Results 21 to 30 of about 1,942 (177)
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]
PLoS ONE, 2012 Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes +3 more
doaj +1 more source
Biophysics and Physicobiology, 2023 Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi +3 more
doaj +1 more source
Consensus nomenclature for dyneins and associated assembly factors.
, 2022 Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility ...
Omran, Heymut +6 more
core +3 more sources
Cytoplasmic factories for axonemal dynein assembly [PDF]
Journal of Cell Science, 2021 ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required for the dynein assembly process, and, in mammals, defects lead
openaire +2 more sources
Nonlinear amplitude dynamics in flagellar beating [PDF]
Royal Society Open Science, 2017 The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets ...
David Oriola +2 more
doaj +1 more source
Identification of new genes involved in human adipogenesis and fat storage. [PDF]
PLoS ONE, 2012 Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes
Jörn Söhle +7 more
doaj +1 more source
eLife, 2022 In most eukaryotic organisms, cilia and flagella perform a variety of life-sustaining roles related to environmental sensing and motility. Cryo-electron microscopy has provided considerable insight into the morphology and function of flagellar structures,
Justine M Pinskey +7 more
doaj +1 more source
PLoS Genetics, 2021 Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan +5 more
doaj +1 more source
Space-dependent formation of central pair microtubules and their interactions with radial spokes. [PDF]
PLoS ONE, 2014 Cilia and flagella contain nine outer doublet microtubules and a pair of central microtubules. The central pair of microtubules (CP) is important for cilia/flagella beating, as clearly shown by primary ciliary dyskinesia resulting from the loss of the CP.
Yuki Nakazawa +4 more
doaj +1 more source