Results 31 to 40 of about 5,717 (230)
Dynein light intermediate chains as pivotal determinants of dynein multifunctionality [PDF]
Journal of Cell Science, 2021 ABSTRACT In animal cells, a single cytoplasmic dynein motor mediates microtubule minus-end-directed transport, counterbalancing dozens of plus-end-directed kinesins. The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which engage the ...
Amrita Kumari +3 more
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Identification of new genes involved in human adipogenesis and fat storage. [PDF]
PLoS ONE, 2012 Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes
Jörn Söhle +7 more
doaj +1 more source
Emergence of flagellar beating from the collective behavior of individual ATP-powered dyneins [PDF]
, 2016 Flagella are hair-like projections from the surface of eukaryotic cells, and they play an important role in many cellular functions, such as cell-motility.
Onck, P. R., Namdeo, S.
core +1 more source
Dynein and intraflagellar transport [PDF]
Experimental Cell Research, 2015 Publisher Summary This chapter provides a brief background on intraflagellar transport (IFT) and reviews the studies culminating in the identification of the dynein motor that powers retrograde IFT. IFT is the active movement of multi-subunit particles along axonemal doublet microtubules in the space between the outer-doublet microtubules and the ...
Hou, Yuqing, Witman, George B.
openaire +3 more sources
Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
doaj +1 more source
PLoS Genetics, 2020 Ciliary dyneins are preassembled in the cytoplasm before being transported into cilia, and a family of proteins containing the PIH1 domain, PIH proteins, are involved in the assembly process.
Ryosuke Yamamoto +7 more
doaj +1 more source
Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport [PDF]
, 2015 Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of dyneins on axonal organelles and their collective function during this long ...
Cui, Bianxiao +7 more
core +1 more source
eLife, 2022 Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined.
Xiaoqin Fu +7 more
doaj +1 more source
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility [PDF]
, 2017 A key player in the intracellular trafficking network is cytoplasmic dynein, a protein complex that transports molecular cargo along microtubule tracks. It has been shown that vertebrate dynein’s movement becomes strikingly enhanced upon interacting with
Gabriel C. Lander +11 more
core +1 more source
Inner lumen proteins stabilize doublet microtubules in cilia and flagella
Nature Communications, 2019 Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown.
Mikito Owa +8 more
doaj +1 more source