Results 1 to 10 of about 9,153 (135)

A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis [PDF]

Nature Communications
Axoneme assembly constitutes a pivotal process in male gametogenesis of Plasmodium. Plasmodium possesses a unique nuclear envelope-anchored basal body that templates axoneme assembly, distinct from the basal body that templates the axoneme of cilia or ...
Shuzhen Yang, Shanshan Ma, Chengxian Yuan, Zhixun Li, Fanbiao Ji, Luming Yao, Huiting Cui, Qiang Guo, Jing Yuan   +8 more
doaj   +2 more sources

ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility [PDF]

eLife
Sperm motility is essential for male fertility and depends on the structural integrity of the sperm axoneme, which features a canonical ‘9 + 2’ microtubule arrangement.
Shuntai Yu, Guoliang Yin, Peng Jin, Weilin Zhang, Yingchao Tian, Xiaotong Xu, Tianyu Shao, Yushan Li, Fei Sun, Yun Zhu, Fengchao Wang   +10 more
doaj   +2 more sources

Correction: Divergent Plasmodium kinases drive MTOC, kinetochore, and axoneme organisation in male gametogenesis [PDF]

Life Science Alliance
This study reveals how Plasmodium kinases regulate MTOC, axoneme and kinetochore organisation in male gametogenesis, providing key insights into potential targets for malaria transmission control.
Ryuji Yanase, Mohammad Zeeshan, David JP Ferguson, Robert Markus, Declan Brady, Andrew R Bottrill, Anthony A Holder, David S Guttery, Rita Tewari   +8 more
doaj   +2 more sources

Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect [PDF]

Frontiers in Molecular Biosciences
IntroductionPrimary ciliary dyskinesia (PCD) is a genetic disorder affecting motile cilia across various organs, leading to recurrent respiratory infections, subfertility, and laterality defects.
Charlotte de Ceuninck van Capelle, Charlotte de Ceuninck van Capelle, Leo Luo, Leo Luo, Alexander Leitner, Stefan A. Tschanz, Philipp Latzin, Sebastian Ott, Sebastian Ott, Tobias Herren, Loretta Müller, Loretta Müller, Takashi Ishikawa, Takashi Ishikawa   +13 more
doaj   +2 more sources

Predicting the locations of force-generating dyneins in beating cilia and flagella

Frontiers in Cell and Developmental Biology, 2022
Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard, Jonathon Howard, Jonathon Howard, Jonathon Howard, Alexander Chasteen, Xiaoyi Ouyang, Veikko F. Geyer, Pablo Sartori   +7 more
doaj   +1 more source

Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells

Cell Discovery, 2021
Eukaryotic flagella (synonymous with cilia) rely on a microtubule-based axoneme, together with accessory filaments to carryout motility and signaling functions. While axoneme structures are well characterized, 3D ultrastructure of accessory filaments and
Jiayan Zhang, Hui Wang, Simon Imhof, Xueting Zhou, Shiqing Liao, Ivo Atanasov, Wong H. Hui, Kent L. Hill, Z. Hong Zhou   +8 more
doaj   +1 more source

Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

eLife, 2021
We demonstrate a technique for investigating the energetics of flagella or cilia. We record the planar beating of tethered mouse sperm at high resolution. Beating waveforms are reconstructed using proper orthogonal decomposition of the centerline tangent-
Ashwin Nandagiri, Avinash Satish Gaikwad, David L Potter, Reza Nosrati, Julio Soria, Moira K O'Bryan, Sameer Jadhav, Ranganathan Prabhakar   +7 more
doaj   +1 more source

The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo

Cells, 2022
Sperm-associated antigen 6 (SPAG6) is the mammalian orthologue of Chlamydomonas PF16, an axonemal central pair protein involved in flagellar motility. In mice, two Spag6 genes have been identified.
Yi Tian Yap, Wei Li, Qi Zhou, Sarah Haj-Diab, Dipanwita Dutta Chowdhury, Asmita Vaishnav, Pamela Harding, David C. Williams, Brian F. Edwards, Jerome F. Strauss, Zhibing Zhang   +10 more
doaj   +1 more source

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

eLife, 2023
Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in ...
Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa   +2 more
doaj   +1 more source

Progressive Photoreceptor Dysfunction and Age-Related Macular Degeneration-Like Features in rp1l1 Mutant Zebrafish

Cells, 2020
Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Pathogenic mutations in RP1L1 lead to photoreceptor degenerations such as occult macular dystrophy and retinitis pigmentosa.
Nicole C. L. Noel, Nathan J. Nadolski, Jennifer C. Hocking, Ian M. MacDonald, W. Ted Allison   +4 more
doaj   +1 more source