Results 11 to 20 of about 5,860,920 (296)

Molecular motor proteins and amyotrophic lateral sclerosis. [PDF]

Int J Mol Sci, 2011
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis.
Soo KY, Farg M, Atkin JD.
europepmc   +5 more sources

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]

Frontiers in Cellular Neuroscience, 2016
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller, Heidi R Fuller, Berhan eMandefro, Berhan eMandefro, Sally L Shirran, Andrew R Gross, Anjoscha Samija Kaus, Catherine H Botting, Glenn E Morris, Glenn E Morris, Dhruv eSareen, Dhruv eSareen, Dhruv eSareen   +12 more
doaj   +2 more sources

Structural Studies on Bacteriophage Portal Proteins [PDF]

, 2013
In tailed bacteriophages and evolutionarily related herpes viruses, the portal protein is a central component of the DNA packaging molecular motor, which translocates viral genomic DNA into a preformed procapsid.
Luan, Weisha
core   +6 more sources

A metal switch for controlling the activity of molecular motor proteins. [PDF]

Nat Struct Mol Biol, 2011
Kinesins are molecular motors that require a divalent metal ion (for example, Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP and report on a serine-to-cysteine substitution in the switch 1 motif of ...
Cochran JC, Zhao YC, Wilcox DE, Kull FJ.
europepmc   +5 more sources

Towards the Application of Cytoskeletal Motor Proteins in Molecular Detection and Diagnostic Devices

Current Opinion in Biotechnology, 2010
Over the past ten years, great advancements have been made towards using biomolecular motors for nanotechnological applications. In particular, devices using cytoskeletal motor proteins for molecular transport are maturing.
Alf Månsson, Stefan Diez, Korten, Till,, Månsson, Alf,, Månsson, A., Till Korten, Korten, T., Diez, S., Diez, Stefan,   +8 more
core   +4 more sources

Chromatin maintenance by a molecular motor protein [PDF]

Nucleus, 2011
The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Manjari, Mazumdar, Myong-Hee, Sung, Tom, Misteli   +2 more
openaire   +2 more sources

The role of motor proteins in endosomal sorting [PDF]

, 2011
Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Sylvie D Hunt, David J Stephens, Stephens, DJ   +3 more
core   +1 more source

Construction of a Chassis for a Tripartite Protein-Based Molecular Motor [PDF]

ACS Synthetic Biology, 2017
Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors.
Lara S. R. Small, Marc Bruning, Andrew R. Thomson, Aimee L. Boyle, Roberta B. Davies, Paul M. G. Curmi, Nancy R. Forde, Heiner Linke, Derek N. Woolfson, Elizabeth H. C. Bromley   +9 more
openaire   +6 more sources

Kinesin-14 : the roots of reversal [PDF]

, 2010
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A., Cross Robert A, Robert A Cross   +2 more
core   +1 more source

Synthetic, Protein-Based Molecular Motors [PDF]

Biophysical Journal, 2009
We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J., Zuckermann, Martin J., Curmi, Paul M.G., Bromley, Elizabeth H.C., Donadini, Roberta, Woolfson, Derek N., Forde, Nancy R., Linke, Heiner   +7 more
openaire   +1 more source