Results 21 to 30 of about 2,309,945 (284)

Axonal transport during injury on a theoretical axon

Frontiers in Cellular Neuroscience, 2023
Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra, Rounak Chatterjee, Zachary T. Olmsted, Zachary T. Olmsted, Amitava Mukherjee, Amitava Mukherjee, Janet L. Paluh   +6 more
openaire   +3 more sources

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. [PDF]

, 2010
BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal.
Sokoloff Alan J, Miri D Rabinowitz, Munglani, Raj, Filler, Aaron G, Filler, A.G, Munglani, R, Chris Abell, Rabinowitz, Miri D, Terrence W Deacon, Andrew ML Lever, Deacon Terrence W, Munglani Raj, Mark Bacon, Sokoloff, Alan J, Franklyn A Howe, Deacon, T.W, Whiteside, Garth T, Bacon, Mark, Howe, F.A, Abell, Chris, Sokoloff, AJ, Griffiths, J.R, Filler Aaron G, Lever, Andrew ML, Howe, FA, Alan J Sokoloff, Martyn Frederickson, Bell B Anthony, Bell, B.A, Bacon, M, Frederickson Martyn, Garth T Whiteside, Griffiths, John R, Abell, C, Aaron G Filler, B Anthony Bell, Griffiths John R, Rabinowitz Miri D, Bacon Mark, Bell, B Anthony, Lever, A.M.L, Frederickson, Martyn, Filler, AG, Abell Chris, Sokoloff, A.J, Frederickson, M, John R Griffiths, Lever Andrew ML, Whiteside Garth T, Deacon, Terrence W, Bell, BA, Whiteside, GT, Griffiths, JR, Rabinowitz, MD, Deacon, TW, Lever, AM, Whiteside, G.T, Howe Franklyn A, Howe, Franklyn A, Raj Munglani, Rabinowitz, M.D   +60 more
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Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

Neurobiology of Disease, 2015
Parkinson's disease (PD) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. The spread of α-synuclein (α-syn)
Jennifer T. Lamberts, Erin N. Hildebrandt, Patrik Brundin   +2 more
doaj   +1 more source

Ex Vivo Recording of Axonal Transport Dynamics on Postnatal Organotypic Cortical Slices

STAR Protocols, 2020
Summary: Axonal transport is a physiological process adopted by neurons to transport organelles, proteins, and other molecules along their axonal projections.
Silvia Turchetto, Loic Broix, Laurent Nguyen   +2 more
doaj   +1 more source

Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]

PLoS Pathogens, 2018
Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny, Orkide O Koyuncu, Christoph Wirblich, Matthias J Schnell, Lynn W Enquist   +4 more
doaj   +1 more source

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice [PDF]

, 2005
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for
Dairin Kieran, Martin, J, Joanne Martin, Schiavo, G, Giampietro Schiavo (107907), Dick, JRT, Greensmith, L., Joanne Martin (11260388), Bohnert, S, Hafezparast, M., Elizabeth M.C. Fisher, Fisher, EMC, Linda Greensmith, Stephanie Bohnert (16066082), Martin, J., Majid Hafezparast (4461484), Fisher, E.M.C., James R T Dick (16066085), Majid Hafezparast, Greensmith, L, Linda Greensmith (252146), Giampietro Schiavo, Kieran, D., Bohnert, S., Stephanie Bohnert, James R.T. Dick, Dairin Kieran (7953794), Dick, J.R.T., Kieran, D, Hafezparast, M, Schiavo, G., Elizabeth M C Fisher (16062626)   +31 more
core   +1 more source

Traumatic axonal injury in the spinal cord evoked by traumatic brain injury [PDF]

, 2008
Although it is well known that traumatic brain injury (TBI) evokes traumatic axonal injury (TAI) within the brain, TBI-induced axonal damage in the spinal cord (SC) has been less extensively investigated.
Czeiter, Endre,, Dóczi, Tamás, Luckl, Janos,, Doczi, Tamas,, Kovesdi, Erzsebet,, Büki, András, Pál, József, Pal, Jozsef,, Czeiter, Endre, Bukovics, Peter,, Kövesdi, Erzsébet, Lückl, János, Büki, Andras,, Bukovics, Péter   +13 more
core   +1 more source

Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

Cell Reports, 2021
Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund, Matthew Domenic Lycas, Anders Schack, Rita Chan Andersen, Ulrik Gether, Ole Kjaerulff   +5 more
doaj   +1 more source

Dynamics of Mitochondrial Transport in Axons [PDF]

Frontiers in Cellular Neuroscience, 2016
The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only
Niescier, Robert F., Kwak, Sang Kyu, Joo, Se Hun, Chang, Karen T., Min, Kyung-Tai   +4 more
openaire   +4 more sources

Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT

Neurobiology of Disease, 2014
Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration protein (WldS) or related nicotinamide mononucleotide adenyltransferases (NmNATs) protects axons ...
Cheng Fang, Helena Decker, Gary Banker
doaj   +1 more source