A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis [PDF]
Nature CommunicationsAxoneme assembly constitutes a pivotal process in male gametogenesis of Plasmodium. Plasmodium possesses a unique nuclear envelope-anchored basal body that templates axoneme assembly, distinct from the basal body that templates the axoneme of cilia or ...
Shuzhen Yang +8 more
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ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility [PDF]
eLifeSperm motility is essential for male fertility and depends on the structural integrity of the sperm axoneme, which features a canonical ‘9 + 2’ microtubule arrangement.
Shuntai Yu +10 more
doaj +2 more sources
Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella [PDF]
eLife, 2016 Cilia and flagella are model systems for studying how mechanical forces control morphology. The periodic bending motion of cilia and flagella is thought to arise from mechanical feedback: dynein motors generate sliding forces that bend the flagellum, and
Pablo Sartori +4 more
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Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency [PDF]
Nature CommunicationsThe 9 + 2 microtubule-based axoneme within motile flagella is well known for its symmetry. However, examples of asymmetric structures and proteins asymmetrically positioned within the 9 + 2 axoneme architecture have been identified.
Cecile Fort +3 more
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Correction: Divergent Plasmodium kinases drive MTOC, kinetochore, and axoneme organisation in male gametogenesis [PDF]
Life Science AllianceThis study reveals how Plasmodium kinases regulate MTOC, axoneme and kinetochore organisation in male gametogenesis, providing key insights into potential targets for malaria transmission control.
Ryuji Yanase +8 more
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Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect [PDF]
Frontiers in Molecular BiosciencesIntroductionPrimary ciliary dyskinesia (PCD) is a genetic disorder affecting motile cilia across various organs, leading to recurrent respiratory infections, subfertility, and laterality defects.
Charlotte de Ceuninck van Capelle +13 more
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Predicting the locations of force-generating dyneins in beating cilia and flagella
Frontiers in Cell and Developmental Biology, 2022 Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard +7 more
doaj +1 more source
Cell Discovery, 2021 Eukaryotic flagella (synonymous with cilia) rely on a microtubule-based axoneme, together with accessory filaments to carryout motility and signaling functions. While axoneme structures are well characterized, 3D ultrastructure of accessory filaments and
Jiayan Zhang +8 more
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Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm
eLife, 2021 We demonstrate a technique for investigating the energetics of flagella or cilia. We record the planar beating of tethered mouse sperm at high resolution. Beating waveforms are reconstructed using proper orthogonal decomposition of the centerline tangent-
Ashwin Nandagiri +7 more
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Cells, 2022 Sperm-associated antigen 6 (SPAG6) is the mammalian orthologue of Chlamydomonas PF16, an axonemal central pair protein involved in flagellar motility. In mice, two Spag6 genes have been identified.
Yi Tian Yap +10 more
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