Results 51 to 60 of about 1,942 (177)

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Clockwise Translocation of Microtubules by Flagellar Inner-Arm Dyneins In Vitro

, 2008
Cilia and flagella are equipped with multiple species of dyneins that have diverse motor properties. To assess the properties of various axonemal dyneins of Chlamydomonas, in vitro microtubule translocation by isolated dyneins was examined with and ...
Ritsu Kamiya, Kikushima, Kenji, Kenji Kikushima, Kamiya, Ritsu   +3 more
core   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, Volume 14, Issue 5, Page 1240-1248, July 2026.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

PLoS Genetics, 2014
Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill   +23 more
doaj   +1 more source

Model for Unidirectional Movement of Axonemal and Cytoplasmic Dynein Molecules [PDF]

Acta Biochimica et Biophysica Sinica, 2006
A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide state and the change between strong and weak microtubule-binding is determined naturally by the variation of ...
Xie, Ping, Dou, Shuo-Xing, Wang, Peng-Ye
openaire   +3 more sources

Wave Mechanics of Ciliary Proteins: Quantum‐Enabled Sensing and Energy Transfer in the “Cellular Antenna”

Aggregate, Volume 7, Issue 6, June 2026.
This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian, Dylan Davidoff, Justin R. Caram, Thomas P. Fay, Aarat P. Kalra, Paul S. Weiss   +5 more
wiley   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment

, 1997
Dynein heavy chains (DHCs) are the main components of multisubunit motor ATPase complexes called dyneins. Axonemal dyneins provide the driving force for ciliary and flagellar motility.
Serge Amselem, Duriez, Bénédicte, Fabrice Magnino, Bénédicte Duriez, Goossens, Michel, Escudier, Estelle, Michel Goossens, Chapelin, Catherine, Estelle Escudier, Magnino, Fabrice, Amselem, Serge, Catherine Chapelin   +11 more
core   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, Volume 13, Issue 30, 28 May 2026.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source