaj   +1 more source

Deciphering the role of tubulin’s C-terminal tail in kinesin binding using computational and clustering approaches

Scientific Reports
The C-terminal tails (CTTs) of αβ-tubulin heterodimer are intrinsically disordered regions (IDRs) which play critical roles in regulating the processivity and velocity of kinesin walking along microtubule.
Ting Shen, Yuyan Li, Yangle Li, Jingjing Zhao, Jianxin Ma, Haojie Cheng, Jiayi Zhang, Meng Zhou, Wei Zheng, Dehua Hu, Lin Li, Kefu Liu, Shengjie Sun   +12 more
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Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport. [PDF]

PLoS ONE, 2011
In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at the hyphal tip. Less clear is how different microtubule-based and actin-based motors work together to support this growth. Here we
Jun Zhang, Kaeling Tan, Xufeng Wu, Guifang Chen, Jinjin Sun, Samara L Reck-Peterson, John A Hammer, Xin Xiang   +7 more
doaj   +1 more source

Optogenetic control of kinesin-1, -2, -3 and dynein reveals their specific roles in vesicular transport

Cell Reports
Summary: Each cargo in a cell employs a unique set of motor proteins for its transport. To dissect the roles of each type of motor, we developed optogenetic inhibitors of endogenous kinesin-1, -2, -3 and dynein motors and examined their effect on the ...
Sahil Nagpal, Karthikeyan Swaminathan, Daniel Beaudet, Maud Verdier, Samuel Wang, Christopher L. Berger, Florian Berger, Adam G. Hendricks   +7 more
doaj   +1 more source

Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway

Science Progress, 2023
Kinesin family member 3A is an important motor protein that participates in various physiological and pathological processes, including normal tissue development, homeostasis maintenance, tumor infiltration, and migration.
Shupeng Liu, Yang He, Shifeng Li, Xuemin Gao, Fang Yang   +4 more
doaj   +1 more source

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

Nature Communications, 2017
Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule ...
Sergio A. Rincon, Adam Lamson, Robert Blackwell, Viktoriya Syrovatkina, Vincent Fraisier, Anne Paoletti, Meredith D. Betterton, Phong T. Tran   +7 more
doaj   +1 more source

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

Nature Communications, 2017
Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that ...
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang, Benoît Gigant   +6 more
doaj   +1 more source

A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport

Nature Communications
Heterotrimeric kinesin-2, composed of two distinct kinesin motors and a kinesin-associated protein (KAP), is essential for intraflagellar transport and ciliogenesis.
Jinqi Ren, Lingyan Zhao, Guanghan Chen, Guangshuo Ou, Wei Feng   +4 more
doaj   +1 more source

Mechanism of Processive Movement of Monomeric and Dimeric Kinesin Molecules

International Journal of Biological Sciences, 2010
Kinesin molecules are motor proteins capable of moving along microtubule by hydrolyzing ATP. They generally have several forms of construct. This review focuses on two of the most studied forms: monomers such as KIF1A (kinesin-3 family) and dimers such ...
Ping Xie
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