Results 11 to 20 of about 1,942 (177)

Axonemal Dyneins

, 2009
Stephen M KING, Ritsu Kamiya
exaly   +3 more sources

N-Terminal Processing and Modification of Ciliary Dyneins

Cells, 2023
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King   +2 more
doaj   +2 more sources

Structure and Function of Dynein’s Non-Catalytic Subunits [PDF]

Cells
Dynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
doaj   +2 more sources

Torque Generation by Axonemal Outer-Arm Dynein [PDF]

Biophysical Journal, 2015
Outer-arm dynein is the main engine providing the motive force in cilia. Using three-dimensional tracking microscopy, we found that contrary to previous reports Tetrahymena ciliary three-headed outer-arm dynein (αβγ) as well as proteolytically generated ...
Toyoshima, Yoko Y, Saito, Kei, Yamaguchi, Shin, Nishizaka, Takayuki, Yajima, Junichiro, Sutoh, Miki   +5 more
core   +3 more sources

Comparative structural study on axonemal and cytoplasmic dyneins

Cytoskeleton
AbstractAxonemal dyneins are the driving force of motile cilia, while cytoplasmic dyneins play an essential role in minus‐end oriented intracellular transport. Their molecular structure is indispensable for an understanding of the molecular mechanism of ciliary beating and cargo transport.
Noémi Zimmermann, Takashi Ishikawa
exaly   +4 more sources

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. [PDF]

Nature, 2008
Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia.
Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H.   +22 more
europepmc   +2 more sources

Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins. [PDF]

Mol Biol Cell
Tubulins undergo several kinds of posttranslational modifications (PTMs) including glutamylation and glycylation. The contribution of these PTMs to the motilities of cilia and flagella is still unclear.
Kubo T, Sasaki R, Oda T.
europepmc   +2 more sources

Physical and functional interaction of the ciliopathy proteins Lrrc56 and Odad3 control deployment of axonemal dyneins in vertebrate multiciliated cells [PDF]

Disease Models & Mechanisms
Nayeli G. Reyes-Nava, Chanjae Lee, Ophelia Papoulas, Juyeon Hong, Edward M. Marcotte, John B. Wallingford   +5 more
doaj   +2 more sources

Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein

Scientific Reports, 2022
Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi, Masahiko Yamagishi, Junichiro Yajima   +2 more
doaj   +1 more source

Axonemal structures reveal mechanoregulatory and disease mechanisms [PDF]

, 2023
Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and to enable spermatozoa and unicellular eukaryotes to swim.
Hirst, Robert A., Brown, Alan, Gui, Miao, Fassad, Mahmoud R., Haarman, Eric, Burgoyne, Thomas, O’Callaghan, Christopher, Walton, Travis, Velkova, Simona, Bottier, Mathieu, Mitchison, Hannah M.   +10 more
core   +4 more sources