Results 21 to 30 of about 11,189 (226)

Structure of a microtubule-bound axonemal dynein [PDF]

Nature Communications, 2021
Abstract Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localization and ...
Travis Walton, Hao Wu, Alan Brown
openaire   +3 more sources

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm. [PDF]

, 2013
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic respiratory symptoms ...
Danke-Roelse, JE, Hart, S.L., Munye, Mustafa M., Scambler, PJ, Rosser, E.M., Hart, Stephen L, Beales, Philip L, Bacchelli, C, Moore, Anthony T., Chung, Eddie MK, Sloper, John J, Danke-Roelse, Jeannette E, Moore, A.T., Pals, Gerard, Beales, Philip L., Sloper, John J., Moore, Anthony T, Hogg, C, Hogg, C., Bacchelli, Chiara, Mitchison, Hannah M, Shoemark, A., Moore, AT, James, C.T., Scambler, Peter J, Chung, E.M.K., Rosser, Elisabeth M., Bacchelli, C., Shoemark, Amelia; id_orcid, Patel, M., Hogg, Claire, Onoufriadis, Alexandros, Schmidts, Miriam, Emes, R.D., Munye, Mustafa M, Hull, S., Sloper, JJ, Hull, Sarah, Beales, PL, Beales, P.L., Hart, Stephen L., Munye, MM, Schmidts, M, James, Chela T, Scambler, P.J., James, Chela T., Mitchison, H.M., nke-Roelse, J.E., Hull, S, Onoufriadis, A., Rosser, Elisabeth M, Emes, Richard D., Patel, Mitali, Pals, G., Mitchison, Hannah M., Patel, M, Pals, G, Emes, RD, Munye, M.M., James, CT, Schmidts, M., Danke-Roelse, Jeannette E., Chung, Eddie M.K., Shoemark, Amelia, Mitchison, HM, Emes, Richard D, Chung, EM, Shoemark, A, Onoufriadis, A, Sloper, J.J., Hart, SL, Rosser, EM, Scambler, Peter J.   +72 more
core   +1 more source

Case report: The CCDC103 variant causes ultrastructural sperm axonemal defects and total sperm immotility in a professional athlete without primary ciliary diskinesia

Frontiers in Genetics, 2023
Primary ciliary dyskinesia (PCD) is an inherited autosomal-recessive disorder characterized by abnormal ciliary motion, due to a defect in ciliary structure and/or function. This genetic condition leads to recurrent upper and lower respiratory infections,
Francesca Paola Luongo, Alice Luddi, Rosetta Ponchia, Rossella Ferrante, Sara Di Rado, Eugenio Paccagnini, Mariangela Gentile, Pietro Lupetti, Raffaella Guazzo, Alfredo Orrico, Liborio Stuppia, Paola Piomboni, Paola Piomboni   +12 more
doaj   +1 more source

CRISPs Function to Boost Sperm Power Output and Motility

Frontiers in Cell and Developmental Biology, 2021
Fertilization requires sperm to travel long distances through the complex environment of the female reproductive tract. Despite the strong association between poor motility and infertility, the kinetics of sperm tail movement and the role individual ...
Avinash S. Gaikwad, Avinash S. Gaikwad, Ashwin Nandagiri, Ashwin Nandagiri, David L. Potter, Reza Nosrati, Anne E. O’Connor, Anne E. O’Connor, Sameer Jadhav, Julio Soria, Ranganathan Prabhakar, Moira K. O’Bryan   +11 more
doaj   +1 more source

A Synthetic Minimal Beating Axoneme

Small, 2022
AbstractCilia and flagella are beating rod‐like organelles that enable the directional movement of microorganisms in fluids and fluid transport along the surface of biological organisms or inside organs. The molecular motor axonemal dynein drives their beating by interacting with microtubules. Constructing synthetic beating systems with axonemal dynein
Isabella Guido, Andrej Vilfan, Kenta Ishibashi, Hitoshi Sakakibara, Misaki Shiraga, Eberhard Bodenschatz, Ramin Golestanian, Kazuhiro Oiwa   +7 more
openaire   +5 more sources

Primary Cilia and Atherosclerosis

Frontiers in Physiology, 2021
In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed
Zhi-Mei Wang, Xiao-Fei Gao, Jun-Jie Zhang, Shao-Liang Chen   +3 more
doaj   +1 more source

N-Terminal Processing and Modification of Ciliary Dyneins

Cells, 2023
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King   +2 more
doaj   +1 more source

Role of the microtubules in the electrical activity of the primary cilium of renal epithelial cells

Frontiers in Molecular Biosciences, 2023
The primary cilium is a non-motile sensory organelle that transduces environmental cues into cellular responses. It comprises an axoneme, a core of nine doublet microtubules (MTs) coated by a specialized membrane populated by receptors, and a high ...
Noelia Scarinci, Brenda C. Gutierrez, Virginia H. Albarracín, María del Rocío Cantero, Horacio F. Cantiello   +4 more
doaj   +1 more source

Chlamydomonas Basal Bodies as Flagella Organizing Centers

Cells, 2018
During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme.
Jenna Lynne Wingfield, Karl-Ferdinand Lechtreck   +1 more
doaj   +1 more source

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

eLife, 2019
Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey, Shaoda He, Sjors HW Scheres, Andrew P Carter   +3 more
doaj   +1 more source