Results 71 to 80 of about 5,860,920 (296)

Structural and molecular changes in the epicenter of injury and distant segments of the rat spinal cord in response to rehabilitative motor training

Acta Biomedica Scientifica
Background. Spinal cord injury (SCI) leads to partial or complete loss of sensory and/or  motor functions below the injury site due to neuron and glial cell death, axonal degeneration, and disruption of the blood-spinal cord barrier (BSCB).
D. Kh. Sabirov, T. V. Ageeva, A. V. Timofeeva, E. A. Plotnikova, S. S. Arkhipova, E. F. Davletshin, Ya. O. Mukhamedshina   +6 more
doaj   +1 more source

Modeling a Microtubule Filaments Mesh Structure from Confocal Microscopy Imaging

Micromachines, 2020
This study introduces a modeling method for a supermolecular structure of microtubules for the development of a force generation material using motor proteins.
Yutaka Ueno, Kento Matsuda, Kaoru Katoh, Akinori Kuzuya, Akira Kakugo, Akihiko Konagaya   +5 more
doaj   +1 more source

Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment

Frontiers in Human Neuroscience, 2022
By age 85, most adults manifest some degree of motor impairment. However, in most individuals a specific etiology for motor decline and treatment to modify its inexorable progression cannot be identified.
Aron S. Buchman, Aron S. Buchman, David A. Bennett, David A. Bennett   +3 more
doaj   +1 more source

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs [PDF]

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
E. M. Makarov (7607225), Evgeny M. Makarov, Andrew Bottrill, O. V. Makarova (7607222), Makarov, EM, Bottrill, A, N. Owen (7618997), Owen, N, Olga V. Makarova, Makarova, OV, A. Bottrill (7622258), Nicholas Owen   +11 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Hsp70 at the membrane: driving protein translocation

BMC Biology, 2018
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—such as those in the membranes of the ...
Elizabeth A. Craig
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Neurobiology of Disease, 2011
Expression of mutant SOD1 typical of familial amyotrophic lateral sclerosis (ALS) induces the expression of Bcl2-A1, a member of the Bcl2 family of proteins, specifically in motor neurons of transgenic mice.In this work, we have used immortalized motor ...
Ciro Iaccarino, Maria Elena Mura, Sonia Esposito, Franco Carta, Giovanna Sanna, Franco Turrini, Maria Teresa Carrì, Claudia Crosio   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source