Results 1 to 10 of about 1,942 (177)

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins [PDF]

eLife, 2020
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee, Rachael M Cox, Ophelia Papoulas, Amjad Horani, Kevin Drew, Caitlin C Devitt, Steven L Brody, Edward M Marcotte, John B Wallingford   +8 more
doaj   +4 more sources

FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex [PDF]

PLoS Genetics, 2022
Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang, Xuecheng Li, Junmin Pan
exaly   +4 more sources

Structure of a microtubule-bound axonemal dynein [PDF]

Nature Communications, 2021
Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
doaj   +3 more sources

Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. [PDF]

Sci Rep, 2015
Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear.
Karak S, Jacobs JS, Kittelmann M, Spalthoff C, Katana R, Sivan-Loukianova E, Schon MA, Kernan MJ, Eberl DF, Göpfert MC.   +9 more
europepmc   +2 more sources

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

eLife, 2018
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda   +3 more
doaj   +2 more sources

Axonemal dyneins

Current Opinion in Cell Biology, 2008
Recent advances in our understanding of the axonemal dyneins reveal them to be much more complex than previously believed. A combination of genetic, molecular genetic, ultrastructural and biochemical approaches is now aiding the elucidation of the ...
Witman, George B.
core   +4 more sources

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS Genetics, 2020
Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide, Wang Kyaw Twan, Hao Lu, Yayoi Ikawa, Lin-Xenia Lim, Nicole Henninger, Hiromi Nishimura, Katsuyoshi Takaoka, Vijay Narasimhan, Xiumin Yan, Hidetaka Shiratori, Sudipto Roy, Hiroshi Hamada   +12 more
doaj   +2 more sources

DynAPs and cytoplasmic assembly of axonemal dyneins. [PDF]

J Cell Sci
ABSTRACT Motile cilia are microtubule-based organelles that generate fluid flow through coordinated beating, a process powered by axonemal dynein motors. Dyneins are pre-assembled in the cytoplasm by a suite of proteins called dynein axonemal assembly factors (DNAAFs).
Wallingford JB, Wallingford JB, Brody SL, Horani A, Lee C.   +4 more
europepmc   +3 more sources

C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia. [PDF]

Am J Hum Genet, 2018
Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disorder characterized by destructive respiratory disease and laterality abnormalities due to randomized left-right body asymmetry.
Fassad MR, Shoemark A, le Borgne P, Koll F, Patel M, Dixon M, Hayward J, Richardson C, Frost E, Jenkins L, Cullup T, Chung EMK, Lemullois M, Aubusson-Fleury A, Hogg C, Mitchell DR, Tassin AM, Mitchison HM.   +17 more
europepmc   +2 more sources

The Motility of Axonemal Dynein Is Regulated by the Tubulin Code [PDF]

Biophysical Journal, 2014
Microtubule diversity, arising from the utilization of different tubulin genes and from posttranslational modifications, regulates many cellular processes including cell division, neuronal differentiation and growth, and centriole assembly.
Howard, Jonathon, Howard, J., Alper, Joshua D., Alper, J., Decker, F., Agana, B., Agana, Bernice, Decker, Franziska   +7 more
core   +5 more sources