Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
doaj +1 more source
Force and Motion Generation of Molecular Motors: A Generic Description [PDF]
, 1999 We review the properties of biological motor proteins which move along linear filaments that are polar and periodic. The physics of the operation of such motors can be described by simple stochastic models which are coupled to a chemical reaction.
A. Ajdari +54 more
core +3 more sources
Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella [PDF]
, 2015 Axonemal dyneins are the molecular motors responsible for the beating of cilia and flagella. These motors generate sliding forces between adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure inside the flagellum.
Geyer, Veikko +4 more
core +2 more sources
PLoS Genetics, 2021 Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan +5 more
doaj +1 more source
Effects of antibodies against dynein and tubulin on the stiffness of flagellar axonemes [PDF]
, 1981 Antidynein antibodies, previously shown to inhibit flagellar oscillation and active sliding of axonemal microtubules, increase the bending resistance of axonemes measured under relaxing conditions, but not the bending resistance of axonemes measured ...
Asai, D. J. +3 more
core +1 more source
From aggressive driving to molecular motor traffic [PDF]
, 2006 Motivated by recent experimental results for the step sizes of dynein motor proteins, we develope a cellular automata model for intra-cellular traffic of dynein motors incorporating special features of the hindrance-dependent step size of the individual ...
Chowdhury, Debashish +2 more
core +4 more sources
Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins
Viruses, 2022 Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to
Dahee Seo, Don B. Gammon
doaj +1 more source
Collective effects in intra-cellular molecular motor transport: coordination, cooperation and competetion [PDF]
, 2006 Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells.
Chowdhury, Debashish
core +2 more sources
Genetic analysis of the cytoplasmic dynein subunit families.
PLoS Genetics, 2006 Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister +7 more
doaj +2 more sources
Ciliobrevins as Tools for Studying Dynein Motor Function
Frontiers in Cellular Neuroscience, 2015 Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien +2 more
doaj +1 more source