Results 1 to 10 of about 11,174 (230)

Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons

Cells, 2021
Neurons, regarded as post-mitotic cells, are characterized by their extensive dendritic and axonal arborization. This unique architecture imposes challenges to how to supply materials required at distal neuronal components.
Supriya Swarnkar, Sathyanarayanan Puthanveettil   +1 more
exaly   +4 more sources

Kinesins in Caenorhabditis elegans neuronal morphogenesis [PDF]

Open Biology
Neuronal morphogenesis is regulated by intracellular transport and cytoskeletal dynamics. Kinesin superfamily proteins (KIFs), or kinesins, function as molecular motors for intracellular transport and as regulators of the microtubule cytoskeleton, making
Shinsuke Niwa, Kyoko Chiba
doaj   +3 more sources

Highly Loaded Behavior of Kinesins Increases the Robustness of Transport Under High Resisting Loads

PLoS Computational Biology, 2015
Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads.
Bogdan Epureanu, Woochul Nam
exaly   +4 more sources

Organization of two kinesins in a two-dimensional microtubule network [PDF]

PLoS ONE
In intracellular active transport, molecular motors are responsible for moving biological cargo along networks of microtubules that serve as scaffolds. Cargo dynamics can be modified by different features of microtubule networks such as geometry, density,
Fernando Falo
exaly   +4 more sources

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

PLoS Biology, 2022
Kinesins are microtubule (MT)-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens Plasmodium spp., the causative agents of ...
Sue Vaughan, Rita Tewari, Ravish Rashpa   +2 more
exaly   +2 more sources

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders [PDF]

Current Issues in Molecular Biology
The development and maintenance of the nervous system depend on a tightly regulated intracellular transport network in which kinesin superfamily (KIF) motor proteins drive microtubule-based delivery of synaptic vesicle precursors, organelles, mRNAs, and ...
Mohammad Sadegh Shams Nosrati, Morteza Doustmohammadi, Alireza Dostmohammadi, Armita Kakavand Hamidi, Mahsa Boogari, Zahra Hoseini Tavassol, Shakiba Khosravinejat, Majid Asgari, Morvarid Shafiei, Amir Hesam Nemati, Ferruccio Romano, Valeria Capra, Bruno Sterlini, Mohammad Darbalaei, Mohammad Salehi, Mir Davood Omrani, Federico Zara, Zoha Kibar, Tatsuo Miyamoto, Marcello Scala   +19 more
doaj   +2 more sources

Non-transport functions of motor proteins in corticogenesis [PDF]

Frontiers in Cell and Developmental Biology
Cerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina, Alexandra Medyanik, Victor Tarabykin, Victor Tarabykin, Elena Kondakova, Elena Kondakova   +5 more
doaj   +2 more sources

Investigating the role of Kinesin family in lung adenocarcinoma via integrated bioinformatics approach

Scientific Reports, 2023
Lung cancer is the leading cause of mortality from cancer worldwide. Lung adenocarcinoma (LUAD) is a type of non-small cell lung cancer (NSCLC) with highest prevalence. Kinesins a class of motor proteins are shown to be involved in carcinogenesis.
Gulnaz Tabassum, Prithvi Singh, Rishabh Gurung, Mohammed Ageeli Hakami, Nada Alkhorayef, Ahad Amer Alsaiari, Leena S. Alqahtani, Mohammad Raghibul Hasan, Summya Rashid, Atul Kumar, Kapil Dev, Ravins Dohare   +11 more
doaj   +1 more source

An Unveiled Cell Death Mechanism Exclusive to Human Cancer Cells

Biology and Life Sciences Forum, 2023
The modified phenanthridine PJ34 blocks the post-translational modifications of specific proteins highly expressed in human malignant cells. This exclusively arrests mitosis in human malignant cells by inserting flaws in their mitotic spindle structure ...
Malka Cohen-Armon
doaj   +1 more source

Axonal transport during injury on a theoretical axon

Frontiers in Cellular Neuroscience, 2023
Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles.
Soumyadeep Chandra, Rounak Chatterjee, Zachary T. Olmsted, Zachary T. Olmsted, Amitava Mukherjee, Amitava Mukherjee, Janet L. Paluh   +6 more
doaj   +1 more source