Results 41 to 50 of about 5,717 (230)
Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
doaj +1 more source
Axonemal dyneins and force generation by neurons in Drosophila melanogaster ear [PDF]
, 2013 Analogous to vertebrate hair cells, the mechanosensory cilia of Drosophila auditory neurons are motile and serve dual, transducing and actuating roles.
Karak, Somdatta
core +1 more source
, 2012 (A) Dynein network: The green coloring indicates 4 out of 5 hits regarding axonemal dyneins. DNAH7 (also identified in our screen) was not part of the network. Blue symbols represent dyneins which were part of the library but were not determined as hits.
Ursula Holtzmann (180882) +7 more
core +1 more source
PLoS Genetics, 2021 Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan +5 more
doaj +1 more source
Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions [PDF]
Journal of Biological Chemistry, 2010 A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice.
Deng, Wenhan +7 more
openaire +2 more sources
PLoS Genetics, 2017 Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated.
Ryosuke Yamamoto +12 more
doaj +1 more source
Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins
Viruses, 2022 Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to
Dahee Seo, Don B. Gammon
doaj +1 more source
Genetic analysis of the cytoplasmic dynein subunit families.
PLoS Genetics, 2006 Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister +7 more
doaj +2 more sources
Ciliobrevins as Tools for Studying Dynein Motor Function
Frontiers in Cellular Neuroscience, 2015 Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien +2 more
doaj +1 more source