Results 31 to 40 of about 47,063 (259)

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development

BMC Plant Biology, 2021
Background Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit ...
Shujuan Tian, Jiao Jiang, Guo-qi Xu, Tan Wang, Qiyan Liu, Xiner Chen, Man Liu, Li Yuan   +7 more
doaj   +1 more source

The crowding dynamics of the motor protein kinesin-II.

PLoS ONE, 2020
Intraflagellar transport (IFT) in C. elegans chemosensory cilia is an example of functional coordination and cooperation of two motor proteins with distinct motility properties operating together in large groups to transport cargoes: a fast and ...
Vandana S Kushwaha, Seyda Acar, Daniël M Miedema, Dmitry V Denisov, Peter Schall, Erwin J G Peterman   +5 more
doaj   +1 more source

Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei. [PDF]

PLoS Pathogens, 2010
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies ...
Kuan Yoow Chan, Keith R Matthews, Klaus Ersfeld   +2 more
doaj   +1 more source

Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]

Current Biology, 2014
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
openaire   +2 more sources

Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor

Cancer Informatics, 2008
We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Aimee L. Jackson, Mao Mao, Sumire Kobayashi, Teresa Ward, Matthew Biery, Hongyue Dai, Steven R. Bartz, Peter S. Linsley   +7 more
doaj   +1 more source

Characterization of Motility Properties of Kinesin-Driven Microtubules Towards Nano-Scale Transporter: Focusing on Length of Microtubules and Kinesin Density

Journal of Biomechanical Science and Engineering, 2008
Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA, Naoya SAKAMOTO, Toshiro OHASHI, Masaaki SATO   +3 more
doaj   +1 more source

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]

, 2006
The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
James E. Evans, Kent L. McDonald, Amy L. Gunnarson, Gunnarson, Amy L., Guangshuo Ou, Snow, JJ, McDonald, KL, Stahlberg, Henning, Ou, Guangshuo, Ou, GS, Evans, JE, Stahlberg, H, Evans, James E., Jonathan M. Scholey, Scholey, JM, Gunnarson, AL, McDonald, Kent L., Joshua J. Snow, Henning Stahlberg, Snow, Joshua J., Scholey, Jonathan M.   +20 more
core   +1 more source

Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection.

, 2022
Intracellular mature virus (IMV) are the first and most abundant infectious form of vaccinia virus to assemble during its replication cycle. IMV can undergo microtubule-based motility, but their directionality and the motor involved in their transport ...
Timothy P Newsome (13916763), Amadeus Xu (13916760), Angika Basant (4376254), Sibylle Schleich (371798), Michael Way (255647)   +4 more
core   +1 more source

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle

Biomolecules
At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
doaj   +1 more source

The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. [PDF]

PLoS ONE, 2010
Kinesin-13 proteins have a critical role in animal cell mitosis, during which they regulate spindle microtubule dynamics through their depolymerisation activity.
Bill Wickstead, Jamie T Carrington, Eva Gluenz, Keith Gull   +3 more
doaj   +1 more source