Results 91 to 100 of about 230,773 (293)
Characterization of microtubules and motor proteins via molecular dynamics simulations. [PDF]
, 2006 Microtubules and related motor proteins such as kinesins or dyneins are cytoskeleton structures in many different physiological processes in eukaryotes.
Aprodu, Iuliana +6 more
core
Active spiralling of microtubules driven by kinesin motors
Scientific ReportsCytoskeletal filaments propelled by surface-bound motor proteins can be viewed as active polymers, a class of active matter. When constraints are imposed on their movements, the propelled cytoskeletal filaments show dynamic patterns distinct from ...
Douglas Kagoiya Ng’ang’a +3 more
doaj +1 more source
Reconstitution of dynein transport to the microtubule plus end by kinesin
eLife, 2014 Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Anthony J Roberts +2 more
doaj +1 more source
Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
Frontiers in Cell and Developmental Biology, 2020 Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport ...
Benjamin Vitre +2 more
doaj +1 more source
The Common Functional Dynamics of Molecular Motor and Switch Proteins [PDF]
Biophysical Journal, 2013 Understanding how protein ligand binding can promote distinct conformational states, with different affinities for binding partners, is key to understanding the structural basis of protein efficacy. Here we study eight molecular motor and G-protein families that undergo GTP or ATP associated conformational changes to regulate important cell processes ...
Scarabelli, Guido, Grant, Barry J.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PLoS Pathogens, 2010 Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds ...
Gareth W Morgan +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules [PDF]
, 2012 The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here that S.
Muriel Erent (185011) +11 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source