Results 61 to 70 of about 2,176 (124)

C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia [PDF]

, 2018
Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disorder characterized by destructive respiratory disease and laterality abnormalities due to randomized left-right body asymmetry.
Aubusson-Fleury, Anne, David R. Mitchell, Aubusson-Fleury, A, Emily Frost, Eddie M.K. Chung, Mitchell, David R., Mellisa Dixon, Anne Aubusson-Fleury, Tassin, Anne-Marie, Tassin, A-M, le Borgne, P, Lucy Jenkins, Chung, EMK, Amelia Shoemark, Frost, E, Jenkins, L, Hannah M. Mitchison, Lemullois, Michel, Hogg, C, Dixon, Mellisa, Fassad, Mahmoud R., Shoemark, Amelia; id_orcid, Borgne, Pierrick, Le, le Borgne, Pierrick, Hayward, Jane, Hogg, Claire, Richardson, Charlotte, Mitali Patel, Jenkins, Lucy, Koll, France, Fassad, MR, Thomas Cullup, Pierrick le Borgne, Charlotte Richardson, Koll, F, Dixon, M, Borgne, Pierrick,, Cullup, Thomas, Patel, Mitali, Mitchison, Hannah M., Hayward, J, Richardson, C, Chung, Eddie M. K., Patel, M, Frost, Emily, Claire Hogg, Lemullois, M, Shoemark, Amelia, Cullup, T, Mitchison, HM, Mitchell, DR, Shoemark, A, Jane Hayward, Michel Lemullois, Mahmoud R. Fassad, France Koll, Anne-Marie Tassin   +56 more
core   +2 more sources

Systematic Reanalysis of Whole‐Exome Sequencing in Genetically Unsolved Pediatric Primary Ciliary Dyskinesia

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Background Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder, and despite advances in next‐generation sequencing, a substantial proportion of clinically suspected pediatric cases remain without a molecular diagnosis.
Tilbe Hakçıl Öz, Tuğba Şişmanlar Eyüboğlu, Ayşe Tana Aslan, Nilgün Kula, Gülsüm Kayhan   +4 more
wiley   +1 more source

Integrated control of axonemal dynein AAA+ motors [PDF]

Journal of Structural Biology, 2012
Axonemal dyneins are AAA(+) enzymes that convert ATP hydrolysis to mechanical work. This leads to the sliding of doublet microtubules with respect to each other and ultimately the generation of ciliary/flagellar beating. However, in order for useful work to be generated, the action of individual dynein motors must be precisely controlled.
openaire   +2 more sources

Identification of the Outer-Inner Dynein Linker as a Hub Controller for Axonemal Dynein Activities [PDF]

Current Biology, 2013
In flagella, the outer dynein arm (ODA) and inner dynein arm (IDA) play distinct roles in generating beating motion. However, functional communications between the two dyneins have not been investigated.Here, we demonstrated by cryo-electron microscopy and chemical crosslinking that intermediate chain 2 (IC2) of ODAs interacts with the dynein ...
Oda, Toshiyuki, Yagi, Toshiki, Yanagisawa, Haruaki, Kikkawa, Masahide   +3 more
openaire   +2 more sources

Genes Related to Sperm Motility Are Under Recent Ongoing Selection in Two Shorebird Species With a Polygynous Mating System and Frequent Multiple Paternity

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT The analysis of the genomic architecture of selection can be insightful for the understanding of sexual conflict and sexual selection acting in wild populations. In general, there will be a wide range of possible targets of selection in the reproductive system of sexually promiscuous species.
Jakob C. Mueller, Bart Kempenaers
wiley   +1 more source

Range‐Wide Genetic Population Structure and Environmental Adaptation in the Eastern Oyster (Crassostrea virginica) Provides Insight for Aquaculture

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT Selective breeding in aquaculture is necessary to establish food security and meet demand for sustainably produced protein. An informed selective breeding program requires understanding how population structure, environmental adaptation, and human activities shape natural genetic variation in wild conspecifics.
Madeline G. Eppley, Kiran Bajaj, Camille Rumberger, Elisabeth Leung, Nicole Mongillo, Jessica Small, Katie E. Lotterhos   +6 more
wiley   +1 more source

Axonemal structures reveal mechanoregulatory and disease mechanisms

, 2023
Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and to enable spermatozoa and unicellular eukaryotes to swim.
S Velkova (13438410), RA Hirst (7697936), T Burgoyne (17463153), A Brown (4108510), MR Fassad (17463144), HM Mitchison (17463156), M Bottier (17463150), C O’Callaghan (11759906), T Walton (7835999), M Gui (17463141), E Haarman (17463147)   +10 more
core   +3 more sources

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, Volume 83, Issue 7, Page 457-465, July 2026.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Molecular Profiling of Extracellular Vesicles Isolated from Boar Reproductive Fluids

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs) are small membrane‐bound structures that facilitate intercellular communication in the reproductive system, modulating gamete maturation, capacitation, immunomodulation and fertilization. Despite pigs’ high relevance as a biomedical model, many aspects of EV biology remain poorly understood.
Veronika Kraus, Barbora Doleckova, Michaela Frolikova, Ondrej Sanovec, Daniela Spevakova, Zuzana Pilsova, Aneta Pilsova, Katerina Komrskova, Ondrej Simonik, Pavla Postlerova   +9 more
wiley   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, Volume 14, Issue 5, Page 1240-1248, July 2026.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source