Results 31 to 40 of about 124,572 (294)

Waves, rings, and trails: The scenic landscape of axonal actin. [PDF]

, 2016
The goal of this article is to provide the reader a snapshot of recent studies on axonal actin--largely emerging from superresolution and live-imaging experiments--and place this new information in context with earlier ...
Roy, Subhojit
core   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
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Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]

PLoS Pathogens, 2009
Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev, Toni Cathomen, Julia Merk, Mike Friedrich, Wolfgang Härtig, Gregory S Harms, Michael A Klein, Eckhard Flechsig   +7 more
doaj   +1 more source

Traumatic axonal injury in the spinal cord evoked by traumatic brain injury [PDF]

, 2008
Although it is well known that traumatic brain injury (TBI) evokes traumatic axonal injury (TAI) within the brain, TBI-induced axonal damage in the spinal cord (SC) has been less extensively investigated.
Bukovics, Péter, Büki, András, Czeiter, Endre, Dóczi, Tamás, Kövesdi, Erzsébet, Lückl, János, Pál, József   +6 more
core   +1 more source

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

Neurobiology of Disease, 2017
Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal transport, a process in which cellular cargo is shuttled with the aid of molecular motors from the cell body to axonal termini and back along microtubules (MTs).
Kurt R. Brunden, Virginia M-Y. Lee, Amos B. Smith, III, John Q. Trojanowski, Carlo Ballatore   +4 more
doaj   +1 more source

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.

PLoS Genetics, 2021
Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen, Hao-Ru Huang, Chia-Hao Hsu, Chan-Yen Ou   +3 more
doaj   +1 more source

Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement

Neurobiology of Disease, 2019
Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang, Jing Tian, Hao Chen, Heng Du, Lan Guo   +4 more
doaj   +1 more source

Profiling Axonal mRNA Transport [PDF]

, 2011
The importance of mRNA localization and localized protein synthesis to spatially modulate protein levels in distinct subcellular domains has increasingly been recognized in recent years. Axonal and dendritic processes of neurons represent separate functional domains of the cell that have shown the capacity to autonomously respond to extracellular ...
Dianna E, Willis, Jeffery L, Twiss
openaire   +2 more sources

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Acta Neuropathologica Communications, 2019
Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni, Christopher C. J. Miller   +9 more
doaj   +1 more source

Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui, Mitali Biswas, Pramod Rajaram Somvanshi, Preethi Kandagiri, Madhavi Gorla, Fareed Mohammed, Prasad Tammineni   +6 more
doaj   +1 more source