Results 11 to 20 of about 25,177 (273)
Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends [PDF]
eLife, 2020 Intracellular transport relies on multiple kinesins, but it is poorly understood which kinesins are present on particular cargos, what their contributions are and whether they act simultaneously on the same cargo.
Andrea Serra-Marques +13 more
doaj +3 more sources
Targeting Kinesins for Therapeutic Exploitation of Chromosomal Instability in Lung Cancer. [PDF]
Cancers (Basel)New therapeutic approaches that antagonize tumour-promoting phenotypes in lung cancer are needed to improve patient outcomes. Chromosomal instability (CIN) is a hallmark of lung cancer characterized by the ongoing acquisition of genetic alterations that ...
Zhang C, Wu BZ, Thu KL.
europepmc +3 more sources
Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]
Current Biology, 2014 The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
Hancock, William O.
core +4 more sources
Biochemical Society Transactions, 2015 Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtubule polymer.
Alice, Bachmann, Anne, Straube
core +4 more sources
Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport
Frontiers in Cell and Developmental Biology, 2022 Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions determine the direction, timing and flux of various intracellular transports.
Diksha Kumari, Krishanu Ray
doaj +2 more sources
Kinesins in spermatogenesis† [PDF]
Biology of Reproduction, 2017 Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Dan-Dan, Ma, Da-Hui, Wang, Wan-Xi, Yang
openaire +3 more sources
Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
Cell Death and DiseaseCilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling.
Lin Li, Jie Ran
doaj +2 more sources
Multiple kinesins induce tension for smooth cargo transport
eLife, 2019 How cargoes move within a crowded cell—over long distances and at speeds nearly the same as when moving on unimpeded pathway—has long been mysterious.
Marco Tjioe +7 more
doaj +2 more sources
Kinesins in Mammalian Spermatogenesis and Germ Cell Transport
Frontiers in Cell and Developmental Biology, 2022 In mammalian testes, the apical cytoplasm of each Sertoli cell holds up to several dozens of germ cells, especially spermatids that are transported up and down the seminiferous epithelium. The blood-testis barrier (BTB) established by neighboring Sertoli
Mingxia Yao +5 more
doaj +2 more sources
The developmental biology of kinesins
Developmental Biology, 2021 Kinesins are microtubule-based motor proteins that are well known for their key roles in cell biological processes ranging from cell division, to intracellular transport of mRNAs, proteins, vesicles, and organelles, and microtubule disassembly. Interestingly, many of the ~45 distinct kinesin genes in vertebrate genomes have also been associated with ...
Mia J. Konjikusic +2 more
openaire +3 more sources