Results 31 to 40 of about 38,190 (209)

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

PLoS Pathogens, 2019
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some ...
Mohammad Zeeshan, Fiona Shilliday, Tianyang Liu, Steven Abel, Tobias Mourier, David J P Ferguson, Edward Rea, Rebecca R Stanway, Magali Roques, Desiree Williams, Emilie Daniel, Declan Brady, Anthony J Roberts, Anthony A Holder, Arnab Pain, Karine G Le Roch, Carolyn A Moores, Rita Tewari   +17 more
doaj   +1 more source

Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]

Current Biology, 2014
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
openaire   +2 more sources

The crowding dynamics of the motor protein kinesin-II.

PLoS ONE, 2020
Intraflagellar transport (IFT) in C. elegans chemosensory cilia is an example of functional coordination and cooperation of two motor proteins with distinct motility properties operating together in large groups to transport cargoes: a fast and ...
Vandana S Kushwaha, Seyda Acar, Daniël M Miedema, Dmitry V Denisov, Peter Schall, Erwin J G Peterman   +5 more
doaj   +1 more source

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development

BMC Plant Biology, 2021
Background Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit ...
Shujuan Tian, Jiao Jiang, Guo-qi Xu, Tan Wang, Qiyan Liu, Xiner Chen, Man Liu, Li Yuan   +7 more
doaj   +1 more source

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle

Biomolecules
At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
doaj   +1 more source

Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei. [PDF]

PLoS Pathogens, 2010
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies ...
Kuan Yoow Chan, Keith R Matthews, Klaus Ersfeld   +2 more
doaj   +1 more source

Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor

Cancer Informatics, 2008
We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Aimee L. Jackson, Mao Mao, Sumire Kobayashi, Teresa Ward, Matthew Biery, Hongyue Dai, Steven R. Bartz, Peter S. Linsley   +7 more
doaj   +1 more source

Characterization of Motility Properties of Kinesin-Driven Microtubules Towards Nano-Scale Transporter: Focusing on Length of Microtubules and Kinesin Density

Journal of Biomechanical Science and Engineering, 2008
Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA, Naoya SAKAMOTO, Toshiro OHASHI, Masaaki SATO   +3 more
doaj   +1 more source

The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. [PDF]

PLoS ONE, 2010
Kinesin-13 proteins have a critical role in animal cell mitosis, during which they regulate spindle microtubule dynamics through their depolymerisation activity.
Bill Wickstead, Jamie T Carrington, Eva Gluenz, Keith Gull   +3 more
doaj   +1 more source

A look into kinesin's powerhouse [PDF]

FEBS Letters, 2001
Kinesins are microtubule‐dependent motors that serve a multitude of cellular purposes. The conserved motor domain provides the energy required for these processes. Shortly after the solution of the first kinesin motor domain crystal structures the similarity to myosin and G‐proteins was noted.
openaire   +2 more sources