Results 41 to 50 of about 1,942 (177)

Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia [PDF]

, 2001
Dyneins are multisubunit protein complexes that couple ATPase activity with conformational changes. They are involved in the cytoplasmatic movement of organelles (cytoplasmic dyneins) and the bending of cilia and flagella (axonemal dyneins), Here we ...
Rossier, C, Jorissen, M., Bartoloni, Lucia, Sainsbury, A, She, J. X., Marron, M. P., Armengot, M., Meeks, M., Sainsbury, A., She, J-X, She, JX, Blouin, JL, Blouin, Jean-Louis, Chung, E., Gardiner, R. M., Delozier-Blanchet, CD, Jorissen, M, Sainsbury, Amanda, Delozier-Blanchet, C. D., Meeks, M, Blouin, J-L, Scott, Hamish Steele, Rossier, Colette, Antonarakis, Stylianos, Maiti, AK, Antonarakis, SE, Gehrig, C, Maiti, A. K., Chung, E, Armengot, M, Gardiner, RM, Marron, MP, Lander, E. S., Bartoloni, L, Lander, ES, Scott, HS, Gehrig, Corinne   +36 more
core   +1 more source

Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.

PLoS Genetics, 2020
Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, reduced fertility, and randomization of the left/right body axis. It is caused by defects of motile cilia and sperm flagella.
Ximena M Bustamante-Marin, Amjad Horani, Mihaela Stoyanova, Wu-Lin Charng, Mathieu Bottier, Patrick R Sears, Wei-Ning Yin, Leigh Anne Daniels, Hailey Bowen, Donald F Conrad, Michael R Knowles, Lawrence E Ostrowski, Maimoona A Zariwala, Susan K Dutcher   +13 more
doaj   +1 more source

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility [PDF]

, 2017
A key player in the intracellular trafficking network is cytoplasmic dynein, a protein complex that transports molecular cargo along microtubule tracks. It has been shown that vertebrate dynein’s movement becomes strikingly enhanced upon interacting with
Gabriel C. Lander, McKenney, Richard J, Richard J. McKenney, Trina A. Schroer, Chowdhury, Saikat, Xu, Yiru, Yiru Xu, Lander, Gabriel C, Saikat Chowdhury, Schroer, Trina A, Danielle A. Grotjahn, Grotjahn, Danielle A   +11 more
core   +1 more source

Emergence of flagellar beating from the collective behavior of individual ATP-powered dyneins [PDF]

, 2016
Flagella are hair-like projections from the surface of eukaryotic cells, and they play an important role in many cellular functions, such as cell-motility.
Onck, P. R., Namdeo, S.
core   +1 more source

The Coordination and Regulation of Axonemal Dynein [PDF]

Biophysical Journal, 2017
Molecular motor proteins drive the motility behind cellular dynamics. Recent advances in structural biology and single-molecule biophysics have led to a detailed understanding of many motor protein mechanisms. However, two understudied areas include the regulation and the coordination of motor proteins, particularly axonemal dyneins, which are the ...
openaire   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Ciliary Motility: Regulation of Axonemal Dynein Motors [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Ciliary motility is crucial for the development and health of many organisms. Motility depends on the coordinated activity of multiple dynein motors arranged in a precise pattern on the outer doublet microtubules. Although significant progress has been made in elucidating the composition and organization of the dyneins, a comprehensive understanding of
Rasagnya, Viswanadha, Winfield S, Sale, Mary E, Porter   +2 more
openaire   +2 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization

Cellular Physiology and Biochemistry, 2018
Background/Aims: Nodal cilia that rotate in the ventral node play an important role in establishing left-right asymmetry during embryogenesis; however, inv mutant cilia present abnormal movement and induce laterality defects.
Yanan Yu, Kyosuke Shinohara, Huanming Xu, Zhenfeng Li, Tomoki Nishida, Hiroshi Hamada, Yuanqing Xu, Jingqi Zhou, Daisy Shao, Xiangchen Li, Duanduan Chen   +10 more
doaj   +1 more source

Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]

Biophysical Journal, 2014
We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail ...
Shimizu, Youské, Sakakibara, Hitoshi, Kojima, Hiroaki, Oiwa, Kazuhiro   +3 more
openaire   +2 more sources