Results 11 to 20 of about 38,190 (209)
The mechanism of kinesin inhibition by kinesin-binding protein [PDF]
eLife, 2020 Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton +8 more
doaj +6 more sources
Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
Nature Communications, 2020 Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates ...
Jakub Rohlena +2 more
exaly +2 more sources
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
doaj +1 more source
Open Biology, 2022 The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family.
Hannah R. Belsham +5 more
doaj +1 more source
Effect of the Neck Linker on Processive Stepping of Kinesin Motor
Biophysica, 2023 Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
doaj +1 more source
An essential farnesylated kinesin in Trypanosoma brucei. [PDF]
PLoS ONE, 2011 Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson +2 more
doaj +1 more source
Kinesin transport: driving kinesin in the neuron [PDF]
Current Biology, 2001 A plethora of cytoplasmic motors contribute to the directed transport of a wide range of cellular organelles and molecules. Recent studies have advanced our understanding of cargo attachment to motor molecules and the regulation of intracellular transport.
Hays, Tom, Li, Min-gang
openaire +2 more sources
The functions of kinesin and kinesin-related proteins in eukaryotes [PDF]
Cell Adhesion & Migration, 2020 Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis ...
Iftikhar Ali, Wei-Cai Yang
openaire +3 more sources
eLife, 2022 Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1.
Allison M Gicking +6 more
doaj +1 more source
Scientific Reports, 2022 Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to its load and usually move towards microtubule minus ends, whilst most other kinesins have a C-terminal tail and move towards plus ends.
Masahiko Yamagishi +3 more
doaj +1 more source