Results 21 to 30 of about 9,203 (183)
Chlamydomonas Basal Bodies as Flagella Organizing Centers
Cells, 2018 During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme.
Jenna Lynne Wingfield +1 more
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Role of the microtubules in the electrical activity of the primary cilium of renal epithelial cells
Frontiers in Molecular Biosciences, 2023 The primary cilium is a non-motile sensory organelle that transduces environmental cues into cellular responses. It comprises an axoneme, a core of nine doublet microtubules (MTs) coated by a specialized membrane populated by receptors, and a high ...
Noelia Scarinci +4 more
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Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
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Cold Spring Harbor Perspectives in Biology, 2016 Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes convert the chemical energy released from adenosine triphosphate (ATP) hydrolysis into mechanical work by causing the doublets to slide with respect to each other.
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Mechanisms of Regulation in Intraflagellar Transport
Cells, 2022 Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia act as antennae to sense a cell’s environment and are involved in a wide range of signaling pathways essential for development. Motile cilia drive cell locomotion
Wouter Mul +2 more
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Cells, 2022 Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2 ...
Marta Bicka +6 more
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Microtubular Dysfunction and Male Infertility
The World Journal of Men's Health, 2020 Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also,
Sezgin Gunes +7 more
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eLife, 2019 The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include ...
Simon Imhof +9 more
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eLife, 2014 Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear.
Hiroaki Ishikawa +11 more
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Biophysics and Physicobiology, 2023 Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi +3 more
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