Results 21 to 30 of about 51,301 (248)

Kinesin-14 : the roots of reversal [PDF]

, 2010
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A., Cross Robert A, Robert A Cross   +2 more
core   +1 more source

The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]

, 2014
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni, Singleton, Martin R., Carter, Nicholas J., Toni McHugh, Hauke Drechsler, Nicholas J Carter, Drechsler, Hauke, McAinsh, Andrew D., Martin R Singleton, Andrew D McAinsh   +9 more
core   +1 more source

Kinesin as an Electrostatic Machine [PDF]

Journal of Biological Physics, 2006
Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time varying charge distributions furnished by the ATP hydrolysis circle while the static charge configuration on the microtuble ...
Alva, Aleix, Sancho Herrero, José María, Tsironis, Giorgos P.   +2 more
openaire   +5 more sources

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Rüdiger Neef, Robert Kopajtich, Thomas U. Mayer, Christian Preisinger, Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +13 more
core   +1 more source

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Cell Reports, 2019
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad   +9 more
doaj   +1 more source

MAPping out distribution routes for kinesin couriers [PDF]

, 2013
In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins.
Moores, Carolyn A., Houdusse, A., Atherton, Joseph, Joseph Atherton, Carolyn Moores, Anne Houdusse   +5 more
core   +1 more source

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites

Frontiers in Cellular and Infection Microbiology, 2020
Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan, Declan Brady, Rebecca R. Stanway, Carolyn A. Moores, Anthony A. Holder, Rita Tewari   +5 more
doaj   +1 more source

Motor generated torque drives coupled yawing and orbital rotations of kinesin coated gold nanorods

Communications Biology, 2022
In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Mitsuhiro Sugawa, Yohei Maruyama, Masahiko Yamagishi, Robert A. Cross, Junichiro Yajima   +4 more
doaj   +1 more source

Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]

, 1999
Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G., Manfred Schliwa, Schliwa, M., Günther Woehlke, Jochen Kirchner, Kirchner, J.   +5 more
core   +1 more source