Results 11 to 20 of about 438,155 (307)

KLC4 shapes axon arbors during development and mediates adult behavior

eLife, 2022
Development of elaborate and polarized neuronal morphology requires precisely regulated transport of cellular cargos by motor proteins such as kinesin-1. Kinesin-1 has numerous cellular cargos which must be delivered to unique neuronal compartments.
Elizabeth M Haynes, Korri H Burnett, Jiaye He, Marcel W Jean-Pierre, Martin Jarzyna, Kevin W Eliceiri, Jan Huisken, Mary C Halloran   +7 more
doaj   +1 more source

Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy

Journal of Biomechanical Science and Engineering, 2021
The high sensitivity of mammalian hearing is achieved by cochlear amplification. The basis of this amplification is the motility of outer hair cells (OHCs), which are sensory cells in the inner ear.
Michio MURAKOSHI, Hiroshi WADA
doaj   +1 more source

Myosin V executes steps of variable length via structurally constrained diffusion

eLife, 2020
The molecular motor myosin V transports cargo by stepping on actin filaments, executing a random diffusive search for actin binding sites at each step.
David Hathcock, Riina Tehver, Michael Hinczewski, D Thirumalai   +3 more
doaj   +1 more source

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA [PDF]

, 2012
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA).
Das, Rita, Maniatis, Tom, Sharma, A, Yan, Biao, Tapia, JC, Gygi, Steve P., Monica A. Carrasco, Shneider, NA, Nishimura, AL, Chen, Shi, Yu, Yong, Sharma, Aarti, Yan, B, Gygi, SP, Christopher E. Shaw, Yamazaki, T, Steve P. Gygi, Siddharthan Chandran, Reed, Robin, Yu, Y, Aarti Sharma, Reed, R, Yong Yu, Rita Das, Das, R, Carrasco, Monica A., Zhai, Bo, Shneider, Neil A., Chen, S, Juan C. Tapia, Tapia, Juan C., Agnes Lumi Nishimura, Lalancette-Hebert, Melanie, Haertlein, TC, Tom Maniatis, Lalancette-Hebert, M, Biao Yan, Carrasco, MA, Neil A. Shneider, Yamazaki, Tomohiro, Nishimura, Agnes Lumi, Sullivan, G, Maniatis, T, Shaw, Christopher E., Shi Chen, Zhai, B, Melanie Lalancette-Hebert, Sullivan, Gareth, Tyler C. Haertlein, Shaw, CE, Chandran, S, Haertlein, Tyler C., Tomohiro Yamazaki, Gareth Sullivan, Robin Reed, Bo Zhai, Chandran, Siddharthan   +56 more
core   +1 more source

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]

, 2016
This work was supported by The RJAH Institute of Orthopaedics, UK (H.F.), The SMA Trust, UK (H.F.), Cedars-Sinai Institutional startup funds (D.S), California Institute for Regenerative Medicine Grant RT-02040 (D.S.), National Center for Advancing ...
Heidi R. Fuller, Andrew R. Gross, Kaus, Anjoscha, Morris, Glen, Sareen, Dhruv, Glenn E. Morris, Fuller, H, Shirran, Sally Lorna, Catherine H. Botting, Shirran, SL, Botting, Catherine Helen, Dhruv Sareen, Mandefro, Berhan, Botting, CH, Gross, AR, Berhan Mandefro, Fuller, Heidi, Sally L. Shirran, Sareen, S, Morris, GE, Anjoscha S. Kaus, Gross, Andrew, Mandefro, B, Kaus, AS   +23 more
core   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Force Dependence of Velocity and Run Length of Kinesin-1, Kinesin-2 and Kinesin-5 Family Molecular Motors

Molecules, 2019
Kinesin-1, kinesin-2 and kinesin-5 are three families of a superfamily of motor proteins; which can walk processively on microtubule filaments by hydrolyzing ATP. It was experimentally shown that while the three kinesin dimers show similar feature on the
Si-Kao Guo, Wei-Chi Wang, Peng-Ye Wang, Ping Xie   +3 more
doaj   +1 more source

Two- and Three-Dimensional Tracking of MFA2 mRNA Molecules in Mating Yeast

Cells, 2020
Intracellular mRNA transport contributes to the spatio-temporal regulation of mRNA function and localized translation. In the budding yeast, Saccharomyces cerevisiae, asymmetric mRNA transport localizes ~30 specific mRNAs including those encoding ...
Polina Geva, Konstantin Komoshvili, Stella Liberman-Aronov   +2 more
doaj   +1 more source

cDNA that encodes active agrin [PDF]

, 1992
Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments,
Kröger, Stephan, Tsim, K. W., McMahan, U. J., Ruegg, M. A., Escher, G., Tsim, Karl W. K., Ruegg, Markus A., Escher, Gérard, Tsim, Karl W.K., Kroger, S.   +9 more
core   +1 more source

Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein

Frontiers in Neuroscience, 2021
Golgi defects including Golgi fragmentation are pathological features of Alzheimer’s disease (AD). As a pathogenic factor in AD, amyloid precursor protein (APP) induces Golgi fragmentation in the soma.
Qianqian Du, Qianqian Du, Jin Chang, Jin Chang, Guo Cheng, Guo Cheng, Yinyin Zhao, Yinyin Zhao, Wei Zhou, Wei Zhou   +9 more
doaj   +1 more source