Results 11 to 20 of about 2,176 (124)

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins [PDF]

eLife, 2020
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee, Rachael M Cox, Ophelia Papoulas, Amjad Horani, Kevin Drew, Caitlin C Devitt, Steven L Brody, Edward M Marcotte, John B Wallingford   +8 more
doaj   +2 more sources

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

eLife, 2018
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda   +3 more
doaj   +2 more sources

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS Genetics, 2020
Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide, Wang Kyaw Twan, Hao Lu, Yayoi Ikawa, Lin-Xenia Lim, Nicole Henninger, Hiromi Nishimura, Katsuyoshi Takaoka, Vijay Narasimhan, Xiumin Yan, Hidetaka Shiratori, Sudipto Roy, Hiroshi Hamada   +12 more
doaj   +2 more sources

Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes. [PDF]

, 2006
Productive beating of eukaryotic flagella and cilia requires a strict regulation of axonemal dynein activation. Fundamental to any description of axonemal beating is an understanding of the significance of the central pair microtubules and the degree to ...
Wickstead, B., McKean, P. G., Gull, K., Gadelha, C.   +3 more
core   +5 more sources

Consensus nomenclature for dyneins and associated assembly factors. [PDF]

, 2022
Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility ...
Omran, Heymut, Pazour, Gregory J., Witman, George B., Pfister, K. Kevin, Bruford, Elspeth A., Braschi, Bryony, King, Stephen M.   +6 more
core   +4 more sources

Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein

Scientific Reports, 2022
Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi, Masahiko Yamagishi, Junichiro Yajima   +2 more
doaj   +1 more source

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

eLife, 2022
Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef, Hisashi Tadakuma, Kangmin Yan, Takashi Fujiwara, Kodai Fukumoto, Yuichi Kondo, Hiroko Takazaki, Rofia Boudria, Takuo Yasunaga, Hideo Higuchi, Keiko Hirose   +10 more
doaj   +1 more source

Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]

PLoS ONE, 2012
Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes, Katherine S Ralston, Kent L Hill, Z Hong Zhou   +3 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

N-Terminal Processing and Modification of Ciliary Dyneins

Cells, 2023
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King   +2 more
doaj   +1 more source