Results 71 to 80 of about 2,309,945 (284)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch +5 more
wiley +1 more source
Profiling Axonal mRNA Transport [PDF]
, 2011 The importance of mRNA localization and localized protein synthesis to spatially modulate protein levels in distinct subcellular domains has increasingly been recognized in recent years. Axonal and dendritic processes of neurons represent separate functional domains of the cell that have shown the capacity to autonomously respond to extracellular ...
Dianna E, Willis, Jeffery L, Twiss
openaire +2 more sources
Mechanism of Fast Axonal Transport Inhibition by Polyglutamine Expanded Huntingtin.
, 2014 Mechanism of Fast Axonal Transport Inhibition by Polyglutamine Expanded ...
Sarah L. Pollema (7973459)
core +2 more sources
Expanding the Toolkit for In Vivo Imaging of Axonal Transport [PDF]
, 2021 Axonal transport maintains neuronal homeostasis by enabling the bidirectional trafficking of diverse organelles and cargoes. Disruptions in axonal transport have devastating consequences for individual neurons and their networks, and contribute to a ...
Tosolini, A +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Frontiers in Cellular NeuroscienceDue to their large scale and uniquely branched architecture, neurons critically rely on active transport of mitochondria in order to match energy production and calcium buffering to local demand.
Tom Venneman, Pieter Vanden Berghe
doaj +1 more source
MODELING TRAFFIC JAMS IN SLOW AXONAL TRANSPORT
, 2010 The purpose of this paper is to develop a model capable of simulating traffic jams in slow axonal transport. Slowing of slow axonal transport is an early sign of some neurodegenerative diseases.
D. G. BLINOV +2 more
core +1 more source
MAPping out distribution routes for kinesin couriers [PDF]
, 2013 In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins.
Moores, Carolyn A. +5 more
core +1 more source
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou +6 more
wiley +1 more source