Results 31 to 40 of about 5,920 (201)
eLife, 2022 Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined.
Xiaoqin Fu +7 more
doaj +1 more source
Inner lumen proteins stabilize doublet microtubules in cilia and flagella
Nature Communications, 2019 Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown.
Mikito Owa +8 more
doaj +1 more source
Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
doaj +1 more source
, 2012 (A) Dynein network: The green coloring indicates 4 out of 5 hits regarding axonemal dyneins. DNAH7 (also identified in our screen) was not part of the network. Blue symbols represent dyneins which were part of the library but were not determined as hits.
Ursula Holtzmann (180882) +7 more
core +1 more source
PLoS Genetics, 2021 Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan +5 more
doaj +1 more source
PLoS Genetics, 2017 Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated.
Ryosuke Yamamoto +12 more
doaj +1 more source
Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport [PDF]
, 2015 Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of dyneins on axonal organelles and their collective function during this long ...
Cui, Bianxiao +7 more
core +1 more source
Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins
Viruses, 2022 Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to
Dahee Seo, Don B. Gammon
doaj +1 more source
Genetic analysis of the cytoplasmic dynein subunit families.
PLoS Genetics, 2006 Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister +7 more
doaj +2 more sources
, 2008 Recent advances in our understanding of the axonemal dyneins reveal them to be much more complex than previously believed. A combination of genetic, molecular genetic, ultrastructural and biochemical approaches is now aiding the elucidation of the ...
Witman, George B.
core +1 more source