The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
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Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
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Axonal Transport Deficits in Parkinson’s Disease: Insights from Neurotoxin, Genetic, and Sporadic Models [PDF]
Brain SciencesParkinson’s disease (PD) is a prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of Lewy bodies.
Xiaobo Wang, Zhaohui Liu, Wanli W. Smith
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Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
Xin yixue, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
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Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport [PDF]
Frontiers in Molecular NeuroscienceMutations in α-synuclein (α-syn) and LRRK2 cause familial Parkinson’s disease (fPD), yet how these proteins functionally interact remain ambiguous.
Piyali Chakraborty +5 more
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The axonal transport velocity of prions is independent of prion formation. [PDF]
PLoS PathogensPrion diseases are caused by PrPSc, the self-templating infectious conformation of the normal host-encoded prion protein, PrPC. Spread of PrPSc in the peripheral and central nervous system follows a highly predictable pattern consistent with slow axonal ...
Sam M Koshy +6 more
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Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
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Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling [PDF]
npj Parkinson's DiseaseThe accumulation of α-synuclein within Lewy bodies is a critical factor in the pathogenesis of Parkinson’s disease, with potential implications for axonal transport deficits.
Xiaoman Yang +8 more
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Retrograde axonal transport of autophagic vesicles and dynein-dynactin protein interaction are attenuated during aging in the rat optic nerve in vivo [PDF]
Neural Regeneration ResearchAging is characterized by a decreased autophagic activity contributing to the intracellular deposition of damaged organelles and macromolecules. Autophagy is particularly challenging in neurons since autophagic vesicles are formed at the axonal tip and ...
Xiaoyue Luo +6 more
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Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma [PDF]
JCI InsightElevation of intraocular pressure (IOP) due to trabecular meshwork (TM) dysfunction, leading to neurodegeneration, is the pathological hallmark of primary open-angle glaucoma (POAG).
Balasankara Reddy Kaipa +10 more
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