Results 41 to 50 of about 50,612 (251)

Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs

BMC Biology, 2022
Background Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular transport.
Pushpanjali Soppina, Nishaben Patel, Dipeshwari J. Shewale, Ashim Rai, Sivaraj Sivaramakrishnan, Pradeep K. Naik, Virupakshi Soppina   +6 more
doaj   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Kopajtich, R., Rüdiger Neef, Nigg, E. A., Robert Kopajtich, Mayer, T. U., Thomas U. Mayer, Christian Preisinger, Preisinger, C., Neef, R., Sutcliffe, J., Barr, F. A., Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +20 more
core   +1 more source

Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]

, 1999
Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G., Manfred Schliwa, Schliwa, M., Günther Woehlke, Jochen Kirchner, Kirchner, J.   +5 more
core   +1 more source

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

PLoS Pathogens, 2019
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some ...
Mohammad Zeeshan, Fiona Shilliday, Tianyang Liu, Steven Abel, Tobias Mourier, David J P Ferguson, Edward Rea, Rebecca R Stanway, Magali Roques, Desiree Williams, Emilie Daniel, Declan Brady, Anthony J Roberts, Anthony A Holder, Arnab Pain, Karine G Le Roch, Carolyn A Moores, Rita Tewari   +17 more
doaj   +1 more source

Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array [PDF]

, 2011
The polarity of microtubules (MTs) determines the motors for intracellular motility, with kinesins moving to plus ends and dynein to minus ends. In elongated cells of Ustilago maydis, dynein is thought to move early endosomes (EEs) toward the septum ...
S Kilaru (19426795), G Steinberg (13284030), J Collemare (21925268), G Fink (13609282), M Schuster (7676525), Y Roger (21845105)   +5 more
core   +6 more sources

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development

BMC Plant Biology, 2021
Background Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit ...
Shujuan Tian, Jiao Jiang, Guo-qi Xu, Tan Wang, Qiyan Liu, Xiner Chen, Man Liu, Li Yuan   +7 more
doaj   +1 more source

Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]

Current Biology, 2014
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
openaire   +2 more sources

The crowding dynamics of the motor protein kinesin-II.

PLoS ONE, 2020
Intraflagellar transport (IFT) in C. elegans chemosensory cilia is an example of functional coordination and cooperation of two motor proteins with distinct motility properties operating together in large groups to transport cargoes: a fast and ...
Vandana S Kushwaha, Seyda Acar, Daniël M Miedema, Dmitry V Denisov, Peter Schall, Erwin J G Peterman   +5 more
doaj   +1 more source

Kinesin-13 associates with axonemes in male gametocytes and gametes and its knockdown affects male gamete formation.

, 2022
(A) Expansion microscopy showing colocalisation of kinesin-13 (green) with α/β tubulin staining (purple) in gametocytes activated for 15 min. Scale bar = 5 μm.
Anthony A. Holder (53358), Rita Tewari (134257), Sue Vaughan (20216), Steven Abel (7484636), Zeinab Chahine (13170045), Ravish Rashpa (4278514), Mohammad Zeeshan (141644), Carolyn A. Moores (7484654), Karine G. Le Roch (7373171), David J. P. Ferguson (7484639), Declan Brady (134247), Mathieu Brochet (149272)   +11 more
core   +1 more source

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle

Biomolecules
At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
doaj   +1 more source