Results 61 to 70 of about 9,389 (207)
Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu +9 more
wiley +1 more source
Oncogenic role of kinesin proteins and targeting kinesin therapy
Cancer Science, 2013 The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor domain. Except for some members, many KIF proteins have adenosine triphosphatase activity and microtubule‐dependent plus‐end motion ability. Kinesins participate in several essential cellular functions, including mitosis, meiosis and the transport of macromolecules.
Xinran, Liu, Hao, Gong, Kun, Huang
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Journal of Cell Science, 2004 Dagenbach, E. M. and Endow, S. A. (2004). A new kinesin tree. J. Cell Sci. 117 , [3-7][1]. The neck analysis entries in Table 1 were not aligned correctly in both the print and online versions of this paper. The corrected [Table 1][2] is shown below. We apologise for any inconvenience caused.
Elise M, Dagenbach, Sharyn A, Endow
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A Universal Protein Ladder for Standardization of Diverse FRET Assays
Advanced Science, EarlyView.Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith +5 more
wiley +1 more source
Phylogenetic analysis of the kinesin superfamily from Physcomitrella
Frontiers in Plant Science, 2012 Kinesins are an ancient superfamily of microtubule dependent motors. They participate in an ex-tensive and diverse list of essential cellular functions, including mitosis, cytokinesis, cell polari-zation, cell elongation, flagellar development, and ...
Zhiyuan eShen +4 more
doaj +1 more source
Dynamics of heterodimeric kinesins and cooperation of kinesins
, 2004 18 pages, 5 ...
Xie, Ping, Dou, Shuo-Xing, Wang, Peng-Ye
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Proceedings of the National Academy of Sciences, 2004 We have identified dimeric kinesin mutants that become stalled on the microtubule after one ATP turnover, unable to bind and hydrolyze ATP at their second site. We have used these mutants to determine the regulatory signal that allows ATP to bind to the forward head, such that processive movement can continue.
Lisa M, Klumpp +2 more
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Cytoskeleton, EarlyView.ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas +5 more
wiley +1 more source
Heterogeneity in kinesin function [PDF]
Traffic, 2017 The kinesin family proteins are often studied as prototypical molecular motors; a deeper understanding of them can illuminate regulation of intracellular transport. It is typically assumed that they function identically. Here we find that this assumption of homogeneous function appears incorrect: variation among motors’ velocities in vivo and in vitro ...
Reddy, Babu J N +10 more
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Cytoskeleton, EarlyView.ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius +6 more
wiley +1 more source