Results 31 to 40 of about 2,309,945 (284)
Axonal transport defects in retinal Ganglion cell diseases
, 2023 For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss.
Özdemir, Fatma +2 more
core +1 more source
Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
doaj +1 more source
Neurobiology of Disease, 2017 Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal transport, a process in which cellular cargo is shuttled with the aid of molecular motors from the cell body to axonal termini and back along microtubules (MTs).
Kurt R. Brunden +4 more
doaj +1 more source
CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS Genetics, 2021 Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen +3 more
doaj +1 more source
Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]
PLoS Pathogens, 2009 Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev +7 more
doaj +1 more source
Acta Neuropathologica Communications, 2019 Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz +9 more
doaj +1 more source
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement
Neurobiology of Disease, 2019 Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang +4 more
doaj +1 more source
Neurofilaments Are Transported Rapidly But Intermittently in Axons: Implications for Slow Axonal Transport [PDF]
The Journal of Neuroscience, 2000 Slow axonal transport conveys cytoskeletal proteins from cell body to axon tip. This transport provides the axon with the architectural elements that are required to generate and maintain its elongate shape and also generates forces within the axon that are necessary for axon growth and navigation.
S, Roy +5 more
openaire +2 more sources
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
Cell Reports, 2019 Summary: Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria.
Evgeny Shlevkov +15 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui +6 more
doaj +1 more source