Results 11 to 20 of about 224,088 (260)

Chromatin maintenance by a molecular motor protein [PDF]

Nucleus, 2011
The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Manjari, Mazumdar, Myong-Hee, Sung, Tom, Misteli   +2 more
openaire   +2 more sources

Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior

Frontiers in Cell and Developmental Biology, 2021
Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
doaj   +1 more source

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Acta Pharmaceutica Sinica B, 2021
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang, Kewu Zeng   +9 more
doaj   +1 more source

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

eLife, 2022
Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef, Hisashi Tadakuma, Kangmin Yan, Takashi Fujiwara, Kodai Fukumoto, Yuichi Kondo, Hiroko Takazaki, Rofia Boudria, Takuo Yasunaga, Hideo Higuchi, Keiko Hirose   +10 more
doaj   +1 more source

Construction of a Chassis for a Tripartite Protein-Based Molecular Motor [PDF]

ACS Synthetic Biology, 2017
Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors.
Lara S. R. Small, Marc Bruning, Andrew R. Thomson, Aimee L. Boyle, Roberta B. Davies, Paul M. G. Curmi, Nancy R. Forde, Heiner Linke, Derek N. Woolfson, Elizabeth H. C. Bromley   +9 more
openaire   +6 more sources

A role for myosin VI in the localization of axonal proteins. [PDF]

PLoS Biology, 2011
In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites.
Tommy L Lewis, Tianyi Mao, Don B Arnold
doaj   +1 more source

Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics

Marine Drugs, 2016
Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally located ...
Joseph A. White, Rupkatha Banerjee, Shermali Gunawardena   +2 more
doaj   +1 more source

Synthetic, Protein-Based Molecular Motors [PDF]

Biophysical Journal, 2009
We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J., Zuckermann, Martin J., Curmi, Paul M.G., Bromley, Elizabeth H.C., Donadini, Roberta, Woolfson, Derek N., Forde, Nancy R., Linke, Heiner   +7 more
openaire   +1 more source

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Frontiers in Molecular Biosciences, 2022
Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan   +7 more
doaj   +1 more source

Techniques for studying protein trafficking and molecular motors in neurons [PDF]

Cytoskeleton, 2016
This review focused on techniques that facilitated the visualization of protein trafficking. In the mid‐1990s the cloning of GFP allowed fluorescently tagged proteins to be expressed in cells and then visualized in real time. This advance allowed a glimpse, for the first time, of the complex system within cells for distributing proteins.
Shanxi, Feng, Don B, Arnold
openaire   +2 more sources