Results 21 to 30 of about 5,717 (230)

Dynein-Inspired Multilane Exclusion Process with Open Boundary Conditions

Entropy, 2021
Motivated by the sidewise motions of dynein motors shown in experiments, we use a variant of the exclusion process to model the multistep dynamics of dyneins on a cylinder with open ends.
Riya Nandi, Uwe C. Täuber, Priyanka
doaj   +1 more source

Dyneins

, 2016
C.A. Cypranowska, A. Yildiz, T. Ishikawa
core   +2 more sources

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

Novel DNAH1 Mutation Loci Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Literature Review

The World Journal of Men's Health, 2022
The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella.
Bao-Jun Zhuang, Su-Yun Xu, Liang Dong, Pei-Hai Zhang, Bao-Lin Zhuang, Xiao-Peng Huang, Guang-Sen Li, Yao-Dong You, DiʼAng Chen, Xu-Jun Yu, De-Gui Chang   +10 more
doaj   +1 more source

Structure of a microtubule-bound axonemal dynein

Nature Communications, 2021
Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
doaj   +1 more source

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS Genetics, 2020
Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide, Wang Kyaw Twan, Hao Lu, Yayoi Ikawa, Lin-Xenia Lim, Nicole Henninger, Hiromi Nishimura, Katsuyoshi Takaoka, Vijay Narasimhan, Xiumin Yan, Hidetaka Shiratori, Sudipto Roy, Hiroshi Hamada   +12 more
doaj   +1 more source

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

eLife, 2017
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Jonathan B Steinman, Cristina C Santarossa, Rand M Miller, Lola S Yu, Anna S Serpinskaya, Hideki Furukawa, Sachie Morimoto, Yuta Tanaka, Mitsuyoshi Nishitani, Moriteru Asano, Ruta Zalyte, Alison E Ondrus, Alex G Johnson, Fan Ye, Maxence V Nachury, Yoshiyuki Fukase, Kazuyoshi Aso, Michael A Foley, Vladimir I Gelfand, James K Chen, Andrew P Carter, Tarun M Kapoor   +21 more
doaj   +1 more source

Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]

PLoS ONE, 2012
Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes, Katherine S Ralston, Kent L Hill, Z Hong Zhou   +3 more
doaj   +1 more source

Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

eLife, 2023
Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in ...
Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa   +2 more
doaj   +1 more source

Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]

PLoS ONE, 2009
BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj   +1 more source