Results 21 to 30 of about 82,635 (293)
Proceedings of the National Academy of Sciences, 2004 We have identified dimeric kinesin mutants that become stalled on the microtubule after one ATP turnover, unable to bind and hydrolyze ATP at their second site. We have used these mutants to determine the regulatory signal that allows ATP to bind to the forward head, such that processive movement can continue.
Lisa M, Klumpp +2 more
openaire +2 more sources
Speed effects in gliding motility assays due to surface passivation, water isotope, and osmotic stress. [PDF]
, 2010 The molecular motor kinesin-1, an ATPase, and the substrate it walks along, microtubules, are vital components of eukaryotic cells. Kinesin converts chemical energy to linear motion as its two motor domains step along microtubules in a process similar to
Andy Maloney +2 more
core +2 more sources
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]
, 2014 Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline +5 more
core +3 more sources
Kinesins in spermatogenesis†[PDF]
Biology of Reproduction, 2017 Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Dan-Dan, Ma, Da-Hui, Wang, Wan-Xi, Yang
openaire +2 more sources
Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
Nature Communications, 2020 Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates ...
Verena Henrichs +8 more
doaj +1 more source
Motor generated torque drives coupled yawing and orbital rotations of kinesin coated gold nanorods
Communications Biology, 2022 In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Mitsuhiro Sugawa +4 more
doaj +1 more source
Kinesin Light Chains Are Essential for Axonal Transport in Drosophila [PDF]
, 1998 Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood.
Beushausen, Sven +4 more
core +2 more sources
Microtubule-regulating kinesins [PDF]
Current Biology, 2013 Kinesins can regulate microtubule dynamics? The conventional function of kinesins, much like a molecular freight train, is to transport cargo by motoring along a microtubule (MT) track. But there exists another class of kinesins whose job relates more to track maintenance than transportation.
Sturgill, Emma G., Ohi, Ryoma
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2020 Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation.
Mohammad Zeeshan +5 more
doaj +1 more source
Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]
, 1991 The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K +6 more
core +2 more sources