Results 31 to 40 of about 11,189 (226)

Mechanisms of Regulation in Intraflagellar Transport

open access: yesCells, 2022
Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia act as antennae to sense a cell’s environment and are involved in a wide range of signaling pathways essential for development. Motile cilia drive cell locomotion
Wouter Mul   +2 more
doaj   +1 more source

Axonemal Dynein Arms [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2016
Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes convert the chemical energy released from adenosine triphosphate (ATP) hydrolysis into mechanical work by causing the doublets to slide with respect to each other.
openaire   +2 more sources

Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia

open access: yesCells, 2022
Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2 ...
Marta Bicka   +6 more
doaj   +1 more source

Cilium axoneme internalization and degradation in chytrid fungi [PDF]

open access: yes, 2020
Loss of the cilium is important for cell cycle progression and certain developmental transitions. Chytrid fungi are a group of basal fungi that have retained centrioles and cilia, and they can disassemble their cilia via axoneme internalization as part ...
Tim Stearns   +5 more
core   +1 more source

Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

open access: yeseLife, 2019
The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include ...
Simon Imhof   +9 more
doaj   +1 more source

Microtubular Dysfunction and Male Infertility

open access: yesThe World Journal of Men's Health, 2020
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also,
Sezgin Gunes   +7 more
doaj   +1 more source

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

open access: yeseLife, 2014
Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear.
Hiroaki Ishikawa   +11 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

open access: yesBiophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi   +3 more
doaj   +1 more source

Boarder control on the IFT train

open access: yeseLife, 2014
New details are revealed about the system that transports proteins to the tip of flagella during growth.
Cécile Fort, Philippe Bastin
doaj   +1 more source

Life-Saver or Undertaker: The Relationship between Primary Cilia and Cell Death in Vertebrate Embryonic Development

open access: yesJournal of Developmental Biology, 2022
The development of multicellular organisms requires a tightly coordinated network of cellular processes and intercellular signalling. For more than 20 years, it has been known that primary cilia are deeply involved in the mediation of intercellular ...
Thorsten Pfirrmann, Christoph Gerhardt
doaj   +1 more source

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