Ex Vivo Recording of Axonal Transport Dynamics on Postnatal Organotypic Cortical Slices
STAR Protocols, 2020 Summary: Axonal transport is a physiological process adopted by neurons to transport organelles, proteins, and other molecules along their axonal projections.
Silvia Turchetto +2 more
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Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]
PLoS Pathogens, 2018 Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny +4 more
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Regulation of Axonal Transport by Protein Kinases [PDF]
, 2015 The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic ...
Gibbs, KL, Greensmith, L, Schiavo, G
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Neurobiology of Disease, 2015 Parkinson's disease (PD) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. The spread of α-synuclein (α-syn)
Jennifer T. Lamberts +2 more
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Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Cell Reports, 2021 Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund +5 more
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Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels [PDF]
, 2017 Defective axonal transport is an early neuropathological feature of amyotrophic lateral sclerosis (ALS). We have previously shown that ALS-associated mutations in Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor ...
Bauer, C.S. +4 more
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A Stochastic Compartmental Model for Fast Axonal Transport [PDF]
, 2011 In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A. +2 more
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Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT
Neurobiology of Disease, 2014 Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration protein (WldS) or related nicotinamide mononucleotide adenyltransferases (NmNATs) protects axons ...
Cheng Fang, Helena Decker, Gary Banker
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Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
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Axonal transport defects are a common phenotype in Drosophila models of ALS [PDF]
, 2016 Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons resulting in a catastrophic loss of motor function. Current therapies are severely limited owing to a poor mechanistic understanding of the pathobiology ...
Alexander J. Whitworth +5 more
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