Results 31 to 40 of about 68,124 (256)
Frontiers in Molecular Neuroscience, 2022 Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui +6 more
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A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
Cell Reports, 2019 Summary: Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria.
Evgeny Shlevkov +15 more
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Neurofilaments Are Transported Rapidly But Intermittently in Axons: Implications for Slow Axonal Transport [PDF]
The Journal of Neuroscience, 2000 Slow axonal transport conveys cytoskeletal proteins from cell body to axon tip. This transport provides the axon with the architectural elements that are required to generate and maintain its elongate shape and also generates forces within the axon that are necessary for axon growth and navigation.
S, Roy +5 more
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Effects of α-synuclein on axonal transport
Neurobiology of Disease, 2017 Lewy bodies and Lewy neurites composed primarily of α-synuclein characterize synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB).
Laura A. Volpicelli-Daley
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Unraveling axonal mechanisms of traumatic brain injury
Acta Neuropathologica Communications, 2022 Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current evidence proposes a role of perturbed Ca2+ homeostasis in AS formation, involving impaired axonal transport ...
Victorio M. Pozo Devoto +10 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Acta Neuropathologica Communications, 2019 Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz +8 more
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The evolution of the axonal transport toolkit [PDF]
Traffic, 2019 Abstract Neurons are highly polarized cells that critically depend on long‐range, bidirectional transport between the cell body and synapse for their function. This continual and highly coordinated trafficking process, which takes place via the axon, has fascinated researchers since the early 20th century. Ramon y Cajal first proposed
Sunaina Surana +8 more
openaire +5 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Oligodendrocytes support axonal transport and maintenance via exosome secretion.
PLoS Biology, 2020 Neurons extend long axons that require maintenance and are susceptible to degeneration. Long-term integrity of axons depends on intrinsic mechanisms including axonal transport and extrinsic support from adjacent glial cells.
Carsten Frühbeis +10 more
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