Results 31 to 40 of about 51,301 (248)

Kinesin-13 associates with axonemes in male gametocytes and gametes and its knockdown affects male gamete formation.

, 2022
(A) Expansion microscopy showing colocalisation of kinesin-13 (green) with α/β tubulin staining (purple) in gametocytes activated for 15 min. Scale bar = 5 μm.
Anthony A. Holder (53358), Rita Tewari (134257), Sue Vaughan (20216), Steven Abel (7484636), Zeinab Chahine (13170045), Ravish Rashpa (4278514), Mohammad Zeeshan (141644), Carolyn A. Moores (7484654), Karine G. Le Roch (7373171), David J. P. Ferguson (7484639), Declan Brady (134247), Mathieu Brochet (149272)   +11 more
core   +1 more source

Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs

BMC Biology, 2022
Background Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular transport.
Pushpanjali Soppina, Nishaben Patel, Dipeshwari J. Shewale, Ashim Rai, Sivaraj Sivaramakrishnan, Pradeep K. Naik, Virupakshi Soppina   +6 more
doaj   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

Kinesin-13 associates with kinetochore marker, NDC80, during various proliferative stages of parasite life cycle.

, 2022
Live cell imaging showing location of kinesin-13GFP (green) with respect to kinetochore marker NDC80Cherry (red) during asexual (A, B) and sexual (C, D) proliferative stages.
Anthony A. Holder (53358), Rita Tewari (134257), Sue Vaughan (20216), Steven Abel (7484636), Zeinab Chahine (13170045), Ravish Rashpa (4278514), Mohammad Zeeshan (141644), Carolyn A. Moores (7484654), Karine G. Le Roch (7373171), David J. P. Ferguson (7484639), Declan Brady (134247), Mathieu Brochet (149272)   +11 more
core   +1 more source

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

PLoS Pathogens, 2019
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some ...
Mohammad Zeeshan, Fiona Shilliday, Tianyang Liu, Steven Abel, Tobias Mourier, David J P Ferguson, Edward Rea, Rebecca R Stanway, Magali Roques, Desiree Williams, Emilie Daniel, Declan Brady, Anthony J Roberts, Anthony A Holder, Arnab Pain, Karine G Le Roch, Carolyn A Moores, Rita Tewari   +17 more
doaj   +1 more source

Kinesin-II motility under crowded conditions.

, 2020
A. Schematic of the in vitro motility assay. kinesin-II motors walk along the microtubules attached to the glass slide. The fluorescently labeled motor proteins are excited and imaged using TIRF microscopy. B.
Daniël M. Miedema (8447271), Erwin J. G. Peterman (8447277), Dmitry V. Denisov (8447274), Vandana S. Kushwaha (8447265), Seyda Acar (8447268), Peter Schall (2998305)   +5 more
core   +1 more source

Speed effects in gliding motility assays due to surface passivation, water isotope, and osmotic stress. [PDF]

, 2010
The molecular motor kinesin-1, an ATPase, and the substrate it walks along, microtubules, are vital components of eukaryotic cells. Kinesin converts chemical energy to linear motion as its two motor domains step along microtubules in a process similar to
Steven J. Koch, Andy Maloney, Lawrence J. Herskowitz   +2 more
core   +1 more source

Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development

BMC Plant Biology, 2021
Background Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit ...
Shujuan Tian, Jiao Jiang, Guo-qi Xu, Tan Wang, Qiyan Liu, Xiner Chen, Man Liu, Li Yuan   +7 more
doaj   +1 more source

Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]

Current Biology, 2014
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
openaire   +2 more sources

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle

Biomolecules
At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
doaj   +1 more source