Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. [PDF]
PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
doaj +7 more sources
The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
doaj +4 more sources
Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
doaj +2 more sources
Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research? [PDF]
Neurobiology of Disease, 2017 Intracellular trafficking of cargoes is an essential process to maintain the structure and function of all mammalian cell types, but especially of neurons because of their extreme axon/dendrite polarisation.
Kurt J. De Vos, Majid Hafezparast
doaj +3 more sources
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones [PDF]
eLife, 2015 Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP).
Matthias Siebert +19 more
doaj +4 more sources
Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport [PDF]
Frontiers in Molecular NeuroscienceMutations in α-synuclein (α-syn) and LRRK2 cause familial Parkinson’s disease (fPD), yet how these proteins functionally interact remain ambiguous.
Piyali Chakraborty +5 more
doaj +2 more sources
Axonal transport during injury on a theoretical axon. [PDF]
Front Cell Neurosci, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Chandra S +4 more
europepmc +4 more sources
Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
doaj +2 more sources
Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling [PDF]
npj Parkinson's DiseaseThe accumulation of α-synuclein within Lewy bodies is a critical factor in the pathogenesis of Parkinson’s disease, with potential implications for axonal transport deficits.
Xiaoman Yang +8 more
doaj +2 more sources
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport [PDF]
Molecular NeurodegenerationBackground Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide ...
Sen Yang +11 more
doaj +2 more sources