Results 71 to 80 of about 25,177 (273)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

High-Resolution Imaging of a Single Gliding Protofilament of Tubulins by HS-AFM

Scientific Reports, 2017
In vitro gliding assay of microtubules (MTs) on kinesins has provided us with valuable biophysical and chemo-mechanical insights of this biomolecular motor system.
Jakia Jannat Keya, Daisuke Inoue, Yuki Suzuki, Toshiya Kozai, Daiki Ishikuro, Noriyuki Kodera, Takayuki Uchihashi, Arif Md. Rashedul Kabir, Masayuki Endo, Kazuki Sada, Akira Kakugo   +10 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Kinesins Modify ERR1-Dependent Transcription Using a Conserved Nuclear Receptor Box Motif

, 2023
Kinesin family motors are microtubule (MT)-stimulated ATPases known best as transporters of cellular cargoes through the cytoplasm, regulators of MT dynamics, organizers of the mitotic spindle, and for insuring equal division of DNA during mitosis ...
Sumit Saha, Geri Kreitzer, Sofia Valbuena-Castor, Aleksandra Alimova, A. M. Pramodh Bandara Seneviratne, Kareena Lashley, Sarah Lidagoster   +6 more
core   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, EarlyView.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase

Journal of Cell Biology, 2017
In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein–protein interactions and posttranslational
Sierra N. Cullati, Lilian Kabeche, A. Kettenbach, S. Gerber   +3 more
semanticscholar   +1 more source

Refinement of the rKLi8.3-Based Serodiagnostic ELISA Allows Detection of Canine Leishmaniosis in Dogs with Low Antibody Titers

Pathogens
The diagnosis of canine leishmaniasis (CanL) still represents a challenge due to the variable clinical manifestations and the large number of asymptomatic dogs.
Henrique C. Teixeira, Giulia P. C. Valle, Rouzbeh Mahdavi, Priscila S. M. Dias, Erick E. de Oliveira, Cristina P. Aira, Daniela Heinz, Andreas Latz, Marta de Lana, Fernanda N. Morgado, Renato Porrozzi, Ulrich Steinhoff   +11 more
doaj   +1 more source

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]

Open Biology, 2016
Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel, Hannah R. Belsham, Alexandra J. Rathbone, Bill Wickstead, Christopher Gell, Claire T. Friel   +5 more
doaj   +1 more source

Spatiotemporal Control of Formation of Dynamic Protein Fiber Assemblies via Photophysical Effects of a Focused Laser Beam

Advanced Science, EarlyView.
Tightly focused laser irradiation can accumulate tubulin proteins at/around the laser focus, which leads to the formation of highly ordered microtubule assemblies. The assemblies can exhibit various dynamic behaviors such as radial motion, bundling, and flagella‐like rotation with motor protein and chemical energy, highlighting as a unique tool for ...
Hiroshi Y. Yoshikawa, Ren Shirata, Takuya Takeshige, Riki Yoshida, Fumika Kiryu, Kei Takano, Shuma Matsumoto, Reiji Kawanami, Natsumi Sawada, Chi‐Shiun Wu, Yang‐Hsin Shih, Hiromasa Niinomi, Takahisa Matsuzaki, Seiichiro Nakabayashi, Tomoaki Matsuura, Teruki Sugiyama, Ryuzo Kawamura   +16 more
wiley   +1 more source

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

eLife, 2017
MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins.
Joseph Atherton, I-Mei Yu, Alexander Cook, Joseph M Muretta, Agnel Joseph, Jennifer Major, Yannick Sourigues, Jeffrey Clause, Maya Topf, Steven S Rosenfeld, Anne Houdusse, Carolyn A Moores   +11 more
doaj   +1 more source