Results 81 to 90 of about 9,389 (207)
Journal of Biomechanical Science and Engineering, 2008 Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA +3 more
doaj +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen
G3: Genes, Genomes, Genetics, 2019 Gram-negative bacterial pathogens inject type III secreted effectors (T3SEs) directly into host cells to promote pathogen fitness by manipulating host cellular processes.
Amy Huei-Yi Lee +16 more
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Journal of the Chinese Chemical Society, EarlyView.The conventional “local activation–global inhibition” (LAGI) models utilize mean‐field averaging inhibition to suppress distant activations. As the inhibition diminishes with distance, LAGI models struggle to achieve robust single‐axis polarity in large systems.
Chin‐Lin Guo, Chiao‐Yu Tseng
wiley +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
Environmental Toxicology, EarlyView.ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo +10 more
wiley +1 more source
Integrative Zoology, EarlyView.A quantum‐enhanced weighted gene co‐expression network analysis framework integrating quantum amplitude amplification is developed to overcome sample size constraints in zoological genomics. This noise‐tolerant analytical strategy enables robust network reconstruction for non‐model species with limited biological replicates.
Seok‐Jin Kang, Hongchul Shin
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang +11 more
wiley +1 more source
In vitro Microtubule Bundling Assay under Physiological Conditions
Bio-Protocol, 2017 Kinesins play a role in organizing the mitotic spindle through the crosslinking of microtubules (MTs), made possible through binding sites at opposite ends of the holoenzyme.
Zach Geisterfer, Gin Tezuka, Li Tao
doaj +1 more source