Results 51 to 60 of about 3,025 (188)

Forkhead Transcription Factor Fd3F Cooperates with Rfx to Regulate a Gene Expression Program for Mechanosensory Cilia Specialization [PDF]

, 2012
Cilia have evolved hugely diverse structures and functions to participate in a wide variety of developmental and physiological processes. Ciliary specialization requires differences in gene expression, but few transcription factors are known to regulate ...
Göpfert, Martin C, Jarman, Andrew P, Karak, Somdatta, Moore, Daniel J, Newton, Fay G, zur Lage, Petra I   +5 more
core   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Computer Simulation of Flagellar Movement X. Doublet pair splitting and bend propagation modeled using stochastic dynein kinetics [PDF]

, 2014
Experimental observations on cyclic splitting and bending by a flagellar doublet pair are modeled using forces obtained from a model for dynein mechanochemistry, based on ideas introduced by Andrew Huxley and Terrill Hill and extended previously for ...
Brokaw, Charles J.
core   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

The Diagnosis of Primary Ciliary Dyskinesia: Putting The European Respiratory/American Thoracic Guideline Into Practice

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare inherited disease which is characterised by progressive lung disease, chronic rhinosinusitis, repeated middle ear infections, laterality defects, and reduced fertility. An early diagnosis is critical to reduce morbidity, however diagnosis is often delayed due to the heterogeneity in clinical ...
Katharine Harman, Amjad Horani, Amelia Shoemark   +2 more
wiley   +1 more source

Integrated control of axonemal dynein AAA+ motors [PDF]

Journal of Structural Biology, 2012
Axonemal dyneins are AAA(+) enzymes that convert ATP hydrolysis to mechanical work. This leads to the sliding of doublet microtubules with respect to each other and ultimately the generation of ciliary/flagellar beating. However, in order for useful work to be generated, the action of individual dynein motors must be precisely controlled.
openaire   +2 more sources

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, Volume 33, Issue 2, Page 505-516, April 2026.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source

Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules [PDF]

, 2015
Cytoplasmic dynein is a dimeric AAA+ motor protein that performs critical roles in eukaryotic cells by moving along microtubules using ATP. Here using cryo-electron microscopy we directly observe the structure of Dictyostelium discoideum dynein dimers on
A Gennerich, A Hyman, A Yildiz, AA Hyman, AF Neuwald, AJ Roberts, AJ Roberts, AJ Roberts, AP Carter, C Veigel, CV Sindelar, D Chrétien, D Chrétien, DJ-K Hu, EF Pettersen, FB Cleary, G Mocz, H Schmidt, H Schmidt, H Sui, H Ueno, J Eschbach, J Frank, J Lin, J Lipka, JA Mindell, JR Kardon, K Furuta, K Imamula, KMR Bhat, KS Thorn, L-L Frado, LA Amos, M Fu, MA DeWitt, MA Schlager, ML Walker, MP Nicholas, N Billington, N Hirokawa, N Numata, P Meurer-Grob, RB Vallee, RB Vallee, RD Vale, RD Vale, RJ McKenney, S Chowdhury, S Toba, SA Burgess, SA Burgess, SJ Ludtke, SL Reck-Peterson, T Kon, T Kon, T Kon, T Kon, T Movassagh, T Shima, T Shima, T Torisawa, V Belyy, W Kabsch, WB Redwine, WH Qiu, Y Nishikawa   +65 more
core   +1 more source

Sperm defects in primary ciliary dyskinesia and related causes of male infertility [PDF]

, 2020
The core axoneme structure of both the motile cilium and sperm tail has the same ultrastructural 9 + 2 microtubular arrangement. Thus, it can be expected that genetic defects in motile cilia also have an effect on sperm tail formation.
Loebinger, Michael R., Mitchison, Hannah M., Patel, Mitali, Shoemark, Amelia, Sironen, Anu   +4 more
core   +2 more sources