Results 21 to 30 of about 68,124 (256)
Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Cell Reports, 2021 Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund +5 more
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PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
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Dynamics of Mitochondrial Transport in Axons [PDF]
Frontiers in Cellular Neuroscience, 2016 The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only
Niescier, Robert F. +4 more
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Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT
Neurobiology of Disease, 2014 Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration protein (WldS) or related nicotinamide mononucleotide adenyltransferases (NmNATs) protects axons ...
Cheng Fang, Helena Decker, Gary Banker
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Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
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Neurobiology of Disease, 2017 Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal transport, a process in which cellular cargo is shuttled with the aid of molecular motors from the cell body to axonal termini and back along microtubules (MTs).
Kurt R. Brunden +4 more
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CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS Genetics, 2021 Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen +3 more
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Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]
PLoS Pathogens, 2009 Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev +7 more
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Acta Neuropathologica Communications, 2019 Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz +9 more
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Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement
Neurobiology of Disease, 2019 Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang +4 more
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