Results 51 to 60 of about 25,177 (273)
BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor
eLife, 2020 Low-density lipoprotein receptor (LDLR) in hepatocytes plays a key role in plasma clearance of circulating LDL and in whole body cholesterol homeostasis.
Chang Zhang +3 more
doaj +1 more source
Immunoprecipitation and mass-spectrometric analysis of kinesins.
, 2022 (A) The number of peptides after immunoprecipitation using GFP-trap beads and their coverage to full length kinesins. (B) Locations of peptides in full-length kinesin proteins. (TIF)
Anthony A. Holder (53358) +11 more
core +1 more source
Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons
Frontiers in Cellular Neuroscience, 2020 Neurons require a well-coordinated intercellular transport system to maintain their normal cellular function and morphology. The kinesin family of proteins (KIFs) fills this role by regulating the transport of a diverse array of cargos in post-mitotic ...
Nadine F. Joseph +5 more
doaj +1 more source
Molecules, 2022 Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (
Alessia Ricci +6 more
doaj +1 more source
Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species
Cells, 2023 The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
doaj +1 more source
Kinesin-5 inhibitor resistance is driven by kinesin-12 [PDF]
Journal of Cell Biology, 2016 The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is ...
Sturgill, Emma G. +3 more
openaire +2 more sources
Mechanisms of Polarized Organelle Distribution in Neurons
Frontiers in Cellular Neuroscience, 2016 Neurons are highly polarized cells exhibiting axonal and somatodendritic domains with distinct complements of cytoplasmic organelles. Although some organelles are widely distributed throughout the neuronal cytoplasm, others are segregated to either the ...
Dylan J. Britt +3 more
doaj +1 more source
Cell Reports, 2016 Summary The multiple functions of lysosomes are critically dependent on their ability to undergo bidirectional movement along microtubules between the center and the periphery of the cell.
Carlos M. A. Guardia +4 more
semanticscholar +1 more source
Ciliary kinesins beyond IFT: Cilium length, disassembly, cargo transport and signalling
Biology of the Cell, 2019 Cilia and flagella are microtubule‐based antenna which are highly conserved among eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key functions during development and tissue homoeostasis.
M. Reilly, Alexandre Benmerah
semanticscholar +1 more source
A look into kinesin's powerhouse [PDF]
FEBS Letters, 2001 Kinesins are microtubule‐dependent motors that serve a multitude of cellular purposes. The conserved motor domain provides the energy required for these processes. Shortly after the solution of the first kinesin motor domain crystal structures the similarity to myosin and G‐proteins was noted.
openaire +2 more sources