Results 21 to 30 of about 392,762 (297)
Frontiers in Microbiology, 2022 The Ton complex is a molecular motor at the inner membrane of Gram-negative bacteria that uses a proton gradient to apply forces on outer membrane (OM) proteins to permit active transport of nutrients into the periplasmic space.
Anna C. Ratliff +2 more
doaj +1 more source
TRIM3 regulates the motility of the kinesin motor protein KIF21B. [PDF]
PLoS ONE, 2013 Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport involves
Dorthe Labonté +7 more
doaj +1 more source
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj +1 more source
Evolution of an ancient protein function involved in organized multicellularity in animals. [PDF]
, 2016 To form and maintain organized tissues, multicellular organisms orient their mitotic spindles relative to neighboring cells. A molecular complex scaffolded by the GK protein-interaction domain (GKPID) mediates spindle orientation in diverse animal taxa ...
Anderson, Douglas P +8 more
core +2 more sources
Surface Passivation for Molecular Motor Protein Assays [PDF]
Biophysical Journal, 2010 In kinesin motiliy assays, it has been shown that the surfaces with which kinesin interacts must be passivated in order to prevent kinesin from denaturing on them. The most popular surface blocker is the casein family of milk proteins. Casein is usually purified to various degrees from bovine milk and has many unknowns associated with it when ...
Maloney, Andy +6 more
openaire +1 more source
A physical model of cell metabolism [PDF]
, 2018 Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate.
Fernandez-de-Cossio-Diaz, Jorge +1 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
doaj +1 more source
Neural Regeneration Research, 2022 Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death ...
Rita F Marques, Kent E Duncan
doaj +1 more source
Engineered Pendrin Protein, an Anion Transporter and Molecular Motor [PDF]
Journal of Biological Chemistry, 2011 Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
Jie, Tang +4 more
openaire +2 more sources
Cooperative effects enhance the transport properties of molecular spider teams [PDF]
, 2013 Molecular spiders are synthetic molecular motors based on DNA nanotechnology. While natural molecular motors have evolved towards very high efficiency, it remains a major challenge to develop efficient designs for man-made molecular motors.
Frey, Erwin +2 more
core +2 more sources