Results 11 to 20 of about 9,203 (183)
PLoS Genetics, 2020 Approximately 2-15% of couples experience infertility, and around half of these cases are attributed to male infertility. We previously identified TBC1D21 as a sterility-related RabGAP gene derived from infertile men.
Ya-Yun Wang +7 more
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Axonemal Growth and Alignment During Paraspermatogenesis in the Marine Gastropod Strombus luhuanus
Frontiers in Cell and Developmental Biology, 2022 Parasperm are non-fertilizing sperm that are produced simultaneously with fertile eusperm. They occur in several animal species and show considerable morphological diversity.
Daisuke Shibata +6 more
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Cells, 2023 The axoneme and accessory structures of flagella are critical for sperm motility and male fertilization. Sperm production needs precise and highly ordered gene expression to initiate and sustain the many cellular processes that result in mature ...
Xiuqing He +9 more
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Structure of a microtubule-bound axonemal dynein [PDF]
Nature Communications, 2021 Abstract Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localization and ...
Travis Walton, Hao Wu, Alan Brown
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Frontiers in Genetics, 2023 Primary ciliary dyskinesia (PCD) is an inherited autosomal-recessive disorder characterized by abnormal ciliary motion, due to a defect in ciliary structure and/or function. This genetic condition leads to recurrent upper and lower respiratory infections,
Francesca Paola Luongo +12 more
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A Synthetic Minimal Beating Axoneme
Small, 2022 AbstractCilia and flagella are beating rod‐like organelles that enable the directional movement of microorganisms in fluids and fluid transport along the surface of biological organisms or inside organs. The molecular motor axonemal dynein drives their beating by interacting with microtubules. Constructing synthetic beating systems with axonemal dynein
Isabella Guido +7 more
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CRISPs Function to Boost Sperm Power Output and Motility
Frontiers in Cell and Developmental Biology, 2021 Fertilization requires sperm to travel long distances through the complex environment of the female reproductive tract. Despite the strong association between poor motility and infertility, the kinetics of sperm tail movement and the role individual ...
Avinash S. Gaikwad +11 more
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Primary Cilia and Atherosclerosis
Frontiers in Physiology, 2021 In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed
Zhi-Mei Wang +3 more
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Microbial Cell, 2014 Centrin is an evolutionarily conserved EF-hand calcium-binding protein found in the centriole of animals and the basal body of flagellated organisms. It was originally discovered in the flagellated unicellular green alga Chlamydomonas reinhardtii, where ...
Ziyin Li
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N-Terminal Processing and Modification of Ciliary Dyneins
Cells, 2023 Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku +2 more
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