Results 51 to 60 of about 2,309,945 (284)
Neurobiology of Disease, 2013 NAP (davunetide) is a novel neuroprotective compound with mechanism of action that appears to involve microtubule (MT) stabilization and repair. To evaluate, for the first time, the impact of NAP on axonal transport in vivo and to translate it to ...
Yan Jouroukhin +5 more
doaj +1 more source
Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy
Cells, 2020 We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport.
Lucia G. Le Roux +6 more
doaj +1 more source
Axonal transport in dystrophic hamsters
, 1981 Axonal transport of [3H]proline, [3H]fucose, and choline acetyltransferase (CAT) was examined in 20-, 50-, and 100-day-old dystrophic and control hamsters.
P. L. Wood, R. J. Boegman
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
eLife, 2015 Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP).
Matthias Siebert +19 more
doaj +1 more source
Cell Reports, 2020 Summary: BORC is a multisubunit complex previously shown to promote coupling of mammalian lysosomes and C. elegans synaptic vesicle (SV) precursors (SVPs) to kinesins for anterograde transport of these organelles along microtubule tracks. We attempted to
Raffaella De Pace +7 more
doaj +1 more source
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review
Frontiers in Molecular Neuroscience, 2023 Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be
Xiaoman Yang +4 more
doaj +1 more source
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss [PDF]
, 2005 This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration.
Petzold, A
core
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Defects in axonal transport in inherited neuropathies
, 2019 : Axonal transport is a highly complex process essential for sustaining proper neuronal functioning. Disturbances can result in an altered neuronal homeostasis, aggregation of cargoes, and ultimately a dying-back degeneration of neurons.
Sisto, Angela +4 more
core +1 more source