Results 1 to 10 of about 15,656 (252)

Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons

Cells, 2021
Neurons, regarded as post-mitotic cells, are characterized by their extensive dendritic and axonal arborization. This unique architecture imposes challenges to how to supply materials required at distal neuronal components.
Supriya Swarnkar, Sathyanarayanan V Puthanveettil   +1 more
exaly   +3 more sources

Kinesins in Caenorhabditis elegans neuronal morphogenesis [PDF]

Open Biology
Neuronal morphogenesis is regulated by intracellular transport and cytoskeletal dynamics. Kinesin superfamily proteins (KIFs), or kinesins, function as molecular motors for intracellular transport and as regulators of the microtubule cytoskeleton, making
Shinsuke Niwa, Kyoko Chiba
doaj   +2 more sources

Highly Loaded Behavior of Kinesins Increases the Robustness of Transport Under High Resisting Loads

PLoS Computational Biology, 2015
Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads.
Woochul Nam, Bogdan I Epureanu
exaly   +3 more sources

Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes

BMC Genomics, 2006
Background Kinesins, a superfamily of molecular motors, use microtubules as tracks and transport diverse cellular cargoes. All kinesins contain a highly conserved ~350 amino acid motor domain.
Dale N Richardson, Mark P Simmons, Anireddy Sn Reddy   +2 more
exaly   +3 more sources

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

PLoS Biology, 2022
Kinesins are microtubule (MT)-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens Plasmodium spp., the causative agents of ...
Mohammad Zeeshan, Ravish Rashpa, Steven Abel   +2 more
exaly   +2 more sources

Total Internal Reflection Fluorescence (TIRF) Single-Molecule Assay to Analyze the Motility of Kinesin [PDF]

Bio-Protocol
The motile parameters of kinesin superfamily proteins are fundamental to intracellular transport. Single-molecule motility assays using total internal reflection fluorescence (TIRF) microscopy are a gold standard technique for measuring the motile ...
Tomoki Kita, Shinsuke Niwa
doaj   +2 more sources

HPV16 entry requires dynein for minus-end transport and utilizes kinesin Kif11 for plus-end transport along microtubules during mitosis [PDF]

Journal of Virology
Human papillomaviruses (HPVs) travel from the trans-Golgi network (TGN) to the condensed (mitotic) chromosomes during mitosis. Partially uncoated HPV capsids utilize a unique vesicular structure for trafficking and nuclear import, which is directed by ...
Timothy R. Keiffer, Stephen DiGiuseppe, Lucile Guion, Malgorzata Bienkowska-Haba, Katarzyna Zwolinska, Abida Siddiqa, Anand Kushwaha, Martin J. Sapp   +7 more
doaj   +2 more sources

An Unveiled Cell Death Mechanism Exclusive to Human Cancer Cells

Biology and Life Sciences Forum, 2023
The modified phenanthridine PJ34 blocks the post-translational modifications of specific proteins highly expressed in human malignant cells. This exclusively arrests mitosis in human malignant cells by inserting flaws in their mitotic spindle structure ...
Malka Cohen-Armon
doaj   +1 more source

Investigating the role of Kinesin family in lung adenocarcinoma via integrated bioinformatics approach

Scientific Reports, 2023
Lung cancer is the leading cause of mortality from cancer worldwide. Lung adenocarcinoma (LUAD) is a type of non-small cell lung cancer (NSCLC) with highest prevalence. Kinesins a class of motor proteins are shown to be involved in carcinogenesis.
Gulnaz Tabassum, Prithvi Singh, Rishabh Gurung, Mohammed Ageeli Hakami, Nada Alkhorayef, Ahad Amer Alsaiari, Leena S. Alqahtani, Mohammad Raghibul Hasan, Summya Rashid, Atul Kumar, Kapil Dev, Ravins Dohare   +11 more
doaj   +1 more source

Axonal transport during injury on a theoretical axon

Frontiers in Cellular Neuroscience, 2023
Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles.
Soumyadeep Chandra, Rounak Chatterjee, Zachary T. Olmsted, Zachary T. Olmsted, Amitava Mukherjee, Amitava Mukherjee, Janet L. Paluh   +6 more
doaj   +1 more source