The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
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Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
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Axonal Transport Deficits in Parkinson’s Disease: Insights from Neurotoxin, Genetic, and Sporadic Models [PDF]
Brain SciencesParkinson’s disease (PD) is a prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of Lewy bodies.
Xiaobo Wang, Zhaohui Liu, Wanli W. Smith
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Axonal transport during injury on a theoretical axon. [PDF]
Front Cell Neurosci, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Chandra S +4 more
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Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport [PDF]
Frontiers in Molecular NeuroscienceMutations in α-synuclein (α-syn) and LRRK2 cause familial Parkinson’s disease (fPD), yet how these proteins functionally interact remain ambiguous.
Piyali Chakraborty +5 more
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The Role of Axonal Transport in Glaucoma
International Journal of Molecular Sciences, 2022 Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and leads to progressive vision loss. The first pathological signs can be seen at the optic nerve head (ONH), the structure where RGC axons leave the retina to compose the optic nerve.
Vinicius Ribas +2 more
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Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
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Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling [PDF]
npj Parkinson's DiseaseThe accumulation of α-synuclein within Lewy bodies is a critical factor in the pathogenesis of Parkinson’s disease, with potential implications for axonal transport deficits.
Xiaoman Yang +8 more
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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport [PDF]
Molecular NeurodegenerationBackground Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide ...
Sen Yang +11 more
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Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma [PDF]
JCI InsightElevation of intraocular pressure (IOP) due to trabecular meshwork (TM) dysfunction, leading to neurodegeneration, is the pathological hallmark of primary open-angle glaucoma (POAG).
Balasankara Reddy Kaipa +10 more
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