Results 31 to 40 of about 25,177 (273)
Kinesin transport: driving kinesin in the neuron [PDF]
Current Biology, 2001 A plethora of cytoplasmic motors contribute to the directed transport of a wide range of cellular organelles and molecules. Recent studies have advanced our understanding of cargo attachment to motor molecules and the regulation of intracellular transport.
Hays, Tom, Li, Min-gang
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An Unveiled Cell Death Mechanism Exclusive to Human Cancer Cells
Biology and Life Sciences Forum, 2023 The modified phenanthridine PJ34 blocks the post-translational modifications of specific proteins highly expressed in human malignant cells. This exclusively arrests mitosis in human malignant cells by inserting flaws in their mitotic spindle structure ...
Malka Cohen-Armon
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Scientific Reports, 2023 Lung cancer is the leading cause of mortality from cancer worldwide. Lung adenocarcinoma (LUAD) is a type of non-small cell lung cancer (NSCLC) with highest prevalence. Kinesins a class of motor proteins are shown to be involved in carcinogenesis.
Gulnaz Tabassum +11 more
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Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles.
Soumyadeep Chandra +6 more
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Journal of Cell Science, 2010 Kinesin was discovered in 1985 – 25 years ago – based on its motility in cytoplasm extruded from the giant axon of the squid ([Allen et al., 1982][1]; [Brady et al., 1982][2]; [Vale et al., 1985][3]).
Endow, Sharyn A +2 more
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Nature, 1996 Chromosome segregation during mitosis depends on the action of the mitotic spindle, a self-organizing, bipolar protein machine which uses microtubules (MTs) and their associated motors. Members of the BimC subfamily of kinesin-related MT-motor proteins are believed to be essential for the formation and functioning of a normal bipolar spindle.
Kashina, A. S +5 more
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Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins
bioRxiv, 2020 Mitotic spindle microtubules (MTs) undergo continuous poleward flux, whose driving force and function in humans remain unclear. Here, we combined loss-of-function screenings with analysis of MT dynamics in human cells to investigate the molecular ...
Yulia Steblyanko +8 more
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Kinesins in the Arabidopsis genome: A comparative analysis among eukaryotes
BMC Genomics, 2001 Background Kinesins constitute a superfamily of microtubule motor proteins that are found in eukaryotic organisms. Members of the kinesin superfamily perform many diverse cellular functions such as transport of vesicles and organelles, spindle formation ...
Day Irene S, Reddy Anireddy SN
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Absence of DEATH kinesin is fatal for Leishmania mexicana amastigotes
Scientific Reports, 2022 Kinesins are motor proteins present in organisms from protists to mammals playing important roles in cell division, intracellular organisation and flagellum formation and maintenance.
Suad Gazi Jaafer Husaine Al Kufi +5 more
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eLife, 2021 During metaphase, chromosome position at the spindle equator is regulated by the forces exerted by kinetochore microtubules and polar ejection forces. However, the role of forces arising from mechanical coupling of sister kinetochore fibers with bridging
Mihaela Jagrić +4 more
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