Results 11 to 20 of about 11,189 (226)

A novel role of centrin in flagellar motility: stabilizing an inner-arm dynein motor in the flagellar axoneme

Microbial Cell, 2014
Centrin is an evolutionarily conserved EF-hand calcium-binding protein found in the centriole of animals and the basal body of flagellated organisms. It was originally discovered in the flagellated unicellular green alga Chlamydomonas reinhardtii, where ...
Ziyin Li
doaj   +2 more sources

Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency [PDF]

Nature Communications
The 9 + 2 microtubule-based axoneme within motile flagella is well known for its symmetry. However, examples of asymmetric structures and proteins asymmetrically positioned within the 9 + 2 axoneme architecture have been identified.
Cecile Fort, Benjamin J. Walker, Lore Baert, Richard J. Wheeler   +3 more
doaj   +4 more sources

Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility.

PLoS Genetics, 2020
The flagellum is essential for sperm motility and fertilization in vivo. The axoneme is the main component of the flagella, extending through its entire length.
Seiya Oura, Samina Kazi, Audrey Savolainen, Kaori Nozawa, Julio Castañeda, Zhifeng Yu, Haruhiko Miyata, Ryan M Matzuk, Jan N Hansen, Dagmar Wachten, Martin M Matzuk, Renata Prunskaite-Hyyryläinen   +11 more
doaj   +2 more sources

CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

eLife
The structural integrity of the sperm is crucial for male fertility, defects in sperm head-tail linkage and flagellar axoneme are associated with acephalic spermatozoa syndrome (ASS) and the multiple morphological abnormalities of the sperm flagella ...
Bingbing Wu, Chenghong Long, Yuzhuo Yang, Zhe Zhang, Shuang Ma, Yanjie Ma, Huafang Wei, Jinghe Li, Hui Jiang, Wei Li, Chao Liu   +10 more
doaj   +2 more sources

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice. [PDF]

Andrology
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Wang H, Pham AH, Luo M, Ikawa M, Miyata H.   +4 more
europepmc   +2 more sources

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

eLife, 2023
Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in ...
Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa   +2 more
doaj   +1 more source

Progressive Photoreceptor Dysfunction and Age-Related Macular Degeneration-Like Features in rp1l1 Mutant Zebrafish

Cells, 2020
Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Pathogenic mutations in RP1L1 lead to photoreceptor degenerations such as occult macular dystrophy and retinitis pigmentosa.
Nicole C. L. Noel, Nathan J. Nadolski, Jennifer C. Hocking, Ian M. MacDonald, W. Ted Allison   +4 more
doaj   +1 more source

Axonemal Growth and Alignment During Paraspermatogenesis in the Marine Gastropod Strombus luhuanus

Frontiers in Cell and Developmental Biology, 2022
Parasperm are non-fertilizing sperm that are produced simultaneously with fertile eusperm. They occur in several animal species and show considerable morphological diversity.
Daisuke Shibata, Masaya Morita, Yu Sato, Kogiku Shiba, Seiya Kitanobo, Ryo Yokoya, Kazuo Inaba   +6 more
doaj   +1 more source

Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.

PLoS Genetics, 2020
Approximately 2-15% of couples experience infertility, and around half of these cases are attributed to male infertility. We previously identified TBC1D21 as a sterility-related RabGAP gene derived from infertile men.
Ya-Yun Wang, Chih-Chun Ke, Yen-Lin Chen, Yu-Hua Lin, I-Shing Yu, Wei-Chi Ku, Moira K O'Bryan, Ying-Hung Lin   +7 more
doaj   +1 more source

Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice

Cells, 2023
The axoneme and accessory structures of flagella are critical for sperm motility and male fertilization. Sperm production needs precise and highly ordered gene expression to initiate and sustain the many cellular processes that result in mature ...
Xiuqing He, Wenyu Mu, Ziqi Wang, Ke Xu, Yingying Yin, Gang Lu, Wai-Yee Chan, Hongbin Liu, Yue Lv, Shangming Liu   +9 more
doaj   +1 more source