Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. [PDF]
PLoS Pathogens, 2006 The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum ...
Katherine S Ralston, Kent L Hill
doaj +1 more source
Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella [PDF]
, 2015 Axonemal dyneins are the molecular motors responsible for the beating of cilia and flagella. These motors generate sliding forces between adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure inside the flagellum.
Geyer, Veikko +4 more
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Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms [PDF]
, 2017 Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated.
Alford Lea M. +13 more
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Torque Generation by Axonemal Outer-Arm Dynein [PDF]
Biophysical Journal, 2015 Outer-arm dynein is the main engine providing the motive force in cilia. Using three-dimensional tracking microscopy, we found that contrary to previous reports Tetrahymena ciliary three-headed outer-arm dynein (αβγ) as well as proteolytically generated two-headed (βγ) and one-headed (α) subparticles showed clockwise rotation of each sliding ...
Yamaguchi, Shin +5 more
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Ciliary Motility: Regulation of Axonemal Dynein Motors [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 Ciliary motility is crucial for the development and health of many organisms. Motility depends on the coordinated activity of multiple dynein motors arranged in a precise pattern on the outer doublet microtubules. Although significant progress has been made in elucidating the composition and organization of the dyneins, a comprehensive understanding of
Rasagnya, Viswanadha +2 more
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Effects of antibodies against dynein and tubulin on the stiffness of flagellar axonemes [PDF]
, 1981 Antidynein antibodies, previously shown to inhibit flagellar oscillation and active sliding of axonemal microtubules, increase the bending resistance of axonemes measured under relaxing conditions, but not the bending resistance of axonemes measured ...
Asai, D. J. +3 more
core +1 more source
ZMYND10 functions in a chaperone relay during axonemal dynein assembly [PDF]
, 2018 Molecular chaperones promote the folding and macromolecular assembly of a diverse set of ‘client’ proteins. How ubiquitous chaperone machineries direct their activities towards specific sets of substrates is unclear.
Dodd Daniel O +17 more
core +8 more sources
Inner lumen proteins stabilize doublet microtubules in cilia and flagella
Nature Communications, 2019 Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown.
Mikito Owa +8 more
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Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]
Biophysical Journal, 2014 We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail ...
Shimizu, Youské +3 more
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X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3 [PDF]
, 2016 By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid.
Al-Turki, Saeed +82 more
core +9 more sources