Results 21 to 30 of about 5,562,063 (299)

Synthetic, Protein-Based Molecular Motors [PDF]

Biophysical Journal, 2009
We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J., Zuckermann, Martin J., Curmi, Paul M.G., Bromley, Elizabeth H.C., Donadini, Roberta, Woolfson, Derek N., Forde, Nancy R., Linke, Heiner   +7 more
openaire   +1 more source

Techniques for studying protein trafficking and molecular motors in neurons [PDF]

Cytoskeleton, 2016
This review focused on techniques that facilitated the visualization of protein trafficking. In the mid‐1990s the cloning of GFP allowed fluorescently tagged proteins to be expressed in cells and then visualized in real time. This advance allowed a glimpse, for the first time, of the complex system within cells for distributing proteins.
Shanxi, Feng, Don B, Arnold
openaire   +2 more sources

Differential expression of molecular motors in the motor cortex of sporadic ALS

Neurobiology of Disease, 2007
The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood.
Maria Pantelidou, Spyros E. Zographos, Carsten W. Lederer, Theodore Kyriakides, Michael W. Pfaffl, Niovi Santama   +5 more
doaj   +1 more source

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Frontiers in Molecular Biosciences, 2022
Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan   +7 more
doaj   +1 more source

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj   +1 more source

Engineered Pendrin Protein, an Anion Transporter and Molecular Motor [PDF]

Journal of Biological Chemistry, 2011
Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
Jie, Tang, Jason L, Pecka, Xiaodong, Tan, Kirk W, Beisel, David Z Z, He   +4 more
openaire   +2 more sources

TRIM3 regulates the motility of the kinesin motor protein KIF21B. [PDF]

PLoS ONE, 2013
Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport involves
Dorthe Labonté, Edda Thies, Yvonne Pechmann, Alexander J Groffen, Matthijs Verhage, August B Smit, Ronald E van Kesteren, Matthias Kneussel   +7 more
doaj   +1 more source

The Ton Motor

Frontiers in Microbiology, 2022
The Ton complex is a molecular motor at the inner membrane of Gram-negative bacteria that uses a proton gradient to apply forces on outer membrane (OM) proteins to permit active transport of nutrients into the periplasmic space.
Anna C. Ratliff, Susan K. Buchanan, Herve Celia   +2 more
doaj   +1 more source

Tumor Formation via Loss of a Molecular Motor Protein [PDF]

Current Biology, 2006
Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy.
Mazumdar, Manjari, Lee, Ji-Hyeon, Sengupta, Kundan, Ried, Thomas, Rane, Sushil, Misteli, Tom   +5 more
openaire   +2 more sources

Multiscale molecular dynamics simulations of rotary motor proteins [PDF]

Biophysical Reviews, 2017
Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing ...
Toru Ekimoto, Mitsunori Ikeguchi
openaire   +2 more sources