Results 21 to 30 of about 224,088 (260)

Differential expression of molecular motors in the motor cortex of sporadic ALS

Neurobiology of Disease, 2007
The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood.
Maria Pantelidou, Spyros E. Zographos, Carsten W. Lederer, Theodore Kyriakides, Michael W. Pfaffl, Niovi Santama   +5 more
doaj   +1 more source

The Ton Motor

Frontiers in Microbiology, 2022
The Ton complex is a molecular motor at the inner membrane of Gram-negative bacteria that uses a proton gradient to apply forces on outer membrane (OM) proteins to permit active transport of nutrients into the periplasmic space.
Anna C. Ratliff, Susan K. Buchanan, Herve Celia   +2 more
doaj   +1 more source

Engineered Pendrin Protein, an Anion Transporter and Molecular Motor [PDF]

Journal of Biological Chemistry, 2011
Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
Jie, Tang, Jason L, Pecka, Xiaodong, Tan, Kirk W, Beisel, David Z Z, He   +4 more
openaire   +2 more sources

TRIM3 regulates the motility of the kinesin motor protein KIF21B. [PDF]

PLoS ONE, 2013
Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport involves
Dorthe Labonté, Edda Thies, Yvonne Pechmann, Alexander J Groffen, Matthijs Verhage, August B Smit, Ronald E van Kesteren, Matthias Kneussel   +7 more
doaj   +1 more source

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj   +1 more source

Multiscale molecular dynamics simulations of rotary motor proteins [PDF]

Biophysical Reviews, 2017
Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing ...
Toru Ekimoto, Mitsunori Ikeguchi
openaire   +2 more sources

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Frontiers in Cellular Neuroscience, 2016
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller, Heidi R Fuller, Berhan eMandefro, Berhan eMandefro, Sally L Shirran, Andrew R Gross, Anjoscha Samija Kaus, Catherine H Botting, Glenn E Morris, Glenn E Morris, Dhruv eSareen, Dhruv eSareen, Dhruv eSareen   +12 more
doaj   +1 more source

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

Neural Regeneration Research, 2022
Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death ...
Rita F Marques, Kent E Duncan
doaj   +1 more source

Tumor Formation via Loss of a Molecular Motor Protein [PDF]

Current Biology, 2006
Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy.
Mazumdar, Manjari, Lee, Ji-Hyeon, Sengupta, Kundan, Ried, Thomas, Rane, Sushil, Misteli, Tom   +5 more
openaire   +2 more sources

An autonomous molecular transport system using DNAs and motor proteins in molecular communication [PDF]

2007 2nd Bio-Inspired Models of Network, Information and Computing Systems, 2007
This paper describes a molecular transport system in molecular communication that uses the machinery in living cells. The molecular transport system requires: 1) loading of the specified cargo molecules at a loading site (at a sender); 2) transport of the loaded cargoes to an unloading site (to a receiver); and 3) unloading of the transported cargoes ...
S. Hiyama, Y. Moritani, T. Suda, T. Shima, K. Sutoh   +4 more
openaire   +1 more source