Results 21 to 30 of about 47,063 (259)

Motor generated torque drives coupled yawing and orbital rotations of kinesin coated gold nanorods

Communications Biology, 2022
In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Mitsuhiro Sugawa, Yohei Maruyama, Masahiko Yamagishi, Robert A. Cross, Junichiro Yajima   +4 more
doaj   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity. [PDF]

J Neurochem
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Turner ED, Twelvetrees AE.
europepmc   +2 more sources

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites

Frontiers in Cellular and Infection Microbiology, 2020
Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan, Declan Brady, Rebecca R. Stanway, Carolyn A. Moores, Anthony A. Holder, Rita Tewari   +5 more
doaj   +1 more source

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Cell Reports, 2019
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]

, 2000
The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Mandelkow, Eckhard, Song, Young Hwa, Woehlke, Guenther, Tittmann, Peter, Hoenger, Andreas, Gross, Heinz, Doerhoefer, Monika   +6 more
core   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs

BMC Biology, 2022
Background Kinesin-3 family motors drive diverse cellular processes and have significant clinical importance. The ATPase cycle is integral to the processive motility of kinesin motors to drive long-distance intracellular transport.
Pushpanjali Soppina, Nishaben Patel, Dipeshwari J. Shewale, Ashim Rai, Sivaraj Sivaramakrishnan, Pradeep K. Naik, Virupakshi Soppina   +6 more
doaj   +1 more source

Kinesin-13 associates with axonemes in male gametocytes and gametes and its knockdown affects male gamete formation.

, 2022
(A) Expansion microscopy showing colocalisation of kinesin-13 (green) with α/β tubulin staining (purple) in gametocytes activated for 15 min. Scale bar = 5 μm.
Anthony A. Holder (53358), Rita Tewari (134257), Sue Vaughan (20216), Steven Abel (7484636), Zeinab Chahine (13170045), Ravish Rashpa (4278514), Mohammad Zeeshan (141644), Carolyn A. Moores (7484654), Karine G. Le Roch (7373171), David J. P. Ferguson (7484639), Declan Brady (134247), Mathieu Brochet (149272)   +11 more
core   +1 more source

Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]

, 1999
Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G., Manfred Schliwa, Schliwa, M., Günther Woehlke, Jochen Kirchner, Kirchner, J.   +5 more
core   +1 more source

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.

PLoS Pathogens, 2019
Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some ...
Mohammad Zeeshan, Fiona Shilliday, Tianyang Liu, Steven Abel, Tobias Mourier, David J P Ferguson, Edward Rea, Rebecca R Stanway, Magali Roques, Desiree Williams, Emilie Daniel, Declan Brady, Anthony J Roberts, Anthony A Holder, Arnab Pain, Karine G Le Roch, Carolyn A Moores, Rita Tewari   +17 more
doaj   +1 more source