Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]
PLoS ONE, 2012 Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes +3 more
doaj +1 more source
Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates
eLife, 2023 Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in ...
Hiroshi Yamaguchi +2 more
doaj +1 more source
Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins. [PDF]
Mol Biol CellTubulins undergo several kinds of posttranslational modifications (PTMs) including glutamylation and glycylation. The contribution of these PTMs to the motilities of cilia and flagella is still unclear.
Kubo T, Sasaki R, Oda T.
europepmc +3 more sources
Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj +1 more source
Identification of new genes involved in human adipogenesis and fat storage. [PDF]
PLoS ONE, 2012 Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes
Jörn Söhle +7 more
doaj +1 more source
Emergence of flagellar beating from the collective behavior of individual ATP-powered dyneins [PDF]
, 2016 Flagella are hair-like projections from the surface of eukaryotic cells, and they play an important role in many cellular functions, such as cell-motility.
Onck, P. R., Namdeo, S.
core +1 more source
Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
doaj +1 more source
PLoS Genetics, 2020 Ciliary dyneins are preassembled in the cytoplasm before being transported into cilia, and a family of proteins containing the PIH1 domain, PIH proteins, are involved in the assembly process.
Ryosuke Yamamoto +7 more
doaj +1 more source
Structure and Mechanics of Dynein Motors [PDF]
, 2021 Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules. Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells and mediating spindle assembly and chromosome positioning during cell ...
Yildiz, Ahmet +9 more
core +1 more source
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility [PDF]
, 2017 A key player in the intracellular trafficking network is cytoplasmic dynein, a protein complex that transports molecular cargo along microtubule tracks. It has been shown that vertebrate dynein’s movement becomes strikingly enhanced upon interacting with
Gabriel C. Lander +11 more
core +1 more source