Results 1 to 10 of about 5,717 (230)
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
eLife, 2020 Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee +8 more
doaj +3 more sources
Consensus nomenclature for dyneins and associated assembly factors
Journal of Cell Biology, 2022 Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility ...
Bryony Braschi +2 more
exaly +5 more sources
N-Terminal Processing and Modification of Ciliary Dyneins
Cells, 2023 Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku +2 more
doaj +2 more sources
<i>Chlamydomonas</i> FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins. [PDF]
Proc Natl Acad Sci U S AYamamoto R., Sahashi Y., Shimo-Kon R., et al. Chlamydomonas FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins.
Yamamoto R +11 more
europepmc +2 more sources
Dyneins Across Eukaryotes: A Comparative Genomic Analysis
Traffic, 2007 Dyneins are large minus-end-directed microtubule motors. Each dynein contains at least one dynein heavy chain (DHC) and a variable number of intermediate chains (IC), light intermediate chains (LIC) and light chains (LC).
Bill Wickstead, Keith Gull
exaly +3 more sources
Clockwise Translocation of Microtubules by Flagellar Inner-Arm Dyneins In Vitro
Biophysical Journal, 2008 Cilia and flagella are equipped with multiple species of dyneins that have diverse motor properties. To assess the properties of various axonemal dyneins of Chlamydomonas, in vitro microtubule translocation by isolated dyneins was examined with and ...
Kenji Kikushima, Ritsu Kamiya
exaly +2 more sources
eLife, 2018 Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi +3 more
doaj +2 more sources
FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang, Xuecheng Li, Junmin Pan
exaly +3 more sources
Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
eLife, 2018 We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski +7 more
doaj +2 more sources
Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins. [PDF]
Mol Biol CellTubulins undergo several kinds of posttranslational modifications (PTMs) including glutamylation and glycylation. The contribution of these PTMs to the motilities of cilia and flagella is still unclear.
Kubo T, Sasaki R, Oda T.
europepmc +2 more sources