Results 61 to 70 of about 15,656 (252)
FEBS Open Bio, 2021 Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela +5 more
doaj +1 more source
KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation
Advanced Science, EarlyView.This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho +6 more
wiley +1 more source
Kinesin Light Chains Are Essential for Axonal Transport in Drosophila [PDF]
, 1998 Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood.
Beushausen, Sven +4 more
core +2 more sources
High-Resolution Imaging of a Single Gliding Protofilament of Tubulins by HS-AFM
Scientific Reports, 2017 In vitro gliding assay of microtubules (MTs) on kinesins has provided us with valuable biophysical and chemo-mechanical insights of this biomolecular motor system.
Jakia Jannat Keya +10 more
doaj +1 more source
Dissection of kinesin's processivity. [PDF]
PLoS ONE, 2009 The protein family of kinesins contains processive motor proteins that move stepwise along microtubules. This mechanism requires the precise coupling of the catalytic steps in the two heads, and their precise mechanical coordination.
Sarah Adio +4 more
doaj +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair
Advanced Science, EarlyView.This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar +9 more
wiley +1 more source
PathogensThe diagnosis of canine leishmaniasis (CanL) still represents a challenge due to the variable clinical manifestations and the large number of asymptomatic dogs.
Henrique C. Teixeira +11 more
doaj +1 more source
The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
doaj +1 more source
Oncogenic role of kinesin proteins and targeting kinesin therapy
Cancer Science, 2013 The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor domain. Except for some members, many KIF proteins have adenosine triphosphatase activity and microtubule‐dependent plus‐end motion ability. Kinesins participate in several essential cellular functions, including mitosis, meiosis and the transport of macromolecules.
Xinran, Liu, Hao, Gong, Kun, Huang
openaire +3 more sources