Axonal transport: Driving synaptic function
Science, 2019 From trafficking to maintenance Neurons are remarkably polarized in that proteins made in the cytosol often need to travel many tens or hundreds of cell body lengths along axons to their sites of action in the synapse. Axonal transport of these components is driven by molecular motors along axonal microtubules. Guedes-Dias and Holzbaur review
Pedro Guedes-Dias, Erika L. F. Holzbaur
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Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma [PDF]
JCI InsightElevation of intraocular pressure (IOP) due to trabecular meshwork (TM) dysfunction, leading to neurodegeneration, is the pathological hallmark of primary open-angle glaucoma (POAG).
Balasankara Reddy Kaipa +10 more
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Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
Xin yixue, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
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HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. [PDF]
PLoS ONE, 2012 Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood.
Chaeyoung Kim +6 more
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Anterograde Axonal Transport in Neuronal Homeostasis and Disease
Frontiers in Molecular Neuroscience, 2020 Neurons are highly polarized cells with an elongated axon that extends far away from the cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of membranous organelles and other molecular complexes.
Laurent Guillaud +3 more
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A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. [PDF]
PLoS ONE, 2017 Improving axonal transport in the injured and diseased central nervous system has been proposed as a promising strategy to improve neuronal repair. However, the contribution of each cargo to the repair mechanism is unknown.
Romain Cartoni +4 more
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
Molecular Neurodegeneration, 2012 Background Reactive oxygen species (ROS) released by microglia and other inflammatory cells can cause axonal degeneration. A reduction in axonal transport has also been implicated as a cause of axonal dystrophies and neurodegeneration, but there is a ...
Fang Cheng +2 more
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Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]
, 2010 It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown +10 more
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Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport
Journal of Pharmacological Sciences, 2010 Axonal transport plays a crucial role in neuronal morphogenesis, survival, and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for axonal ...
Yoshio Goshima +10 more
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Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]
, 2009 Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis +6 more
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