Results 11 to 20 of about 230,773 (293)
Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
doaj +3 more sources
Regeneration of Assembled, Molecular-Motor-Based Bionanodevices [PDF]
, 2019 The guided gliding of cytoskeletal filaments, driven by biomolecular motors on nano/microstructured chips, enables novel applications in biosensing and biocomputation. However, expensive and time-consuming chip production hampers the developments.
Cordula Reuther (2524918) +8 more
core +17 more sources
Cell Reports, 2021 Summary: Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive.
Supriya Swarnkar +12 more
doaj +1 more source
Chromatin maintenance by a molecular motor protein [PDF]
Nucleus, 2011 The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Manjari, Mazumdar +2 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
doaj +1 more source
Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer
Acta Pharmaceutica Sinica B, 2021 Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian +9 more
doaj +1 more source
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
['IDENTIFYING MOLECULAR FUNCTIONS OF DYNEIN MOTOR PROTEINS USING EXTREME GRADIENT BOOSTING ALGORITHM WITH MACHINE LEARNING'] [PDF]
Journal of Mountain Area Research, 2022 The majority of cytoplasmic proteins and vesicles move actively primarily to dynein motor proteins, which are the cause of muscle contraction. Moreover, identifying how dynein are used in cells will rely on structural knowledge.
Ali Ghulam +6 more
doaj +3 more sources
A role for myosin VI in the localization of axonal proteins. [PDF]
PLoS Biology, 2011 In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites.
Tommy L Lewis, Tianyi Mao, Don B Arnold
doaj +1 more source
Construction of a Chassis for a Tripartite Protein-Based Molecular Motor [PDF]
ACS Synthetic Biology, 2017 Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors.
Lara S. R. Small +9 more
openaire +6 more sources