Results 1 to 10 of about 39,214 (117)
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3 [PDF]
eLifeBidirectional cargo transport by kinesin and dynein is essential for cell viability, and defects are linked to neurodegenerative disease. Computational models predict that load-dependent motor detachment strongly determines the outcome of kinesin–dynein ...
Crystal R Noell +4 more
doaj +2 more sources
Mitochondria-Adaptor TRAK1 Promotes Kinesin-1 Driven Transport in Crowded Environments
Nature Communications, 2020 Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates ...
Jakub Rohlena +2 more
exaly +2 more sources
Deciphering the role of tubulin’s C-terminal tail in kinesin binding using computational and clustering approaches [PDF]
Scientific ReportsThe C-terminal tails (CTTs) of αβ-tubulin heterodimer are intrinsically disordered regions (IDRs) which play critical roles in regulating the processivity and velocity of kinesin walking along microtubule.
Ting Shen +12 more
doaj +2 more sources
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
doaj +1 more source
Open Biology, 2022 The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family.
Hannah R. Belsham +5 more
doaj +1 more source
Effect of the Neck Linker on Processive Stepping of Kinesin Motor
Biophysica, 2023 Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
doaj +1 more source
An essential farnesylated kinesin in Trypanosoma brucei. [PDF]
PLoS ONE, 2011 Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson +2 more
doaj +1 more source
microPublication Biology, 2022 We previously showed that the silkworm holocentric spindles are square-shaped, compared to the canonical oval shape of human monocentric spindles (Vanpoperinghe et al. 2021). Further, while kinesin-5 depletion resulted in monopolar spindles in both cells,
Inaara T. Kassamaly +3 more
doaj +1 more source
eLife, 2022 Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1.
Allison M Gicking +6 more
doaj +1 more source
Scientific Reports, 2022 Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to its load and usually move towards microtubule minus ends, whilst most other kinesins have a C-terminal tail and move towards plus ends.
Masahiko Yamagishi +3 more
doaj +1 more source