Results 31 to 40 of about 9,389 (207)
Molecules, 2022 Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (
Alessia Ricci +6 more
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Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species
Cells, 2023 The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
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Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]
Current Biology, 2014 The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
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Kinesin-5 inhibitor resistance is driven by kinesin-12 [PDF]
Journal of Cell Biology, 2016 The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is ...
Sturgill, Emma G. +3 more
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Mechanisms of Polarized Organelle Distribution in Neurons
Frontiers in Cellular Neuroscience, 2016 Neurons are highly polarized cells exhibiting axonal and somatodendritic domains with distinct complements of cytoplasmic organelles. Although some organelles are widely distributed throughout the neuronal cytoplasm, others are segregated to either the ...
Dylan J. Britt +3 more
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Kinesin-14: the roots of reversal
BMC Biology, 2010 Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross Robert A
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A look into kinesin's powerhouse [PDF]
FEBS Letters, 2001 Kinesins are microtubule‐dependent motors that serve a multitude of cellular purposes. The conserved motor domain provides the energy required for these processes. Shortly after the solution of the first kinesin motor domain crystal structures the similarity to myosin and G‐proteins was noted.
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eLife, 2020 Intracellular transport relies on multiple kinesins, but it is poorly understood which kinesins are present on particular cargos, what their contributions are and whether they act simultaneously on the same cargo.
Andrea Serra-Marques +13 more
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Microtubule-regulating kinesins [PDF]
Current Biology, 2013 Kinesins can regulate microtubule dynamics? The conventional function of kinesins, much like a molecular freight train, is to transport cargo by motoring along a microtubule (MT) track. But there exists another class of kinesins whose job relates more to track maintenance than transportation.
Sturgill, Emma G., Ohi, Ryoma
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The developmental biology of kinesins
Developmental Biology, 2021 Kinesins are microtubule-based motor proteins that are well known for their key roles in cell biological processes ranging from cell division, to intracellular transport of mRNAs, proteins, vesicles, and organelles, and microtubule disassembly. Interestingly, many of the ~45 distinct kinesin genes in vertebrate genomes have also been associated with ...
Mia J. Konjikusic +2 more
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