Results 1 to 10 of about 50,612 (251)

A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. [PDF]

PLoS ONE, 2012
Cytoplasmic dynein and kinesin are two-headed microtubule motor proteins that move in opposite directions on microtubules. It is known that kinesin steps by a 'hand-over-hand' mechanism, but it is unclear by which mechanism dynein steps.
Keitaro Shibata, Michi Miura, Yuta Watanabe, Kei Saito, Atsuko Nishimura, Ken'ya Furuta, Yoko Y Toyoshima   +6 more
doaj   +1 more source

Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal

mSphere, 2019
Mitotic spindles assume a bipolar architecture through the concerted actions of microtubules, motors, and cross-linking proteins. In most eukaryotes, kinesin-5 motors are essential to this process, and cells will fail to form a bipolar spindle without ...
Irsa Shoukat, Corey Frazer, John S. Allingham   +2 more
doaj   +1 more source

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Nature Communications, 2021
Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
Adam R. Fenton, Cecilia R. Petruconis, Thomas A. Jongens, Erika L. F. Holzbaur   +3 more
doaj   +1 more source

Dynamics of heterodimeric kinesins and cooperation of kinesins

, 2004
18 pages, 5 ...
Xie, Ping, Dou, Shuo-Xing, Wang, Peng-Ye
openaire   +2 more sources

Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity

Cell Reports, 2018
Summary: Cryptococcus is the most important cause of fungal meningitis in immunocompromised individuals. Host defense against Cryptococcus involves direct killing by NK cells.
Henry Ogbomo, Martina Timm-McCann, Tavish Barnes, Richard F. Xiang, Khusraw Jamil, Anutosh Ganguly, Danuta Stack, Shaunna M. Huston, Shu Shun Li, Pina Colarusso, Christopher H. Mody   +10 more
doaj   +1 more source

Competition between kinesin-1 and myosin-V defines Drosophila posterior determination

eLife, 2020
Local accumulation of oskar (osk) mRNA in the Drosophila oocyte determines the posterior pole of the future embryo. Two major cytoskeletal components, microtubules and actin filaments, together with a microtubule motor, kinesin-1, and an actin motor ...
Wen Lu, Margot Lakonishok, Rong Liu, Neil Billington, Ashley Rich, Michael Glotzer, James R Sellers, Vladimir I Gelfand   +7 more
doaj   +1 more source

Oncogenic role of kinesin proteins and targeting kinesin therapy

Cancer Science, 2013
The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor domain. Except for some members, many KIF proteins have adenosine triphosphatase activity and microtubule‐dependent plus‐end motion ability. Kinesins participate in several essential cellular functions, including mitosis, meiosis and the transport of macromolecules.
Xinran, Liu, Hao, Gong, Kun, Huang
openaire   +3 more sources

Optogenetic control of kinesin-1, -2, -3 and dynein reveals their specific roles in vesicular transport

Cell Reports
Summary: Each cargo in a cell employs a unique set of motor proteins for its transport. To dissect the roles of each type of motor, we developed optogenetic inhibitors of endogenous kinesin-1, -2, -3 and dynein motors and examined their effect on the ...
Sahil Nagpal, Karthikeyan Swaminathan, Daniel Beaudet, Maud Verdier, Samuel Wang, Christopher L. Berger, Florian Berger, Adam G. Hendricks   +7 more
doaj   +1 more source

Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport. [PDF]

PLoS ONE, 2011
In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at the hyphal tip. Less clear is how different microtubule-based and actin-based motors work together to support this growth. Here we
Jun Zhang, Kaeling Tan, Xufeng Wu, Guifang Chen, Jinjin Sun, Samara L Reck-Peterson, John A Hammer, Xin Xiang   +7 more
doaj   +1 more source

A standardized kinesin nomenclature [PDF]

The Journal of Cell Biology, 2004
In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin nomenclature based on 14 family designations. The scheme unifies all previous phylogenies and nomenclature proposals, while allowing individual sequence ...
Lawrence, Carolyn J, Dawe, R Kelly, Christie, Karen R, Cleveland, Don W, Dawson, Scott C, Endow, Sharyn A, Goldstein, Lawrence SB, Goodson, Holly V, Hirokawa, Nobutaka, Howard, Jonathon, Malmberg, Russell L, McIntosh, J Richard, Miki, Harukata, Mitchison, Timothy J, Okada, Yasushi, Reddy, Anireddy SN, Saxton, William M, Schliwa, Manfred, Scholey, Jonathan M, Vale, Ronald D, Walczak, Claire E, Wordeman, Linda   +21 more
openaire   +4 more sources