Results 11 to 20 of about 824 (196)
Current Biology, 2023 Dyneins are a family of motor proteins that carry out motility and force generation functions towards the minus end of microtubule filaments. Cytoplasmic dynein (dynein-1) is responsible for transporting intracellular cargos in the retrograde direction in the cytoplasm, anchoring several organelles to the microtubule network, driving nuclear migration ...
Ahmet, Yildiz, Yuanchang, Zhao
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N-Terminal Processing and Modification of Ciliary Dyneins
Cells, 2023 Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku +2 more
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eLife, 2018 Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi +3 more
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Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
eLife, 2018 We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski +7 more
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, 2016 Dyneins are a class of microtubule (MT)-based, cytoskeletal motors that are found in two forms: cytoplasmic and axonemal. Dyneins transport cellular cargoes toward the MT minus-end by converting chemical energy in the form of adenosine triphosphate (ATP) to mechanical work.
Cypranowska, C.A. +2 more
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Dynein and dynein-related genes [PDF]
Cell Motility and the Cytoskeleton, 1998 Dyneins are large, multisubunit ATPases that interact with microtubules to generate force. Dyneins move eukaryotic cilia and flagella and are in the cytoplasm, where they are involved in the transport of particles and organelles along microtubules and in the transport of condensed chromosomes during mitosis [reviewed in Holzbaur et al., 1994; Gibbons ...
openaire +3 more sources
Structure of a microtubule-bound axonemal dynein
Nature Communications, 2021 Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
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eLife, 2017 Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Jonathan B Steinman +21 more
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PLoS Genetics, 2020 Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide +12 more
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