Results 81 to 90 of about 5,860,920 (296)

An archaellum filament composed of two alternating subunits

Nature Communications, 2022
The archaellum is a molecular machine used by archaea to swim, consisting of an intracellular motor that drives the rotation of an extracellular filament composed of multiple copies of proteins named archaellins.
Lavinia Gambelli, Michail N. Isupov, Rebecca Conners, Mathew McLaren, Annett Bellack, Vicki Gold, Reinhard Rachel, Bertram Daum   +7 more
doaj   +1 more source

Electrostatically biased binding of kinesin to microtubules [PDF]

, 2011
The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Zheng Wenjun, Zheng, Wenjun, Grant, Barry J, McCammon, J. Andrew, Grant, Barry J., Gary Huber, McCammon, J Andrew, Dlugosz, Maciej, Maria Alonso, Huber, Gary, McCammon J. Andrew, Maciej Dlugosz, Barry J. Grant, J Andrew McCammon, Robert A. Cross, Gheorghe, Dana M, Cross, R. A., M. Gheorghe Dana, Wenjun Zheng, Barry J Grant, Alonso, M. (Maria), Alonso Maria, Robert A Cross, J. Andrew McCammon, Dana M Gheorghe, Dana M. Gheorghe, Cross Robert A., Alonso, Maria, Grant Barry J., Huber Gary, Cross, Robert A, Gheorghe, Dana M., Dlugosz Maciej   +32 more
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Common Functional Dynamics of Molecular Motor and Switch Proteins [PDF]

Biophysical Journal, 2013
Understanding how protein ligand binding can promote distinct conformational states, with different affinities for binding partners, is key to understanding the structural basis of protein efficacy. Here we study eight molecular motor and G-protein families that undergo GTP or ATP associated conformational changes to regulate important cell processes ...
Scarabelli, Guido, Grant, Barry J.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Active spiralling of microtubules driven by kinesin motors

Scientific Reports
Cytoskeletal filaments propelled by surface-bound motor proteins can be viewed as active polymers, a class of active matter. When constraints are imposed on their movements, the propelled cytoskeletal filaments show dynamic patterns distinct from ...
Douglas Kagoiya Ng’ang’a, Samuel Macharia Kang’iri, Henry Hess, Takahiro Nitta   +3 more
doaj   +1 more source

Reconstitution of dynein transport to the microtubule plus end by kinesin

eLife, 2014
Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Anthony J Roberts, Brian S Goodman, Samara L Reck-Peterson   +2 more
doaj   +1 more source

Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases

Frontiers in Cell and Developmental Biology, 2020
Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport ...
Benjamin Vitre, Audrey Guesdon, Benedicte Delaval   +2 more
doaj   +1 more source

Um modelo simplificado para a dinâmica de motores moleculares [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matermáticas, Programa de Pós-Graduação em Física, Florianópolis, 2015.Neste trabalho desenvolvemos um estudo sobre motores moleculares.
Ferreira, Luiza Gomes
core  

Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]

, 2012
The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core   +1 more source