Results 21 to 30 of about 5,860,920 (296)

Techniques for studying protein trafficking and molecular motors in neurons [PDF]

Cytoskeleton, 2016
This review focused on techniques that facilitated the visualization of protein trafficking. In the mid‐1990s the cloning of GFP allowed fluorescently tagged proteins to be expressed in cells and then visualized in real time. This advance allowed a glimpse, for the first time, of the complex system within cells for distributing proteins.
Shanxi, Feng, Don B, Arnold
openaire   +2 more sources

Differential expression of molecular motors in the motor cortex of sporadic ALS

Neurobiology of Disease, 2007
The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood.
Maria Pantelidou, Spyros E. Zographos, Carsten W. Lederer, Theodore Kyriakides, Michael W. Pfaffl, Niovi Santama   +5 more
doaj   +1 more source

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Frontiers in Molecular Biosciences, 2022
Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan   +7 more
doaj   +1 more source

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj   +1 more source

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W., McMahan, U. J., Escher, G., Gensch, Erin M., Tsim, Karl W.K., Escher, Gérard, Kroger, S., Kröger, Stephan, Horton, Sharon E., Ruegg, M. A., Tsim, Karl W. K., Horton, S. E., Gensch, E. M., Ruegg, Markus A.   +13 more
core   +1 more source

TRIM3 regulates the motility of the kinesin motor protein KIF21B. [PDF]

PLoS ONE, 2013
Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport involves
Dorthe Labonté, Edda Thies, Yvonne Pechmann, Alexander J Groffen, Matthijs Verhage, August B Smit, Ronald E van Kesteren, Matthias Kneussel   +7 more
doaj   +1 more source

The Ton Motor

Frontiers in Microbiology, 2022
The Ton complex is a molecular motor at the inner membrane of Gram-negative bacteria that uses a proton gradient to apply forces on outer membrane (OM) proteins to permit active transport of nutrients into the periplasmic space.
Anna C. Ratliff, Susan K. Buchanan, Herve Celia   +2 more
doaj   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Tumor Formation via Loss of a Molecular Motor Protein [PDF]

Current Biology, 2006
Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy.
Mazumdar, Manjari, Lee, Ji-Hyeon, Sengupta, Kundan, Ried, Thomas, Rane, Sushil, Misteli, Tom   +5 more
openaire   +2 more sources

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]

, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L., Federica Catti, David M Warshaw, Nicholas J Westwood, Catti, Federica, Gary E Ward, Jacqueline M Leung, Kimberly L Carey, Leung, Jacqueline M., Warshaw, David M., Ballif, Bryan A., Heaslip, Aoife T., Bryan A Ballif, Westwood, Nicholas J., Ward, Gary E., Aoife T Heaslip, Catti Federica, Leung Jacqueline M., Carey Kimberly L., Warshaw David M., Ballif Bryan A., Westwood Nicholas J., Ward Gary E., Heaslip Aoife T., Westwood, Nicholas J.; id_orcid   +24 more
core   +2 more sources