Results 11 to 20 of about 3,025 (188)

A liquid-like organelle at the root of motile ciliopathy [PDF]

eLife, 2018
Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus.
Ryan L Huizar, Chanjae Lee, Alexander A Boulgakov, Amjad Horani, Fan Tu, Edward M Marcotte, Steven L Brody, John B Wallingford   +7 more
doaj   +3 more sources

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. [PDF]

PLoS Genetics, 2014
Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill   +23 more
doaj   +10 more sources

Comparative structural study on axonemal and cytoplasmic dyneins

Cytoskeleton
AbstractAxonemal dyneins are the driving force of motile cilia, while cytoplasmic dyneins play an essential role in minus‐end oriented intracellular transport. Their molecular structure is indispensable for an understanding of the molecular mechanism of ciliary beating and cargo transport.
Noemi Zimmermann, Takashi Ishikawa
openaire   +5 more sources

Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. [PDF]

Sci Rep, 2015
Karak S, Jacobs JS, Kittelmann M, Spalthoff C, Katana R, Sivan-Loukianova E, Schon MA, Kernan MJ, Eberl DF, Göpfert MC.   +9 more
europepmc   +2 more sources

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. [PDF]

Nature, 2008
Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H.   +22 more
europepmc   +2 more sources

Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]

PLoS ONE, 2012
Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes, Katherine S Ralston, Kent L Hill, Z Hong Zhou   +3 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

Nonlinear amplitude dynamics in flagellar beating [PDF]

Royal Society Open Science, 2017
The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets ...
David Oriola, Hermes Gadêlha, Jaume Casademunt   +2 more
doaj   +1 more source

Identification of new genes involved in human adipogenesis and fat storage. [PDF]

PLoS ONE, 2012
Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes
Jörn Söhle, Nikolaus Machuy, Elma Smailbegovic, Ursula Holtzmann, Elke Grönniger, Horst Wenck, Franz Stäb, Marc Winnefeld   +7 more
doaj   +1 more source

Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

eLife, 2022
In most eukaryotic organisms, cilia and flagella perform a variety of life-sustaining roles related to environmental sensing and motility. Cryo-electron microscopy has provided considerable insight into the morphology and function of flagellar structures,
Justine M Pinskey, Adhya Lagisetty, Long Gui, Nhan Phan, Evan Reetz, Amirrasoul Tavakoli, Gang Fu, Daniela Nicastro   +7 more
doaj   +1 more source