Results 11 to 20 of about 392,762 (297)
Molecular switch-like regulation in motor proteins [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors that enhance or suppress their NTPase activity.
Sara Tafoya, Carlos Bustamante
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Chromatin maintenance by a molecular motor protein [PDF]
Nucleus, 2011 The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Manjari, Mazumdar +2 more
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Multiscale molecular dynamics simulations of rotary motor proteins [PDF]
Biophysical Reviews, 2017 Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing ...
Toru Ekimoto, Mitsunori Ikeguchi
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A role for myosin VI in the localization of axonal proteins. [PDF]
PLoS Biology, 2011 In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites.
Tommy L Lewis, Tianyi Mao, Don B Arnold
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Marine Drugs, 2016 Unlike virtually any other cells in the human body, neurons are tasked with the unique problem of transporting important factors from sites of synthesis at the cell bodies, across enormous distances, along narrow-caliber projections, to distally located ...
Joseph A. White +2 more
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Frontiers in Molecular Biosciences, 2022 Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu +7 more
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Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]
, 1991 The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K +6 more
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Life without double-headed non-muscle myosin II motor proteins
Frontiers in Chemistry, 2014 Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has
Venkaiah eBetapudi
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Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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Differential expression of molecular motors in the motor cortex of sporadic ALS
Neurobiology of Disease, 2007 The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood.
Maria Pantelidou +5 more
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