Results 11 to 20 of about 717,772 (297)

Direct observation of motor protein stepping in living cells using MINFLUX. [PDF]

Science, 2023
Deguchi T, Iwanski MK, Schentarra EM, Heidebrecht C, Schmidt L, Heck J, Weihs T, Schnorrenberg S, Hoess P, Liu S, Chevyreva V, Noh KM, Kapitein LC, Ries J.   +13 more
europepmc   +2 more sources

Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy

Journal of Biomechanical Science and Engineering, 2021
The high sensitivity of mammalian hearing is achieved by cochlear amplification. The basis of this amplification is the motility of outer hair cells (OHCs), which are sensory cells in the inner ear.
Michio MURAKOSHI, Hiroshi WADA
doaj   +1 more source

Myosin V executes steps of variable length via structurally constrained diffusion

eLife, 2020
The molecular motor myosin V transports cargo by stepping on actin filaments, executing a random diffusive search for actin binding sites at each step.
David Hathcock, Riina Tehver, Michael Hinczewski, D Thirumalai   +3 more
doaj   +1 more source

Coupling of Two Motor Proteins: a New Motor Can Move Faster [PDF]

, 2005
We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is presented.
Anatoly B. Kolomeisky, D. Bray, Evgeny B. Stukalin, Hubert Phillips, J. Howard, P. W. Finch, P. W. Finch, P. W. Finch, T. T. Perkins   +8 more
core   +1 more source

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong, Gao, Limo, Huang, Bo, Huang, Cao, Shi, Xinglong   +4 more
core   +2 more sources

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Escher, G., Gensch, E. M., Horton, S. E., Kroger, S., McMahan, U. J., Ruegg, M. A., Tsim, K. W.   +6 more
core   +2 more sources

Force Dependence of Velocity and Run Length of Kinesin-1, Kinesin-2 and Kinesin-5 Family Molecular Motors

Molecules, 2019
Kinesin-1, kinesin-2 and kinesin-5 are three families of a superfamily of motor proteins; which can walk processively on microtubule filaments by hydrolyzing ATP. It was experimentally shown that while the three kinesin dimers show similar feature on the
Si-Kao Guo, Wei-Chi Wang, Peng-Ye Wang, Ping Xie   +3 more
doaj   +1 more source

Two- and Three-Dimensional Tracking of MFA2 mRNA Molecules in Mating Yeast

Cells, 2020
Intracellular mRNA transport contributes to the spatio-temporal regulation of mRNA function and localized translation. In the budding yeast, Saccharomyces cerevisiae, asymmetric mRNA transport localizes ~30 specific mRNAs including those encoding ...
Polina Geva, Konstantin Komoshvili, Stella Liberman-Aronov   +2 more
doaj   +1 more source

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]

, 2015
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair, Bakeberg, Belzile, Bergman, Cao, Chacon-Heszele, Chih, Dentler, Dorn, Engel, Ferris, Firestone, Garcia-Gonzalo, Gerdes, Goetz, Goodenough, Goodenough, Hildebrandt, Hogan, Hu, Hunnicutt, Hunnicutt, Hyman, Kim, Kong, Kubo, Lancaster, Lin, Liu, Liu, Malicki, Meng, Milenkovic, Molla-Herman, Mukhopadhyay, Mukhopadhyay, Nachury, Ning, Ocbina, Pasquale, Pazour, Pazour, Pedersen, Pijst, Pijst, Rohatgi, Rohatgi, Rosenbaum, Sang, Shih, Snell, Snell, Snell, Tai, Wang, Wang, Wang, Weise, Wiese, Williams, Wilson, Wood, Wood, Ye   +63 more
core   +3 more sources

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]

, 2017
Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
core   +2 more sources