Results 71 to 80 of about 124,572 (294)

Axonal transport maintains taste responses [PDF]

Brain Research, 1981
Transection of the gerbil's IXth nerve causes gustatory action potentials to decline in 1-6 h; the rate of decline is a linear function of the length of the nerve stump remaining attached to the tongue. To test the implication that taste discharge mechanisms depend upon axonal transport in the IXth nerve, we injected 40 nl of [3H]leucine into the ...
Oakley, Bruce, Chu, Joyce S., Jones, Lee B.   +2 more
openaire   +3 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

Cell Death and Disease, 2022
Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1G93A mice.
Elena R. Rhymes, Andrew P. Tosolini, Alexander D. Fellows, William Mahy, Neil Q. McDonald, Giampietro Schiavo   +5 more
doaj   +1 more source

Mitochondrial behavior when things go wrong in the axon

Frontiers in Cellular Neuroscience, 2022
Axonal homeostasis is maintained by processes that include cytoskeletal regulation, cargo transport, synaptic activity, ionic balance, and energy supply. Several of these processes involve mitochondria to varying degrees.
Victorio M. Pozo Devoto, Isaac G. Onyango, Gorazd B. Stokin, Gorazd B. Stokin, Gorazd B. Stokin   +4 more
doaj   +1 more source

Intracellular transport driven by cytoskeletal motors: General mechanisms and defects

, 2015
Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large.
Appert-Rolland, Cecile, Ebbinghaus, Maximilian, Santen, Ludger   +2 more
core   +3 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Neuronal activity inhibits mitochondrial transport only in synaptically connected segments of the axon

Frontiers in Cellular Neuroscience
Due to their large scale and uniquely branched architecture, neurons critically rely on active transport of mitochondria in order to match energy production and calcium buffering to local demand.
Tom Venneman, Pieter Vanden Berghe
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale [PDF]

, 2009
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is however critical both for basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap,
A MacKenzie-Graham, A Reiner, A Vercelli, A Visel, Allan Jones, AM Hattox, Arthur W. Toga, AW Toga, AY Hardan, B Egaas, B Horwitz, BL Davidson, Brett D. Mensh, Bruce W. Stillman, C Gustafson, C Kobbert, Caizhi Wu, CL Veenman, Claus C. Hilgetag, Clifford B. Saper, CR Gerfen, D Atasoy, DA Benson, Daniel G. Herrera, David C. Van Essen, David Kleinfeld, DC Van Essen, DC Van Essen, DL Sparks, E Miyashita, ED Jarvis, Edward G. Jones, EM Callaway, ES Lein, ET Bullmore, F Castelli, F Crick, G Aston-Jones, H Markram, Hans C. Breiter, Harvey J. Karten, HC Breiter, Helen Barbas, Hemant Bokil, Henry A. Lester, Hollis T. Cline, IR Wickersham, J DeFalco, J Dejerine, J Panksepp, J Panksepp, Jaak Panksepp, James D. Watson, Jason W. Bohland, JD Schmahmann, Jeremy D. Schmahmann, JF Démonet, JG Bjaalie, JG Bjaalie, JG Bjaalie, JG White, JL Lanciego, JM Lin, John C. Doyle, John M. Lin, Joseph L. Price, Joseph Safdieh, K Oishi, K Wernicke, Karel Svoboda, KE Stephan, KE Stephan, L Ng, L Stein, Larry W. Swanson, LM Coolen, M Bota, M Bota, M Bota, M Murias, MA Just, MD Johnson, MI Ekstrand, Michael Hawrylycz, Mihail Bota, MJ Swift, N Geschwind, Nicholas D. Schiff, O Sporns, Olaf Sporns, Partha P. Mitra, Peter J. Freed, PH Luppi, PJ Broser, R Kotter, R Kotter, Ralph J. Greenspan, RH Güting, RM Kelly, Rolf Kötter, RW Baughman, S Folstein, S Lillehaug, S Mikula, Shawn Mikula, Suzanne N. Haber, U Burgel, U Frith, V Grinevich, Z. Josh Huang   +109 more
core   +9 more sources