Results 41 to 50 of about 2,176 (124)

Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]

Biophysical Journal, 2014
We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail ...
Shimizu, Youské, Sakakibara, Hitoshi, Kojima, Hiroaki, Oiwa, Kazuhiro   +3 more
openaire   +2 more sources

New Insights Into the Three‐Dimensional Mechanics of the Flagellar Beat Cycle

Cytoskeleton, EarlyView.
ABSTRACT Advances in imaging at the molecular scale have provided greater detail concerning the three‐dimensional structure of the ciliary/flagellar axoneme. Additionally, it has recently been confirmed that electrostatic forces regulate the dynein‐tubulin interaction at the microtubule binding domain (MTBD) of dynein, and at the junction of the nexin ...
Charles B. Lindemann
wiley   +1 more source

The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization

Cellular Physiology and Biochemistry, 2018
Background/Aims: Nodal cilia that rotate in the ventral node play an important role in establishing left-right asymmetry during embryogenesis; however, inv mutant cilia present abnormal movement and induce laterality defects.
Yanan Yu, Kyosuke Shinohara, Huanming Xu, Zhenfeng Li, Tomoki Nishida, Hiroshi Hamada, Yuanqing Xu, Jingqi Zhou, Daisy Shao, Xiangchen Li, Duanduan Chen   +10 more
doaj   +1 more source

Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia [PDF]

, 2001
Dyneins are multisubunit protein complexes that couple ATPase activity with conformational changes. They are involved in the cytoplasmatic movement of organelles (cytoplasmic dyneins) and the bending of cilia and flagella (axonemal dyneins), Here we ...
Rossier, C, Jorissen, M., Bartoloni, Lucia, Sainsbury, A, She, J. X., Marron, M. P., Armengot, M., Meeks, M., Sainsbury, A., She, J-X, She, JX, Blouin, JL, Blouin, Jean-Louis, Chung, E., Gardiner, R. M., Delozier-Blanchet, CD, Jorissen, M, Sainsbury, Amanda, Delozier-Blanchet, C. D., Meeks, M, Blouin, J-L, Scott, Hamish Steele, Rossier, Colette, Antonarakis, Stylianos, Maiti, AK, Antonarakis, SE, Gehrig, C, Maiti, A. K., Chung, E, Armengot, M, Gardiner, RM, Marron, MP, Lander, E. S., Bartoloni, L, Lander, ES, Scott, HS, Gehrig, Corinne   +36 more
core   +1 more source

Seminal Biomarkers and Sperm Proteomic Signatures Differentiate Acute and Chronic Male Accessory Gland Inflammation

Andrology, EarlyView.
ABSTRACT Background Male accessory gland inflammation (MAGI) comprises a heterogeneous group of inflammatory conditions that may differentially affect the seminal microenvironment and sperm function. However, whether transrectal ultrasound (TRUS)‐defined MAGI phenotypes correspond to distinct biological profiles remains insufficiently characterized ...
Emanuela Teveroni, Fiorella Di Nicuolo, Giorgia Mazzuccato, Alessandro Oliva, Emanuele Pierpaolo Vodola, Francesca Mancini, Carla Di Nardo, Edoardo Vergani, Michela Cicchinelli, Federica Iavarone, Cassandra Serantoni, Giuseppe Maulucci, Alessia Riente, Alfredo Pontecorvi, Andrea Urbani, Domenico Milardi, Silvia Baroni   +16 more
wiley   +1 more source

Biallelic Truncating Variant in LRGUK Is Associated With Severe Multiple Morphological Abnormalities of the Sperm Flagella and Sperm Nuclear Defects in Humans

Clinical Genetics, EarlyView.
A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem, Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Célia Tebbakh, Nicolas Thierry‐Mieg, Marie Bidart, Antonella Migliaccio, Rosanna Chianese, Christophe Arnoult, Raoudha Zouari, Zine‐Eddine Kherraf, Pierre F. Ray, Guillaume Martinez, Charles Coutton   +14 more
wiley   +1 more source

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

PLoS Genetics, 2014
Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill   +23 more
doaj   +1 more source

Emergence of flagellar beating from the collective behavior of individual ATP-powered dyneins [PDF]

, 2016
Flagella are hair-like projections from the surface of eukaryotic cells, and they play an important role in many cellular functions, such as cell-motility.
Onck, P. R., Namdeo, S.
core   +2 more sources

Model for Unidirectional Movement of Axonemal and Cytoplasmic Dynein Molecules [PDF]

Acta Biochimica et Biophysica Sinica, 2006
A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide state and the change between strong and weak microtubule-binding is determined naturally by the variation of ...
Xie, Ping, Dou, Shuo-Xing, Wang, Peng-Ye
openaire   +3 more sources

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

Journal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux, Christian Otis, Monique Turmel   +2 more
wiley   +1 more source