Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. [PDF]
PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
Molecular Neurodegeneration, 2012 Background Reactive oxygen species (ROS) released by microglia and other inflammatory cells can cause axonal degeneration. A reduction in axonal transport has also been implicated as a cause of axonal dystrophies and neurodegeneration, but there is a ...
Fang Cheng +2 more
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Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport
Journal of Pharmacological Sciences, 2010 Axonal transport plays a crucial role in neuronal morphogenesis, survival, and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for axonal ...
Yoshio Goshima +10 more
doaj +2 more sources
Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons [PDF]
Neurobiology of Disease, 2009 Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in the huntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal htt fragments perturb axonal transport in vitro.
C. Sinadinos +6 more
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Live Imaging of Axonal Transport in the Motor Neurons of Drosophila Larvae
Bio-Protocol, 2017 Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as ...
Tsuyoshi Inoshita +2 more
doaj +2 more sources
Role of LRRK2 in axonal transport and Parkinson's disease. [PDF]
Biochem JAxonal transport is crucial for neuronal health and function, facilitating the delivery of newly synthesized material from the soma via anterograde transport and the removal of aged proteins and damaged organelles for degradation via retrograde transport.
Twellsieck B, Boecker CA.
europepmc +2 more sources
HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. [PDF]
PLoS ONE, 2012 Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood.
Chaeyoung Kim +6 more
doaj +1 more source
Anterograde Axonal Transport in Neuronal Homeostasis and Disease
Frontiers in Molecular Neuroscience, 2020 Neurons are highly polarized cells with an elongated axon that extends far away from the cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of membranous organelles and other molecular complexes.
Laurent Guillaud +3 more
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A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. [PDF]
PLoS ONE, 2017 Improving axonal transport in the injured and diseased central nervous system has been proposed as a promising strategy to improve neuronal repair. However, the contribution of each cargo to the repair mechanism is unknown.
Romain Cartoni +4 more
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The axonal transport of mitochondria [PDF]
Journal of Cell Science, 2005 Organelle transport is vital for the development and maintenance of axons, in which the distances between sites of organelle biogenesis, function, and recycling or degradation can be vast. Movement of mitochondria in axons can serve as a general model for how all organelles move: mitochondria are easy to identify, they move along both microtubule and ...
Peter J, Hollenbeck, William M, Saxton
openaire +4 more sources