Results 71 to 80 of about 3,025 (188)

Axonemal dynein assembly requires the R2TP complex component Pontin [PDF]

Development, 2017
Pontin (Ruvbl1) and Reptin (Ruvbl2) are closely related AAA ATPases. They are components of the Ruvbl1-Ruvbl2-Tah1-Pih1 (R2TP) complexes that function as co-chaperones for the assembly of multiple macromolecular protein complexes. Here, we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pontin and Reptin function ...
Yuanyuan Li, Lu Zhao, Shiaulou Yuan, Jiefang Zhang, Zhaoxia Sun   +4 more
openaire   +2 more sources

DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport [PDF]

, 2017
DNAAF1 (LRRC50) is a cytoplasmic protein required for dynein heavy chain assembly and cilia motility, and DNAAF1 mutations cause primary ciliary dyskinesia (PCD; MIM 613193).
Adzhubei, Amelia Shoemark, Anil Shenoy, Basten, Beryl Adler, Brueckner, Chiara Bacchelli, Christopher M Watson, Claire Hogg, Colin A Johnson, Conrad, Dina Abdelmottaleb, Dominic Norris, Duquesnoy, Eamonn Sheridan, Eduardo Moya, Emma Parkes, Fliegauf, Fowkes, Francis, Freshour, Glenn van de Hoek, Gonzalez-Perez, Grigoletto, Hannah M Mitchison, Hirokawa, Hom, Ian R Berry, Inaba, Kakihara, Karsten Boldt, Katarzyna Szymanska, Kennedy, Kent, Kircher, Kumar, Leigh, Li, Li, Li, Lin, Litchfield, Loges, Loreng, Louise Hattingh, Lucas, Marius Ueffing, McKenna, McLaren, Miao, Mitali P Patel, Moller, Nakamura, Nakhleh, Nicastro, Nine V Knoers, Olcese, Omran, Paul J Winyard, Pazour, Peeters, Peter J Scambler, Rachel H Giles, Robert Yates, Ronald Roepman, Rosen, Rosenbaum, Rosie Little, Rottbauer, Seo, Shinohara, Shoemark, Sullivan-Brown, Sun, Sutherland, Swisher, Taipale, Thorvaldsdottir, Van der Auwera, van Rooijen, Verity L Hartill, Wallmeier, Ware, Watson, Williams, Yamamoto, Zariwala, Zhao   +87 more
core   +6 more sources

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

International Journal of Cancer, Volume 158, Issue 1, Page 120-130, 1 January 2026.
What's new? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R. Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki   +16 more
wiley   +1 more source

The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose Mammalian sperm require a large amount of ATP to sustain motility. While glycolysis and oxidative phosphorylation (OXPHOS) are established ATP sources, they cannot fully explain motility maintenance under glucose‐deprived conditions.
Kosei Oishi, Reiji Tokito, Yasushi Yumura, Manabu Yoshida, Kaoru Yoshida, Masatsugu Asada, Koyuki Mikami, Hiroyuki Watanabe, Yuki Muranishi, Yasuyuki Kurihara   +9 more
wiley   +1 more source

Activation of Ciona sperm motility: phosphorylation of dynein polypeptides and effects of a tyrosine kinase inhibitor [PDF]

, 1991
A high molecular mass dynein ATPase polypeptide and a 18–20 kDa dynein light chain of Ciona sperm flagella are phosphorylated during in vivo activation of motility or in vitro activation of motility by incubation with cyclic AMP.
Brokaw, Charles J., Dey, Chinmoy S.
core  

A Flagellar A-Kinase Anchoring Protein with Two Amphipathic Helices Forms a Structural Scaffold in the Radial Spoke Complex [PDF]

, 2012
A-kinase anchoring proteins (AKAPs) contain an amphipathic helix (AH) that binds the dimerization and docking (D/D) domain, RIIa, in cAMP-dependent protein kinase A (PKA). Many AKAPs were discovered solely based on the AH–RIIa interaction in vitro.
Alto, Angelo, Banky, Barber, Brokaw, Burns-Hamuro, Cao, Carr, Carr, Carr, Chen, Cho, Diener, Diener, Fujita, Gaillard, Gaillard, Gold, Greengard, Gupta, Habermacher, Habermacher, Herberg, Hirsch, Howard, Hsu, Huang, Jarnaess, Jennifer M. Dienes, Jiang, Kammerer, Kinderman, Kindle, Klauck, Kohno, Li, Martin St. Maurice, Mastronarde, Mauban, Means, Mitchell, Morikis, Newell, Nicastro, Omoto, Patel, Patel-King, Pauling, Pigino, Pinfen Yang, Priyanka Sivadas, Roguev, Rual, Sarma, Satir, Scott, Silflow, South, Wang, Warner, Wei, Welch, William D. Meek, Williams, Wirschell, Witman, Xia, Xu, Yang, Yang, Yang, Yang   +71 more
core   +2 more sources

Exploratory Multiomics Profiling Reveals ACTN4‐Centric Cytoskeletal Failure and Environmental Arsenic Association in Morphologically Defined Oligoasthenoteratospermia Subtypes

Andrologia, Volume 2026, Issue 1, 2026.
Background Oligoasthenoteratospermia (OAT) represents a major cause of male infertility. The molecular mechanisms underlying sperm morphological defects, particularly their potential interplay with environmental exposure‐associated molecular alterations, remain poorly understood and warrant exploratory investigation.
Shuting Cheng, Xin Zhuo, Jinzhan Yao, Mengyue Feng, Yuan Yu, Xiaohui Jiang, Xin Liang, Xudong Shan, Zhou Jiang, Harleen Khatra   +9 more
wiley   +1 more source

Identification of a Novel DNAAF3 Variant in a 54‐Year‐Old Patient With Newly Diagnosed Primary Ciliary Dyskinesia (PCD)

Case Reports in Genetics, Volume 2026, Issue 1, 2026.
Primary ciliary dyskinesia (PCD) is a rare and heterogeneous inherited disease characterized by impaired mucociliary clearance. Patients with PCD typically present with recurrent respiratory infections resulting in the development of bronchiectasis. Even though awareness of the disease has increased over the years, PCD remains underdiagnosed.
Mirja M. Wirtz, Sabine Ebner, Anna Pleyers, Natalie Firlei-Fleischmann, Richard Untersteiner, Michael Studnicka, Irfan Ahmad   +6 more
wiley   +1 more source

Cytoskeleton and Cell Motility [PDF]

, 2009
The present article is an invited contribution to the Encyclopedia of Complexity and System Science, Robert A. Meyers Ed., Springer New York (2009). It is a review of the biophysical mechanisms that underly cell motility.
Risler, Thomas
core   +3 more sources

A microtubule-dynein tethering complex regulates the axonemal inner dyneinf(I1)

Molecular Biology of the Cell, 2018
Motility of cilia/flagella is generated by a coordinated activity of thousands of dyneins. Inner dynein arms (IDAs) are particularly important for the formation of ciliary/flagellar waveforms, but the molecular mechanism of IDA regulation is poorly understood. Here we show using cryoelectron tomography and biochemical analyses of Chlamydomonas flagella
Kubo, Tomohiro, Hou, Yuqing, Cochran, Deborah A., Witman, George B., Oda, Toshiyuki   +4 more
openaire   +3 more sources