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Kinesins in spermatogenesis† [PDF]
Biology of Reproduction, 2017 Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Dan-Dan, Ma, Da-Hui, Wang, Wan-Xi, Yang
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Journal of Cell Science, 2010 Kinesin was discovered in 1985 – 25 years ago – based on its motility in cytoplasm extruded from the giant axon of the squid ([Allen et al., 1982][1]; [Brady et al., 1982][2]; [Vale et al., 1985][3]).
Endow, Sharyn A +2 more
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Nature, 1996 Chromosome segregation during mitosis depends on the action of the mitotic spindle, a self-organizing, bipolar protein machine which uses microtubules (MTs) and their associated motors. Members of the BimC subfamily of kinesin-related MT-motor proteins are believed to be essential for the formation and functioning of a normal bipolar spindle.
Kashina, A. S +5 more
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Recycling of kinesin-1 motors by diffusion after transport. [PDF]
PLoS ONE, 2013 Kinesin motors drive the long-distance anterograde transport of cellular components along microtubule tracks. Kinesin-dependent transport plays a critical role in neurogenesis and neuronal function due to the large distance separating the soma and nerve ...
T Lynne Blasius +3 more
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Electrostatically biased binding of kinesin to microtubules. [PDF]
PLoS Biology, 2011 The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Barry J Grant +7 more
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Kinesin as an Electrostatic Machine [PDF]
Journal of Biological Physics, 2006 Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time varying charge distributions furnished by the ATP hydrolysis circle while the static charge configuration on the microtuble ...
Alva, Aleix +2 more
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Cell Reports, 2019 Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan +9 more
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Frontiers in Cellular and Infection Microbiology, 2020 Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan +5 more
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Motor generated torque drives coupled yawing and orbital rotations of kinesin coated gold nanorods
Communications Biology, 2022 In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Mitsuhiro Sugawa +4 more
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Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs
BMC Biology, 2022 Background Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular transport.
Pushpanjali Soppina +6 more
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