Results 11 to 20 of about 8,740 (224)

Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor. [PDF]

Cytoskeleton (Hoboken)
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King SM.
europepmc   +2 more sources

The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division

Frontiers in Cell and Developmental Biology, 2020
Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa, Takayuki Torisawa, Akatsuki Kimura, Akatsuki Kimura   +3 more
doaj   +1 more source

Dynein-Inspired Multilane Exclusion Process with Open Boundary Conditions

Entropy, 2021
Motivated by the sidewise motions of dynein motors shown in experiments, we use a variant of the exclusion process to model the multistep dynamics of dyneins on a cylinder with open ends.
Riya Nandi, Uwe C. Täuber, Priyanka
doaj   +1 more source

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

eLife, 2020
Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee, Rachael M Cox, Ophelia Papoulas, Amjad Horani, Kevin Drew, Caitlin C Devitt, Steven L Brody, Edward M Marcotte, John B Wallingford   +8 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

Novel DNAH1 Mutation Loci Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Literature Review

The World Journal of Men's Health, 2022
The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella.
Bao-Jun Zhuang, Su-Yun Xu, Liang Dong, Pei-Hai Zhang, Bao-Lin Zhuang, Xiao-Peng Huang, Guang-Sen Li, Yao-Dong You, DiʼAng Chen, Xu-Jun Yu, De-Gui Chang   +10 more
doaj   +1 more source

N-Terminal Processing and Modification of Ciliary Dyneins

Cells, 2023
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King   +2 more
doaj   +1 more source

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

eLife, 2018
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda   +3 more
doaj   +1 more source

Structure of a microtubule-bound axonemal dynein

Nature Communications, 2021
Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
doaj   +1 more source

The Versatile Molecular Complex Component LC8 Promotes Several Distinct Steps of Flagellar Assembly [PDF]

, 2012
LC8 is present in various molecular complexes. However, its role in these complexes remains unclear. We discovered that although LC8 is a subunit of the radial spoke (RS) complex in Chlamydomonas flagella, it was undetectable in the RS precursor that is ...
Anjali Gupta, Barbar, Bergen, Bloch, Dennis R. Diener, DiBella, Diener, Diener, Dymek, Dymek, Espindola, Fejtova, Gaillard, Hall, Harris, Heuser, Huang, Jaffrey, Jivan, Joel L. Rosenbaum, Johnson, Kamiya, Kindle, King, LeDizet, Liang, Lightcap, Lin, Lo, Lo, Luo, Naisbitt, Navarro-Lérida, Nicastro, Patel-King, Pazour, Pazour, Pfister, Pigino, Pinfen Yang, Piperno, Piperno, Porter, Priyanka Sivadas, Puthalakath, Qin, Rodríguez-Crespo, Rompolas, Sakato, Segal, Stelter, Summers, Tan, Warner, Wei, Williams, Wirschell, Yang, Yang, Yang, Yang, Yang   +61 more
core   +2 more sources