Results 1 to 10 of about 5,920 (201)
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins [PDF]
eLife, 2020 Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee +8 more
doaj +2 more sources
Non-transport functions of motor proteins in corticogenesis [PDF]
Frontiers in Cell and Developmental BiologyCerebral cortex development is a tightly coordinated sequence of interconnected processes: proliferation of neural progenitors, neuronal migration, neurite differentiation, axonal pathfinding, and synaptogenesis.
Natalia Mitina +5 more
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FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Junmin Pan, Limei Wang, Xuecheng Li
exaly +3 more sources
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein
Scientific Reports, 2022 Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi +2 more
doaj +1 more source
Predicting the locations of force-generating dyneins in beating cilia and flagella
Frontiers in Cell and Developmental Biology, 2022 Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard +7 more
doaj +1 more source
The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa +3 more
doaj +1 more source
Ciliary Dyneins and Dynein Related Ciliopathies
Cells, 2021 Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in ...
Dinu Antony +2 more
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Dynein-Inspired Multilane Exclusion Process with Open Boundary Conditions
Entropy, 2021 Motivated by the sidewise motions of dynein motors shown in experiments, we use a variant of the exclusion process to model the multistep dynamics of dyneins on a cylinder with open ends.
Riya Nandi, Uwe C. Täuber, Priyanka
doaj +1 more source
The World Journal of Men's Health, 2022 The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella.
Bao-Jun Zhuang +10 more
doaj +1 more source