Results 41 to 50 of about 16,625 (265)

A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]

, 2011
The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ, Miss Nicola, Smyllie, Palmer, KJ, Stephens, DJ   +3 more
core   +2 more sources

Parasite motility is critical for virulence of African trypanosomes. [PDF]

, 2018
African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie, Hill, Kent L, Kisalu, Neville, Ozcan, Aydogan, Ray, Sunayan S, Shimogawa, Michelle M, Zhang, Yibo   +6 more
core   +1 more source

Cytoplasmic factories for axonemal dynein assembly [PDF]

Journal of Cell Science, 2021
ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required for the dynein assembly process, and, in mammals, defects lead
openaire   +2 more sources

Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

eLife, 2019
The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include ...
Simon Imhof, Jiayan Zhang, Hui Wang, Khanh Huy Bui, Hoangkim Nguyen, Ivo Atanasov, Wong H Hui, Shun Kai Yang, Z Hong Zhou, Kent L Hill   +9 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

Microtubular Dysfunction and Male Infertility

The World Journal of Men's Health, 2020
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also,
Sezgin Gunes, Pallav Sengupta, Ralf Henkel, Aabed Alguraigari, Mariana Marques Sinigaglia, Malik Kayal, Ahmad Joumah, Ashok Agarwal   +7 more
doaj   +1 more source

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

eLife, 2014
Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear.
Hiroaki Ishikawa, Takahiro Ide, Toshiki Yagi, Xue Jiang, Masafumi Hirono, Hiroyuki Sasaki, Haruaki Yanagisawa, Kimberly A Wemmer, Didier YR Stainier, Hongmin Qin, Ritsu Kamiya, Wallace F Marshall   +11 more
doaj   +1 more source

Life-Saver or Undertaker: The Relationship between Primary Cilia and Cell Death in Vertebrate Embryonic Development

Journal of Developmental Biology, 2022
The development of multicellular organisms requires a tightly coordinated network of cellular processes and intercellular signalling. For more than 20 years, it has been known that primary cilia are deeply involved in the mediation of intercellular ...
Thorsten Pfirrmann, Christoph Gerhardt
doaj   +1 more source

Boarder control on the IFT train

eLife, 2014
New details are revealed about the system that transports proteins to the tip of flagella during growth.
Cécile Fort, Philippe Bastin
doaj   +1 more source

IC2 participates in the cooperative activation of outer arm dynein densely attached to microtubules

Cell Structure and Function, 2023
Ciliary outer-arm dynein (OAD) consists of heavy chains (HCs), intermediate chains (ICs), and light chains (LCs), of which HCs are the motor proteins that produce force.
Yusuke Kondo, Tomoka Ogawa, Emiri Kanno, Masafumi Hirono, Takako Kato-Minoura, Ritsu Kamiya, Toshiki Yagi   +6 more
doaj   +1 more source